An open-label, single-arm pilot study of tocotrienols supplementation on improving memory and attention in healthy young adults
This study aimed to investigate the beneficial effects of tocotrienols (T3) supplementation on one's attention and memory. Eleven healthy subjects were enrolled to receive placebo followed by T3 in 6 weeks. Psychomotor Vigilance Task (PVT) and Digit Span Test (DST) were used to access subjects’...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Online Access: | https://hdl.handle.net/10356/163076 |
| _version_ | 1826117094124552192 |
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| author | Par, Rae Yi Xin Teo, Cheryl Wei Ling Tan, Javier Joon Kiat Ung, Yee Wei Heng, Kiang Soon Hang, Li Ting Yeo, Mervyn Yap, Wei Ney |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Par, Rae Yi Xin Teo, Cheryl Wei Ling Tan, Javier Joon Kiat Ung, Yee Wei Heng, Kiang Soon Hang, Li Ting Yeo, Mervyn Yap, Wei Ney |
| author_sort | Par, Rae Yi Xin |
| collection | NTU |
| description | This study aimed to investigate the beneficial effects of tocotrienols (T3) supplementation on one's attention and memory. Eleven healthy subjects were enrolled to receive placebo followed by T3 in 6 weeks. Psychomotor Vigilance Task (PVT) and Digit Span Test (DST) were used to access subjects’ sustained attention and working memory. Electroencephalogram (EEG) was used to examine the brainwave activity. T3 supplementation significantly improved the memory of the subjects in relative to the baseline as measured by average mean span for forward and reverse DST. Notably, a significant memory enhancement for T3 over placebo was observed. Subjects who consumed T3 have shown faster reaction as compared to placebo as assessed by PVT. T3 supplementation showed an overall reduction in alpha and low-beta power in comparison to placebo, indicating T3 promoted a higher neural efficacy. T3 supplementation may act as a potential nootropic in improving the mental performance and cognitive activity. |
| first_indexed | 2024-10-01T04:22:06Z |
| format | Journal Article |
| id | ntu-10356/163076 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:22:06Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1630762023-02-28T17:11:35Z An open-label, single-arm pilot study of tocotrienols supplementation on improving memory and attention in healthy young adults Par, Rae Yi Xin Teo, Cheryl Wei Ling Tan, Javier Joon Kiat Ung, Yee Wei Heng, Kiang Soon Hang, Li Ting Yeo, Mervyn Yap, Wei Ney School of Biological Sciences Science::Biological sciences Tocotrienols Electroencephalogram This study aimed to investigate the beneficial effects of tocotrienols (T3) supplementation on one's attention and memory. Eleven healthy subjects were enrolled to receive placebo followed by T3 in 6 weeks. Psychomotor Vigilance Task (PVT) and Digit Span Test (DST) were used to access subjects’ sustained attention and working memory. Electroencephalogram (EEG) was used to examine the brainwave activity. T3 supplementation significantly improved the memory of the subjects in relative to the baseline as measured by average mean span for forward and reverse DST. Notably, a significant memory enhancement for T3 over placebo was observed. Subjects who consumed T3 have shown faster reaction as compared to placebo as assessed by PVT. T3 supplementation showed an overall reduction in alpha and low-beta power in comparison to placebo, indicating T3 promoted a higher neural efficacy. T3 supplementation may act as a potential nootropic in improving the mental performance and cognitive activity. Published version This work was supported financially by a research fund from KL-Kepong Oleomas (KLK Oleo) to Davos Life Science Pte Ltd. 2022-11-21T00:59:09Z 2022-11-21T00:59:09Z 2022 Journal Article Par, R. Y. X., Teo, C. W. L., Tan, J. J. K., Ung, Y. W., Heng, K. S., Hang, L. T., Yeo, M. & Yap, W. N. (2022). An open-label, single-arm pilot study of tocotrienols supplementation on improving memory and attention in healthy young adults. Journal of Functional Foods, 92, 105055-. https://dx.doi.org/10.1016/j.jff.2022.105055 1756-4646 https://hdl.handle.net/10356/163076 10.1016/j.jff.2022.105055 2-s2.0-85127301523 92 105055 en Journal of Functional Foods © 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). application/pdf |
| spellingShingle | Science::Biological sciences Tocotrienols Electroencephalogram Par, Rae Yi Xin Teo, Cheryl Wei Ling Tan, Javier Joon Kiat Ung, Yee Wei Heng, Kiang Soon Hang, Li Ting Yeo, Mervyn Yap, Wei Ney An open-label, single-arm pilot study of tocotrienols supplementation on improving memory and attention in healthy young adults |
| title | An open-label, single-arm pilot study of tocotrienols supplementation on improving memory and attention in healthy young adults |
| title_full | An open-label, single-arm pilot study of tocotrienols supplementation on improving memory and attention in healthy young adults |
| title_fullStr | An open-label, single-arm pilot study of tocotrienols supplementation on improving memory and attention in healthy young adults |
| title_full_unstemmed | An open-label, single-arm pilot study of tocotrienols supplementation on improving memory and attention in healthy young adults |
| title_short | An open-label, single-arm pilot study of tocotrienols supplementation on improving memory and attention in healthy young adults |
| title_sort | open label single arm pilot study of tocotrienols supplementation on improving memory and attention in healthy young adults |
| topic | Science::Biological sciences Tocotrienols Electroencephalogram |
| url | https://hdl.handle.net/10356/163076 |
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