Ocular inflammatory events following COVID-19 vaccination: a multinational case series
Background: Inflammatory adverse events following COVID-19 vaccination are being reported amidst the growing concerns regarding vaccine’s immunogenicity and safety, especially in patients with pre-existing inflammatory conditions. Methods: Multinational case series of patients diagnosed with an ocul...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2022
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| Online Access: | https://hdl.handle.net/10356/163086 |
| _version_ | 1811695973677662208 |
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| author | Testi, Ilaria Brandão-de-Resende, Camilo Agrawal, Rupesh Pavesio, Carlos VOIESG |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Testi, Ilaria Brandão-de-Resende, Camilo Agrawal, Rupesh Pavesio, Carlos VOIESG |
| author_sort | Testi, Ilaria |
| collection | NTU |
| description | Background: Inflammatory adverse events following COVID-19 vaccination are being reported amidst the growing concerns regarding vaccine’s immunogenicity and safety, especially in patients with pre-existing inflammatory conditions. Methods: Multinational case series of patients diagnosed with an ocular inflammatory event within 14 days following COVID-19 vaccination collected from 40 centres over a 3 month period in 2021. Results: Seventy patients presented with ocular inflammatory events within 14 days following COVID-19 vaccination. The mean age was 51 years (range, 19–84 years). The most common events were anterior uveitis (n = 41, 58.6%), followed by posterior uveitis (n = 9, 12.9%) and scleritis (n = 7, 10.0%). The mean time to event was 5 days and 6 days (range, 1–14 days) after the first and second dose of vaccine, respectively. Among all patients, 36 (54.1%) had a previous history of ocular inflammatory event. Most patients (n = 48, 68.6%) were managed with topical corticosteroids. Final vision was not affected in 65 (92.9%), whereas 2 (2.9%) and 3 (4.3%) had reduction in visual acuity reduced by ≤3 lines and > 3 lines, respectively. Reported complications included nummular corneal lesions (n = 1, 1.4%), cystoid macular oedema (n = 2, 2.9%) and macular scarring (n = 2, 2.9%). Conclusion: Ocular inflammatory events may occur after COVID-19 vaccination. The findings are based on a temporal association that does not prove causality. Even in the possibility of a causal association, most of the events were mild and had a good visual outcome. |
| first_indexed | 2024-10-01T07:31:59Z |
| format | Journal Article |
| id | ntu-10356/163086 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:31:59Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1630862023-03-05T16:52:06Z Ocular inflammatory events following COVID-19 vaccination: a multinational case series Testi, Ilaria Brandão-de-Resende, Camilo Agrawal, Rupesh Pavesio, Carlos VOIESG Lee Kong Chian School of Medicine (LKCMedicine) Tan Tock Seng Hospital Singapore Eye Research Institute Duke NUS Medical School Science::Medicine Uveitis Ocular Inflammation Background: Inflammatory adverse events following COVID-19 vaccination are being reported amidst the growing concerns regarding vaccine’s immunogenicity and safety, especially in patients with pre-existing inflammatory conditions. Methods: Multinational case series of patients diagnosed with an ocular inflammatory event within 14 days following COVID-19 vaccination collected from 40 centres over a 3 month period in 2021. Results: Seventy patients presented with ocular inflammatory events within 14 days following COVID-19 vaccination. The mean age was 51 years (range, 19–84 years). The most common events were anterior uveitis (n = 41, 58.6%), followed by posterior uveitis (n = 9, 12.9%) and scleritis (n = 7, 10.0%). The mean time to event was 5 days and 6 days (range, 1–14 days) after the first and second dose of vaccine, respectively. Among all patients, 36 (54.1%) had a previous history of ocular inflammatory event. Most patients (n = 48, 68.6%) were managed with topical corticosteroids. Final vision was not affected in 65 (92.9%), whereas 2 (2.9%) and 3 (4.3%) had reduction in visual acuity reduced by ≤3 lines and > 3 lines, respectively. Reported complications included nummular corneal lesions (n = 1, 1.4%), cystoid macular oedema (n = 2, 2.9%) and macular scarring (n = 2, 2.9%). Conclusion: Ocular inflammatory events may occur after COVID-19 vaccination. The findings are based on a temporal association that does not prove causality. Even in the possibility of a causal association, most of the events were mild and had a good visual outcome. Published version 2022-11-21T04:18:07Z 2022-11-21T04:18:07Z 2022 Journal Article Testi, I., Brandão-de-Resende, C., Agrawal, R., Pavesio, C. & VOIESG (2022). Ocular inflammatory events following COVID-19 vaccination: a multinational case series. Journal of Ophthalmic Inflammation and Infection, 12(1), 4-. https://dx.doi.org/10.1186/s12348-021-00275-x 1869-5760 https://hdl.handle.net/10356/163086 10.1186/s12348-021-00275-x 34982290 2-s2.0-85122278156 1 12 4 en Journal of Ophthalmic Inflammation and Infection © The Author(s). 2021 Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. application/pdf |
| spellingShingle | Science::Medicine Uveitis Ocular Inflammation Testi, Ilaria Brandão-de-Resende, Camilo Agrawal, Rupesh Pavesio, Carlos VOIESG Ocular inflammatory events following COVID-19 vaccination: a multinational case series |
| title | Ocular inflammatory events following COVID-19 vaccination: a multinational case series |
| title_full | Ocular inflammatory events following COVID-19 vaccination: a multinational case series |
| title_fullStr | Ocular inflammatory events following COVID-19 vaccination: a multinational case series |
| title_full_unstemmed | Ocular inflammatory events following COVID-19 vaccination: a multinational case series |
| title_short | Ocular inflammatory events following COVID-19 vaccination: a multinational case series |
| title_sort | ocular inflammatory events following covid 19 vaccination a multinational case series |
| topic | Science::Medicine Uveitis Ocular Inflammation |
| url | https://hdl.handle.net/10356/163086 |
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