Structural and mechanistic insights into Mycobacterium abscessus as-partate decarboxylase PanD and a pyrazinoic acid-derived inhibitor

Structural and mechanistic insights into Mycobacterium abscessus as-partate decarboxylase PanD and a pyrazinoic acid-derived inhibitor

Mycobacterium tuberculosis (Mtb) aspartate decarboxylase PanD is required for biosynthesis of the essential cofactor coenzyme A and targeted by the first line drug pyrazinamide (PZA). PZA is a prodrug that is converted by a bacterial amidase into its bioactive form pyrazinoic acid (POA). Employing s...

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Bibliographic Details
Main Authors:	Saw, Wuan Geok, Leow, Chen Yen, Harikishore, Amaravadhi, Shin, Joon, Cole, Malcolm S., Aragaw, Wassihun Wedajo, Ragunathan, Priya, Hegde, Pooja, Aldrich, Courtney C., Dick, Thomas, Grüber, Gerhard
Other Authors:	School of Biological Sciences
Format:	Journal Article
Language:	English
Published:	2022
Subjects:	Science::Biological sciences::Biochemistry Science::Biological sciences::Biophysics Non-Tuberculous Mycobacteria Mycobacterium Abscessus Pyrazinamide Pyrazinoic Acid Coenzyme A Aspartate Decarboxylase
Online Access:	https://hdl.handle.net/10356/163126

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