Honey: an advanced antimicrobial and wound healing biomaterial for tissue engineering applications
Honey was used in traditional medicine to treat wounds until the advent of modern medicine. The rising global antibiotic resistance has forced the development of novel therapies as alternatives to combat infections. Consequently, honey is experiencing a resurgence in evaluation for antimicrobial and...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/163159 |
| _version_ | 1826123001751404544 |
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| author | Mieles, Joel Yupanqui Vyas, Cian Aslan, Enes Humphreys, Gavin Diver, Carl Bartolo, Paulo |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Mieles, Joel Yupanqui Vyas, Cian Aslan, Enes Humphreys, Gavin Diver, Carl Bartolo, Paulo |
| author_sort | Mieles, Joel Yupanqui |
| collection | NTU |
| description | Honey was used in traditional medicine to treat wounds until the advent of modern medicine. The rising global antibiotic resistance has forced the development of novel therapies as alternatives to combat infections. Consequently, honey is experiencing a resurgence in evaluation for antimicrobial and wound healing applications. A range of both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains and biofilms, are inhibited by honey. Furthermore, susceptibility to antibiotics can be restored when used synergistically with honey. Honey's antimicrobial activity also includes antifungal and antiviral properties, and in most varieties of honey, its activity is attributed to the enzymatic generation of hydrogen peroxide, a reactive oxygen species. Non-peroxide factors include low water activity, acidity, phenolic content, defensin-1, and methylglyoxal (Leptospermum honeys). Honey has also been widely explored as a tissue-regenerative agent. It can contribute to all stages of wound healing, and thus has been used in direct application and in dressings. The difficulty of the sustained delivery of honey's active ingredients to the wound site has driven the development of tissue engineering approaches (e.g., electrospinning and hydrogels). This review presents the most in-depth and up-to-date comprehensive overview of honey's antimicrobial and wound healing properties, commercial and medical uses, and its growing experimental use in tissue-engineered scaffolds. |
| first_indexed | 2024-10-01T05:57:29Z |
| format | Journal Article |
| id | ntu-10356/163159 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:57:29Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1631592022-11-26T23:31:29Z Honey: an advanced antimicrobial and wound healing biomaterial for tissue engineering applications Mieles, Joel Yupanqui Vyas, Cian Aslan, Enes Humphreys, Gavin Diver, Carl Bartolo, Paulo School of Mechanical and Aerospace Engineering Singapore Centre for 3D Printing Engineering::Mechanical engineering Honey Antimicrobial Honey was used in traditional medicine to treat wounds until the advent of modern medicine. The rising global antibiotic resistance has forced the development of novel therapies as alternatives to combat infections. Consequently, honey is experiencing a resurgence in evaluation for antimicrobial and wound healing applications. A range of both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains and biofilms, are inhibited by honey. Furthermore, susceptibility to antibiotics can be restored when used synergistically with honey. Honey's antimicrobial activity also includes antifungal and antiviral properties, and in most varieties of honey, its activity is attributed to the enzymatic generation of hydrogen peroxide, a reactive oxygen species. Non-peroxide factors include low water activity, acidity, phenolic content, defensin-1, and methylglyoxal (Leptospermum honeys). Honey has also been widely explored as a tissue-regenerative agent. It can contribute to all stages of wound healing, and thus has been used in direct application and in dressings. The difficulty of the sustained delivery of honey's active ingredients to the wound site has driven the development of tissue engineering approaches (e.g., electrospinning and hydrogels). This review presents the most in-depth and up-to-date comprehensive overview of honey's antimicrobial and wound healing properties, commercial and medical uses, and its growing experimental use in tissue-engineered scaffolds. Published version This research was funded by the Turkish Ministry of National Education, an Engineering and Physical Sciences Research Council (UK) Doctoral Prize Fellowship (EP/R513131/1), and Matoke Holdings. 2022-11-25T06:24:58Z 2022-11-25T06:24:58Z 2022 Journal Article Mieles, J. Y., Vyas, C., Aslan, E., Humphreys, G., Diver, C. & Bartolo, P. (2022). Honey: an advanced antimicrobial and wound healing biomaterial for tissue engineering applications. Pharmaceutics, 14(8), 14081663-. https://dx.doi.org/10.3390/pharmaceutics14081663 1999-4923 https://hdl.handle.net/10356/163159 10.3390/pharmaceutics14081663 36015289 2-s2.0-85137391584 8 14 14081663 en Pharmaceutics © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). application/pdf |
| spellingShingle | Engineering::Mechanical engineering Honey Antimicrobial Mieles, Joel Yupanqui Vyas, Cian Aslan, Enes Humphreys, Gavin Diver, Carl Bartolo, Paulo Honey: an advanced antimicrobial and wound healing biomaterial for tissue engineering applications |
| title | Honey: an advanced antimicrobial and wound healing biomaterial for tissue engineering applications |
| title_full | Honey: an advanced antimicrobial and wound healing biomaterial for tissue engineering applications |
| title_fullStr | Honey: an advanced antimicrobial and wound healing biomaterial for tissue engineering applications |
| title_full_unstemmed | Honey: an advanced antimicrobial and wound healing biomaterial for tissue engineering applications |
| title_short | Honey: an advanced antimicrobial and wound healing biomaterial for tissue engineering applications |
| title_sort | honey an advanced antimicrobial and wound healing biomaterial for tissue engineering applications |
| topic | Engineering::Mechanical engineering Honey Antimicrobial |
| url | https://hdl.handle.net/10356/163159 |
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