Germline breast cancer susceptibility genes, tumor characteristics, and survival
Mutations in certain genes are known to increase breast cancer risk. We study the relevance of rare protein-truncating variants (PTVs) that may result in loss-of-function in breast cancer susceptibility genes on tumor characteristics and survival in 8852 breast cancer patients of Asian descent.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2022
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| Online Access: | https://hdl.handle.net/10356/163246 |
| _version_ | 1824455159745347584 |
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| author | Ho, Peh Joo Khng, Alexis J. Loh, Hui Wen Ho, Weang-Kee Yip, Cheng Har Mohd-Taib, Nur Aishah Tan, Veronique Kiak Mien Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Ern Yu Lim, Swee Ho Jamaris, Suniza Sim, Yirong Wong, Fuh Yong Ngeow, Joanne Lim, Elaine Hsuen Tai, Mei Chee Wijaya, Eldarina Azfar Lee, Soo Chin Chan, Ching Wan Buhari, Shaik Ahmad Chan, Patrick M. Y. Chen, Juliana J. C. Seah, Jaime Chin Mui Lee, Wai Peng Mok, Chi Wei Lim, Geok Hoon Woo, Evan Kim, Sung-Won Lee, Jong Won Lee, Min Hyuk Park, Sue K. Dunning, Alison M. Easton, Douglas F. Schmidt, Marjanka K. Teo, Soo-Hwang Li, Jingmei Hartman, Mikael |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Ho, Peh Joo Khng, Alexis J. Loh, Hui Wen Ho, Weang-Kee Yip, Cheng Har Mohd-Taib, Nur Aishah Tan, Veronique Kiak Mien Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Ern Yu Lim, Swee Ho Jamaris, Suniza Sim, Yirong Wong, Fuh Yong Ngeow, Joanne Lim, Elaine Hsuen Tai, Mei Chee Wijaya, Eldarina Azfar Lee, Soo Chin Chan, Ching Wan Buhari, Shaik Ahmad Chan, Patrick M. Y. Chen, Juliana J. C. Seah, Jaime Chin Mui Lee, Wai Peng Mok, Chi Wei Lim, Geok Hoon Woo, Evan Kim, Sung-Won Lee, Jong Won Lee, Min Hyuk Park, Sue K. Dunning, Alison M. Easton, Douglas F. Schmidt, Marjanka K. Teo, Soo-Hwang Li, Jingmei Hartman, Mikael |
| author_sort | Ho, Peh Joo |
| collection | NTU |
| description | Mutations in certain genes are known to increase breast cancer risk. We study the relevance of rare protein-truncating variants (PTVs) that may result in loss-of-function in breast cancer susceptibility genes on tumor characteristics and survival in 8852 breast cancer patients of Asian descent. |
| first_indexed | 2025-02-19T03:33:47Z |
| format | Journal Article |
| id | ntu-10356/163246 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:33:47Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1632462023-03-05T16:52:42Z Germline breast cancer susceptibility genes, tumor characteristics, and survival Ho, Peh Joo Khng, Alexis J. Loh, Hui Wen Ho, Weang-Kee Yip, Cheng Har Mohd-Taib, Nur Aishah Tan, Veronique Kiak Mien Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Ern Yu Lim, Swee Ho Jamaris, Suniza Sim, Yirong Wong, Fuh Yong Ngeow, Joanne Lim, Elaine Hsuen Tai, Mei Chee Wijaya, Eldarina Azfar Lee, Soo Chin Chan, Ching Wan Buhari, Shaik Ahmad Chan, Patrick M. Y. Chen, Juliana J. C. Seah, Jaime Chin Mui Lee, Wai Peng Mok, Chi Wei Lim, Geok Hoon Woo, Evan Kim, Sung-Won Lee, Jong Won Lee, Min Hyuk Park, Sue K. Dunning, Alison M. Easton, Douglas F. Schmidt, Marjanka K. Teo, Soo-Hwang Li, Jingmei Hartman, Mikael Lee Kong Chian School of Medicine (LKCMedicine) Tan Tock Seng Hospital Institute of Molecular and Cell Biology, A*STAR National Cancer Centre Singapore Duke-NUS Medical School Science::Medicine Breast Cancer Protein-Truncating Variants Mutations in certain genes are known to increase breast cancer risk. We study the relevance of rare protein-truncating variants (PTVs) that may result in loss-of-function in breast cancer susceptibility genes on tumor characteristics and survival in 8852 breast cancer patients of Asian descent. National Medical Research Council (NMRC) National Research Foundation (NRF) Published version The sequencing and analysis for this project were funded by the European Union's Horizon 2020 Research and Innovation Programme (BRIDGES: grant number 634935) and the Wellcome Trust [grant no: v203477/Z/16/Z]. SGBCC was supported by the National Research Foundation Singapore [NRF-NRFF2017-02, awarded to J Li], NUS start-up Grant [awarded to MH], National University Cancer Institute Singapore (NCIS) Centre Grant [NMRC/CG/NCIS/2010, NMRC/CG/012/2013 and CGAug16M005, awarded to MH], Breast Cancer Prevention Programme (BCPP, awarded to MH), Asian Breast Cancer Research Fund [awarded to MH], and the NMRC Clinician Scientist Award (SI Category) [NMRC/CSASI/0015/2017, awarded to MH], NMRC Centre Grant [CGAug16M012, awarded to EYT]. MyBrCa is funded by research grants from the Malaysian Ministry of Higher Education (UM.C/HlR/MOHE/06), the Wellcome Trust [grant no: v203477/Z/16/Z], and Cancer Research Malaysia. 2022-11-29T06:46:19Z 2022-11-29T06:46:19Z 2021 Journal Article Ho, P. J., Khng, A. J., Loh, H. W., Ho, W., Yip, C. H., Mohd-Taib, N. A., Tan, V. K. M., Tan, B. K., Tan, S., Tan, E. Y., Lim, S. H., Jamaris, S., Sim, Y., Wong, F. Y., Ngeow, J., Lim, E. H., Tai, M. C., Wijaya, E. A., Lee, S. C., ...Hartman, M. (2021). Germline breast cancer susceptibility genes, tumor characteristics, and survival. Genome Medicine, 13(1), 185-. https://dx.doi.org/10.1186/s13073-021-00978-9 1756-994X https://hdl.handle.net/10356/163246 10.1186/s13073-021-00978-9 34857041 2-s2.0-85120725923 1 13 185 en NRF-NRFF2017-02 NMRC/CG/NCIS/2010 NMRC/CG/012/2013 CGAug16M005 NMRC/CSASI/0015/2017 CGAug16M012 Genome Medicine © 2021 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. application/pdf |
| spellingShingle | Science::Medicine Breast Cancer Protein-Truncating Variants Ho, Peh Joo Khng, Alexis J. Loh, Hui Wen Ho, Weang-Kee Yip, Cheng Har Mohd-Taib, Nur Aishah Tan, Veronique Kiak Mien Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Ern Yu Lim, Swee Ho Jamaris, Suniza Sim, Yirong Wong, Fuh Yong Ngeow, Joanne Lim, Elaine Hsuen Tai, Mei Chee Wijaya, Eldarina Azfar Lee, Soo Chin Chan, Ching Wan Buhari, Shaik Ahmad Chan, Patrick M. Y. Chen, Juliana J. C. Seah, Jaime Chin Mui Lee, Wai Peng Mok, Chi Wei Lim, Geok Hoon Woo, Evan Kim, Sung-Won Lee, Jong Won Lee, Min Hyuk Park, Sue K. Dunning, Alison M. Easton, Douglas F. Schmidt, Marjanka K. Teo, Soo-Hwang Li, Jingmei Hartman, Mikael Germline breast cancer susceptibility genes, tumor characteristics, and survival |
| title | Germline breast cancer susceptibility genes, tumor characteristics, and survival |
| title_full | Germline breast cancer susceptibility genes, tumor characteristics, and survival |
| title_fullStr | Germline breast cancer susceptibility genes, tumor characteristics, and survival |
| title_full_unstemmed | Germline breast cancer susceptibility genes, tumor characteristics, and survival |
| title_short | Germline breast cancer susceptibility genes, tumor characteristics, and survival |
| title_sort | germline breast cancer susceptibility genes tumor characteristics and survival |
| topic | Science::Medicine Breast Cancer Protein-Truncating Variants |
| url | https://hdl.handle.net/10356/163246 |
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