Self-assembled Aza-boron-dipyrromethene for ferroptosis-boosted sonodynamic therapy
The presence of apoptosis inhibition proteins renders the cancer cells resistant to apoptosis, severely compromising the antitumor efficacy of sonodynamic therapy (SDT). Here, an intelligent anticancer nanoplatform based on an Aza-boron-dipyrromethene dye (denoted as Aza-BDY) is elaborately establis...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/163323 |
| _version_ | 1826127544032690176 |
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| author | You, Changwen Li, Xingguang Wang, Dongqiong Chen, Hongzhong Liang, Lei Chen, Yu Zhao, Yanli Xiang, Huijing |
| author2 | School of Chemistry, Chemical Engineering and Biotechnology |
| author_facet | School of Chemistry, Chemical Engineering and Biotechnology You, Changwen Li, Xingguang Wang, Dongqiong Chen, Hongzhong Liang, Lei Chen, Yu Zhao, Yanli Xiang, Huijing |
| author_sort | You, Changwen |
| collection | NTU |
| description | The presence of apoptosis inhibition proteins renders the cancer cells resistant to apoptosis, severely compromising the antitumor efficacy of sonodynamic therapy (SDT). Here, an intelligent anticancer nanoplatform based on an Aza-boron-dipyrromethene dye (denoted as Aza-BDY) is elaborately established for ferroptosis augmented SDT through cysteine (Cys) starvation. After endocytosis by tumor cells, Aza-BDY serves as both a ferroptosis inducing agent and a sonosensitizer for tumor treatment. The specific Cys response facilitates the disruption of redox homeostasis and initiation of cellular ferroptosis. Meanwhile, the released sonosensitizer causes efficient SDT and augments ferroptosis under ultrasound irradiation. Detailed in vitro and in vivo investigations demonstrate that the synergistic effect of Cys depletion and singlet oxygen (1 O2 ) generation significantly induces cancer-cell death and suppresses tumor proliferation with a high inhibition rate of 97.5 %. |
| first_indexed | 2024-10-01T07:10:17Z |
| format | Journal Article |
| id | ntu-10356/163323 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:10:17Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1633232023-06-21T08:33:47Z Self-assembled Aza-boron-dipyrromethene for ferroptosis-boosted sonodynamic therapy You, Changwen Li, Xingguang Wang, Dongqiong Chen, Hongzhong Liang, Lei Chen, Yu Zhao, Yanli Xiang, Huijing School of Chemistry, Chemical Engineering and Biotechnology Science::Chemistry Cysteine Starvation Ferroptosis The presence of apoptosis inhibition proteins renders the cancer cells resistant to apoptosis, severely compromising the antitumor efficacy of sonodynamic therapy (SDT). Here, an intelligent anticancer nanoplatform based on an Aza-boron-dipyrromethene dye (denoted as Aza-BDY) is elaborately established for ferroptosis augmented SDT through cysteine (Cys) starvation. After endocytosis by tumor cells, Aza-BDY serves as both a ferroptosis inducing agent and a sonosensitizer for tumor treatment. The specific Cys response facilitates the disruption of redox homeostasis and initiation of cellular ferroptosis. Meanwhile, the released sonosensitizer causes efficient SDT and augments ferroptosis under ultrasound irradiation. Detailed in vitro and in vivo investigations demonstrate that the synergistic effect of Cys depletion and singlet oxygen (1 O2 ) generation significantly induces cancer-cell death and suppresses tumor proliferation with a high inhibition rate of 97.5 %. Agency for Science, Technology and Research (A*STAR) National Research Foundation (NRF) We greatly acknowledge the financial support from the National Natural Science Foundation of China (32171391 and 51902336), the Shanghai Science and Technology Program (21010500100), the Basic Research Program of Shanghai Municipal Government (21JC1406002), the Shanghai Rising-Star Program (22QA1403600), the Singapore National Research Foundation Investigatorship (NRF-NRFI2018-03), and the Singapore Agency for Science, Technology and Research (A*STAR) AME IRG grant (A20E5c0081). 2022-12-02T04:54:06Z 2022-12-02T04:54:06Z 2022 Journal Article You, C., Li, X., Wang, D., Chen, H., Liang, L., Chen, Y., Zhao, Y. & Xiang, H. (2022). Self-assembled Aza-boron-dipyrromethene for ferroptosis-boosted sonodynamic therapy. Angewandte Chemie International Edition, 61(41), e202210174-. https://dx.doi.org/10.1002/anie.202210174 1433-7851 https://hdl.handle.net/10356/163323 10.1002/anie.202210174 35981223 2-s2.0-85137184045 41 61 e202210174 en NRF-NRFI2018-03 A20E5c0081 Angewandte Chemie International Edition © 2022 Wiley-VCH GmbH. All rights reserved. |
| spellingShingle | Science::Chemistry Cysteine Starvation Ferroptosis You, Changwen Li, Xingguang Wang, Dongqiong Chen, Hongzhong Liang, Lei Chen, Yu Zhao, Yanli Xiang, Huijing Self-assembled Aza-boron-dipyrromethene for ferroptosis-boosted sonodynamic therapy |
| title | Self-assembled Aza-boron-dipyrromethene for ferroptosis-boosted sonodynamic therapy |
| title_full | Self-assembled Aza-boron-dipyrromethene for ferroptosis-boosted sonodynamic therapy |
| title_fullStr | Self-assembled Aza-boron-dipyrromethene for ferroptosis-boosted sonodynamic therapy |
| title_full_unstemmed | Self-assembled Aza-boron-dipyrromethene for ferroptosis-boosted sonodynamic therapy |
| title_short | Self-assembled Aza-boron-dipyrromethene for ferroptosis-boosted sonodynamic therapy |
| title_sort | self assembled aza boron dipyrromethene for ferroptosis boosted sonodynamic therapy |
| topic | Science::Chemistry Cysteine Starvation Ferroptosis |
| url | https://hdl.handle.net/10356/163323 |
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