Gut microbiome responses to dietary intervention with hypocholesterolemic vegetable oils
Hypercholesterolemia is becoming a problem with increasing significance. Dietary vegetable oils may help to improve this condition due to presence of phytonutrients with potentially synergistic cholesterol-lowering effects. The objective of this 8-week double-blinded randomized clinical trial was to...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2022
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| Online Access: | https://hdl.handle.net/10356/163376 |
| _version_ | 1811695829954592768 |
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| author | Lim, Rachel Rui Xia Park, Mi Ae Wong, Long Hui Haldar, Sumanto Lim, Kevin Junliang Nagarajan, Niranjan Henry, Christiani Jeyakumar Jiang, Yuan Rong Moskvin, Oleg Vladimirovich |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Lim, Rachel Rui Xia Park, Mi Ae Wong, Long Hui Haldar, Sumanto Lim, Kevin Junliang Nagarajan, Niranjan Henry, Christiani Jeyakumar Jiang, Yuan Rong Moskvin, Oleg Vladimirovich |
| author_sort | Lim, Rachel Rui Xia |
| collection | NTU |
| description | Hypercholesterolemia is becoming a problem with increasing significance. Dietary vegetable oils may help to improve this condition due to presence of phytonutrients with potentially synergistic cholesterol-lowering effects. The objective of this 8-week double-blinded randomized clinical trial was to investigate the effects of consuming 30 g of two different blended cooking oils, rich in omega-3 alpha-linolenic acid and phytonutrients, or refined olive oil on the intestinal microbiota in 126 volunteers with borderline hypercholesterolemia. Multi-factor analysis of relationships between the gut microbiota composition at various taxonomic ranks and the clinical trial parameters revealed the association between beneficial effects of the dietary intervention on the blood lipid profile with abundance of Clostridia class of the gut microbiota. This microbiota feature was upregulated in the course of the dietary intervention and associated with various plasma markers of metabolic health status, such as Triglycerides, Apolipoprotein B and Total Cholesterol to HDL ratio in a beneficial way. The relative abundance of a single species-Clostridium leptum-highly increased during the dietary intervention in all the three study groups. The oil blend with the highest concentration of omega-3 PUFA is associated with faster and more robust responses of the intestinal microbiota, including elevation of alpha-diversity. Butyrate production is being discussed as a plausible process mediating the observed beneficial influence on the plasma lipid profile. Causal mediation analysis suggested that Clostridium genus rather than the higher rank of the phylogeny-Clostridia class-may be involved in the diet-induced improvements of the blood lipid profile. |
| first_indexed | 2024-10-01T07:29:42Z |
| format | Journal Article |
| id | ntu-10356/163376 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:29:42Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1633762023-02-28T20:09:18Z Gut microbiome responses to dietary intervention with hypocholesterolemic vegetable oils Lim, Rachel Rui Xia Park, Mi Ae Wong, Long Hui Haldar, Sumanto Lim, Kevin Junliang Nagarajan, Niranjan Henry, Christiani Jeyakumar Jiang, Yuan Rong Moskvin, Oleg Vladimirovich School of Physical and Mathematical Sciences Centre for Translational Medicine, NUS Science::Chemistry::Biochemistry Apolipoprotein B Cholesterol Blood Level Hypercholesterolemia is becoming a problem with increasing significance. Dietary vegetable oils may help to improve this condition due to presence of phytonutrients with potentially synergistic cholesterol-lowering effects. The objective of this 8-week double-blinded randomized clinical trial was to investigate the effects of consuming 30 g of two different blended cooking oils, rich in omega-3 alpha-linolenic acid and phytonutrients, or refined olive oil on the intestinal microbiota in 126 volunteers with borderline hypercholesterolemia. Multi-factor analysis of relationships between the gut microbiota composition at various taxonomic ranks and the clinical trial parameters revealed the association between beneficial effects of the dietary intervention on the blood lipid profile with abundance of Clostridia class of the gut microbiota. This microbiota feature was upregulated in the course of the dietary intervention and associated with various plasma markers of metabolic health status, such as Triglycerides, Apolipoprotein B and Total Cholesterol to HDL ratio in a beneficial way. The relative abundance of a single species-Clostridium leptum-highly increased during the dietary intervention in all the three study groups. The oil blend with the highest concentration of omega-3 PUFA is associated with faster and more robust responses of the intestinal microbiota, including elevation of alpha-diversity. Butyrate production is being discussed as a plausible process mediating the observed beneficial influence on the plasma lipid profile. Causal mediation analysis suggested that Clostridium genus rather than the higher rank of the phylogeny-Clostridia class-may be involved in the diet-induced improvements of the blood lipid profile. Published version 2022-12-05T05:03:27Z 2022-12-05T05:03:27Z 2022 Journal Article Lim, R. R. X., Park, M. A., Wong, L. H., Haldar, S., Lim, K. J., Nagarajan, N., Henry, C. J., Jiang, Y. R. & Moskvin, O. V. (2022). Gut microbiome responses to dietary intervention with hypocholesterolemic vegetable oils. Npj Biofilms and Microbiomes, 8(1), 24-. https://dx.doi.org/10.1038/s41522-022-00287-y 2055-5008 https://hdl.handle.net/10356/163376 10.1038/s41522-022-00287-y 35411007 2-s2.0-85128084792 1 8 24 en npj Biofilms and Microbiomes © The Author(s) 2022. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons. org/licenses/by/4.0/. application/pdf |
| spellingShingle | Science::Chemistry::Biochemistry Apolipoprotein B Cholesterol Blood Level Lim, Rachel Rui Xia Park, Mi Ae Wong, Long Hui Haldar, Sumanto Lim, Kevin Junliang Nagarajan, Niranjan Henry, Christiani Jeyakumar Jiang, Yuan Rong Moskvin, Oleg Vladimirovich Gut microbiome responses to dietary intervention with hypocholesterolemic vegetable oils |
| title | Gut microbiome responses to dietary intervention with hypocholesterolemic vegetable oils |
| title_full | Gut microbiome responses to dietary intervention with hypocholesterolemic vegetable oils |
| title_fullStr | Gut microbiome responses to dietary intervention with hypocholesterolemic vegetable oils |
| title_full_unstemmed | Gut microbiome responses to dietary intervention with hypocholesterolemic vegetable oils |
| title_short | Gut microbiome responses to dietary intervention with hypocholesterolemic vegetable oils |
| title_sort | gut microbiome responses to dietary intervention with hypocholesterolemic vegetable oils |
| topic | Science::Chemistry::Biochemistry Apolipoprotein B Cholesterol Blood Level |
| url | https://hdl.handle.net/10356/163376 |
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