Pharmacological perturbation of thiamine metabolism sensitizes Pseudomonas aeruginosa to multiple antibacterial agents

Pharmacological perturbation of thiamine metabolism sensitizes Pseudomonas aeruginosa to multiple antibacterial agents

New therapeutic concepts are critically needed for carbapenem-resistant Pseudomonas aeruginosa, an opportunistic pathogen particularly recalcitrant to antibiotics. The screening of around 230,000 small molecules yielded a very low hit rate of 0.002% after triaging for known antibiotics. The only nov...

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Bibliographic Details
Main Authors:	Kim, Hyung Jun, Li, Yingying, Zimmermann, Michael, Lee, Yunmi, Lim, Hui Wen, Tan, Alvin Swee Leong, Choi, Inhee, Ko, Yoonae, Lee, Sangchul, Seo, Jeong Jea, Seo, Mooyoung, Jeon, Hee Kyoung, Cechetto, Jonathan, Yam, Joey Kuok Hoong, Yang, Liang, Sauer, Uwe, Jang, Soojin, Pethe, Kevin
Other Authors:	Lee Kong Chian School of Medicine (LKCMedicine)
Format:	Journal Article
Language:	English
Published:	2022
Subjects:	Science::Biological sciences::Biochemistry Vitamin B1 Oxythiamine Antimetabolite Antibacterial Fluorouracil Auranofin Synthetic Lethal Interactions Antibacterial Screening ESKAPE Pathogens
Online Access:	https://hdl.handle.net/10356/163407

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