BF₃-promoted reactions of α-amino acetals with alkynes to 2,5-disubstituted pyrroles
An efficient BF₃-promoted cyclization of α-amino acetals with alkynes for the assembly of substituted pyrroles has been developed. This cascade process uses easily accessible α-amino acetals as raw materials and can be achieved under mild conditions through a simple metal-free operation.
Main Authors: | , , , , |
---|---|
Other Authors: | |
Format: | Journal Article |
Language: | English |
Published: |
2022
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/163494 |
_version_ | 1811696505385385984 |
---|---|
author | Gao, Zhi-Yuan He, Yu Li, Lan-Yang Tian, Jie-Sheng Loh, Teck-Peng |
author2 | School of Physical and Mathematical Sciences |
author_facet | School of Physical and Mathematical Sciences Gao, Zhi-Yuan He, Yu Li, Lan-Yang Tian, Jie-Sheng Loh, Teck-Peng |
author_sort | Gao, Zhi-Yuan |
collection | NTU |
description | An efficient BF₃-promoted cyclization of α-amino acetals with alkynes for the assembly of substituted pyrroles has been developed. This cascade process uses easily accessible α-amino acetals as raw materials and can be achieved under mild conditions through a simple metal-free operation. |
first_indexed | 2024-10-01T07:40:26Z |
format | Journal Article |
id | ntu-10356/163494 |
institution | Nanyang Technological University |
language | English |
last_indexed | 2024-10-01T07:40:26Z |
publishDate | 2022 |
record_format | dspace |
spelling | ntu-10356/1634942022-12-07T07:39:24Z BF₃-promoted reactions of α-amino acetals with alkynes to 2,5-disubstituted pyrroles Gao, Zhi-Yuan He, Yu Li, Lan-Yang Tian, Jie-Sheng Loh, Teck-Peng School of Physical and Mathematical Sciences Science::Chemistry Cascade Process Cyclizations An efficient BF₃-promoted cyclization of α-amino acetals with alkynes for the assembly of substituted pyrroles has been developed. This cascade process uses easily accessible α-amino acetals as raw materials and can be achieved under mild conditions through a simple metal-free operation. Ministry of Education (MOE) The authors gratefully acknowledge the generous financial support from Nanjing Tech University, the Fundamental Research Funds for the Central Universities (D5000210701), and Tier 1 Grant M4012045.110 (RG12/18-S) from the Ministry of Education of Singapore. 2022-12-07T07:39:24Z 2022-12-07T07:39:24Z 2022 Journal Article Gao, Z., He, Y., Li, L., Tian, J. & Loh, T. (2022). BF₃-promoted reactions of α-amino acetals with alkynes to 2,5-disubstituted pyrroles. Organic Chemistry Frontiers, 9(12), 3317-3321. https://dx.doi.org/10.1039/d2qo00405d 2052-4129 https://hdl.handle.net/10356/163494 10.1039/d2qo00405d 2-s2.0-85133618180 12 9 3317 3321 en M4012045.110 (RG12/18-S) Organic Chemistry Frontiers © 2022 the Partner Organisations (The Chinese Chemical Society, Shanghai Institute of Organic Chemistry, and Royal Society of Chemistry). All rights reserved. |
spellingShingle | Science::Chemistry Cascade Process Cyclizations Gao, Zhi-Yuan He, Yu Li, Lan-Yang Tian, Jie-Sheng Loh, Teck-Peng BF₃-promoted reactions of α-amino acetals with alkynes to 2,5-disubstituted pyrroles |
title | BF₃-promoted reactions of α-amino acetals with alkynes to 2,5-disubstituted pyrroles |
title_full | BF₃-promoted reactions of α-amino acetals with alkynes to 2,5-disubstituted pyrroles |
title_fullStr | BF₃-promoted reactions of α-amino acetals with alkynes to 2,5-disubstituted pyrroles |
title_full_unstemmed | BF₃-promoted reactions of α-amino acetals with alkynes to 2,5-disubstituted pyrroles |
title_short | BF₃-promoted reactions of α-amino acetals with alkynes to 2,5-disubstituted pyrroles |
title_sort | bf₃ promoted reactions of α amino acetals with alkynes to 2 5 disubstituted pyrroles |
topic | Science::Chemistry Cascade Process Cyclizations |
url | https://hdl.handle.net/10356/163494 |
work_keys_str_mv | AT gaozhiyuan bf3promotedreactionsofaaminoacetalswithalkynesto25disubstitutedpyrroles AT heyu bf3promotedreactionsofaaminoacetalswithalkynesto25disubstitutedpyrroles AT lilanyang bf3promotedreactionsofaaminoacetalswithalkynesto25disubstitutedpyrroles AT tianjiesheng bf3promotedreactionsofaaminoacetalswithalkynesto25disubstitutedpyrroles AT lohteckpeng bf3promotedreactionsofaaminoacetalswithalkynesto25disubstitutedpyrroles |