SARS-CoV-2 mRNA vaccination and Graves' disease: a report of 12 cases and review of the literature
Context and objective: Thyroid autoimmunity has been reported to be associated with severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) and the SARS-CoV-2 vaccination recently. We report a series of patients who presented with new onset or relapse of Graves’ disease-related hyperthyroidism s...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/163887 |
| _version_ | 1811696034296889344 |
|---|---|
| author | Chee, Ying Jie Liew, Huiling Hoi, Wai Han Lee, Yingshan Lim, Brenda Chin, Han Xin Lai, Ray Tian Rui Koh, Yunqing Tham, Michelle Seow, Cherng Jye Quek, Zhi Han Chen, Abel Weiliang Quek, Timothy Peng Lim Tan, Alvin Wai Kit Dalan, Rinkoo |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Chee, Ying Jie Liew, Huiling Hoi, Wai Han Lee, Yingshan Lim, Brenda Chin, Han Xin Lai, Ray Tian Rui Koh, Yunqing Tham, Michelle Seow, Cherng Jye Quek, Zhi Han Chen, Abel Weiliang Quek, Timothy Peng Lim Tan, Alvin Wai Kit Dalan, Rinkoo |
| author_sort | Chee, Ying Jie |
| collection | NTU |
| description | Context and objective: Thyroid autoimmunity has been reported to be associated with severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) and the SARS-CoV-2 vaccination recently. We report a series of patients who presented with new onset or relapse of Graves’ disease-related hyperthyroidism shortly after receiving the SARS-CoV-2 messenger RNA (mRNA) vaccine at a single tertiary institution in Singapore. Methods and results: We describe 12 patients who developed hyperthyroidism within a relatively short interval (median onset, 17 [range, 5-63] days) after receiving the SARS-CoV-2 mRNA vaccine. The majority were females (11/12) with median age of 35.5 (range, 22-74) years. Six patients had new-onset hyperthyroidism, whereas the other 6 had relapse of previously well-controlled Graves’ disease. TSH receptor antibody concentrations ranged from 2.4 to 32 IU/L. The majority of the patients were able to go for the second dose of the vaccine without any further exacerbations. Literature review revealed 21 other similar cases reported from across the world. Conclusion: Our case series provides insight into the characteristics of individuals in whom Graves’ disease was triggered by the SARS-CoV-2 vaccination. Clinicians need to be vigilant of precipitation or exacerbation of autoimmune thyroid disorders in predisposed individuals after exposure to the SARS-CoV-2 vaccination. Further epidemiological and mechanistic studies are required to elucidate the possible associations between the SARS-CoV-2 vaccines and the development of thyroid autoimmunity. |
| first_indexed | 2024-10-01T07:32:57Z |
| format | Journal Article |
| id | ntu-10356/163887 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:32:57Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1638872022-12-21T04:53:26Z SARS-CoV-2 mRNA vaccination and Graves' disease: a report of 12 cases and review of the literature Chee, Ying Jie Liew, Huiling Hoi, Wai Han Lee, Yingshan Lim, Brenda Chin, Han Xin Lai, Ray Tian Rui Koh, Yunqing Tham, Michelle Seow, Cherng Jye Quek, Zhi Han Chen, Abel Weiliang Quek, Timothy Peng Lim Tan, Alvin Wai Kit Dalan, Rinkoo Lee Kong Chian School of Medicine (LKCMedicine) Tan Tock Seng Hospital Science::Medicine Hyperthyroidism Graves' Disease Context and objective: Thyroid autoimmunity has been reported to be associated with severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) and the SARS-CoV-2 vaccination recently. We report a series of patients who presented with new onset or relapse of Graves’ disease-related hyperthyroidism shortly after receiving the SARS-CoV-2 messenger RNA (mRNA) vaccine at a single tertiary institution in Singapore. Methods and results: We describe 12 patients who developed hyperthyroidism within a relatively short interval (median onset, 17 [range, 5-63] days) after receiving the SARS-CoV-2 mRNA vaccine. The majority were females (11/12) with median age of 35.5 (range, 22-74) years. Six patients had new-onset hyperthyroidism, whereas the other 6 had relapse of previously well-controlled Graves’ disease. TSH receptor antibody concentrations ranged from 2.4 to 32 IU/L. The majority of the patients were able to go for the second dose of the vaccine without any further exacerbations. Literature review revealed 21 other similar cases reported from across the world. Conclusion: Our case series provides insight into the characteristics of individuals in whom Graves’ disease was triggered by the SARS-CoV-2 vaccination. Clinicians need to be vigilant of precipitation or exacerbation of autoimmune thyroid disorders in predisposed individuals after exposure to the SARS-CoV-2 vaccination. Further epidemiological and mechanistic studies are required to elucidate the possible associations between the SARS-CoV-2 vaccines and the development of thyroid autoimmunity. Ministry of Health (MOH) R.D. is supported in part by Ministry of Health, Clinician Scientist Award (MOH-000014), NHG-LKC Clinician Scientist Fellowship. A.W.K.T. is supported by the NHG-LKC Clinician Scientist Fellowship. 2022-12-21T04:53:26Z 2022-12-21T04:53:26Z 2022 Journal Article Chee, Y. J., Liew, H., Hoi, W. H., Lee, Y., Lim, B., Chin, H. X., Lai, R. T. R., Koh, Y., Tham, M., Seow, C. J., Quek, Z. H., Chen, A. W., Quek, T. P. L., Tan, A. W. K. & Dalan, R. (2022). SARS-CoV-2 mRNA vaccination and Graves' disease: a report of 12 cases and review of the literature. The Journal of Clinical Endocrinology & Metabolism, 107(6), e2324-e2330. https://dx.doi.org/10.1210/clinem/dgac119 0021-972X https://hdl.handle.net/10356/163887 10.1210/clinem/dgac119 35235663 2-s2.0-85130643551 6 107 e2324 e2330 en MOH-000014 The Journal of Clinical Endocrinology & Metabolism © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. |
| spellingShingle | Science::Medicine Hyperthyroidism Graves' Disease Chee, Ying Jie Liew, Huiling Hoi, Wai Han Lee, Yingshan Lim, Brenda Chin, Han Xin Lai, Ray Tian Rui Koh, Yunqing Tham, Michelle Seow, Cherng Jye Quek, Zhi Han Chen, Abel Weiliang Quek, Timothy Peng Lim Tan, Alvin Wai Kit Dalan, Rinkoo SARS-CoV-2 mRNA vaccination and Graves' disease: a report of 12 cases and review of the literature |
| title | SARS-CoV-2 mRNA vaccination and Graves' disease: a report of 12 cases and review of the literature |
| title_full | SARS-CoV-2 mRNA vaccination and Graves' disease: a report of 12 cases and review of the literature |
| title_fullStr | SARS-CoV-2 mRNA vaccination and Graves' disease: a report of 12 cases and review of the literature |
| title_full_unstemmed | SARS-CoV-2 mRNA vaccination and Graves' disease: a report of 12 cases and review of the literature |
| title_short | SARS-CoV-2 mRNA vaccination and Graves' disease: a report of 12 cases and review of the literature |
| title_sort | sars cov 2 mrna vaccination and graves disease a report of 12 cases and review of the literature |
| topic | Science::Medicine Hyperthyroidism Graves' Disease |
| url | https://hdl.handle.net/10356/163887 |
| work_keys_str_mv | AT cheeyingjie sarscov2mrnavaccinationandgravesdiseaseareportof12casesandreviewoftheliterature AT liewhuiling sarscov2mrnavaccinationandgravesdiseaseareportof12casesandreviewoftheliterature AT hoiwaihan sarscov2mrnavaccinationandgravesdiseaseareportof12casesandreviewoftheliterature AT leeyingshan sarscov2mrnavaccinationandgravesdiseaseareportof12casesandreviewoftheliterature AT limbrenda sarscov2mrnavaccinationandgravesdiseaseareportof12casesandreviewoftheliterature AT chinhanxin sarscov2mrnavaccinationandgravesdiseaseareportof12casesandreviewoftheliterature AT lairaytianrui sarscov2mrnavaccinationandgravesdiseaseareportof12casesandreviewoftheliterature AT kohyunqing sarscov2mrnavaccinationandgravesdiseaseareportof12casesandreviewoftheliterature AT thammichelle sarscov2mrnavaccinationandgravesdiseaseareportof12casesandreviewoftheliterature AT seowcherngjye sarscov2mrnavaccinationandgravesdiseaseareportof12casesandreviewoftheliterature AT quekzhihan sarscov2mrnavaccinationandgravesdiseaseareportof12casesandreviewoftheliterature AT chenabelweiliang sarscov2mrnavaccinationandgravesdiseaseareportof12casesandreviewoftheliterature AT quektimothypenglim sarscov2mrnavaccinationandgravesdiseaseareportof12casesandreviewoftheliterature AT tanalvinwaikit sarscov2mrnavaccinationandgravesdiseaseareportof12casesandreviewoftheliterature AT dalanrinkoo sarscov2mrnavaccinationandgravesdiseaseareportof12casesandreviewoftheliterature |