Tumor microenvironment-activated theranostic nanoreactor for NIR-II photoacoustic imaging-guided tumor-specific photothermal therapy
Theranostic agents that can be sensitively and specifically activated by the tumor microenvironment (TME) have recently attracted considerable attention. In this study, TME-activatable 3,3′,5,5′-tetramethylbenzidine (TMB)-copper peroxide (CuO2)@poly(lactic-co-glycolic acid) (PLGA)@red blood cell mem...
| Main Authors: | , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/163988 |
| _version_ | 1826110951675396096 |
|---|---|
| author | Yang, Nan Li, Hui Cao, Changyu Zhao, Lei Song, Xuejiao Wang, Wenjun Xu, Wenjing Zhang, Yewei Chen, Peng Dong, Xiaochen |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Yang, Nan Li, Hui Cao, Changyu Zhao, Lei Song, Xuejiao Wang, Wenjun Xu, Wenjing Zhang, Yewei Chen, Peng Dong, Xiaochen |
| author_sort | Yang, Nan |
| collection | NTU |
| description | Theranostic agents that can be sensitively and specifically activated by the tumor microenvironment (TME) have recently attracted considerable attention. In this study, TME-activatable 3,3′,5,5′-tetramethylbenzidine (TMB)-copper peroxide (CuO2)@poly(lactic-co-glycolic acid) (PLGA)@red blood cell membrane (RBCM) (TCPR) nanoparticles (NPs) for second near-infrared photoacoustic imaging-guided tumor-specific photothermal therapy were developed by co-loading CuO2 NPs and TMB into PLGA camouflaged by RBCMs. As an efficient H2O2 supplier, once exposed to a proton-rich TME, CuO2 NPs can generate H2O2 and Cu2+, which are further reduced to Cu+ by endogenous glutathione. Subsequently, the Cu+-mediated Fenton-like reaction produces cytotoxic ·OH to kill the cancer cells and induce TMB-mediated photoacoustic and photothermal effects. Combined with the RBCM modification-prolonged blood circulation, TCPR NPs display excellent specificity and efficiency in suppressing tumor growth, paving the way for more accurate, safe, and efficient cancer theranostics. |
| first_indexed | 2024-10-01T02:42:58Z |
| format | Journal Article |
| id | ntu-10356/163988 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:42:58Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1639882023-03-05T16:52:28Z Tumor microenvironment-activated theranostic nanoreactor for NIR-II photoacoustic imaging-guided tumor-specific photothermal therapy Yang, Nan Li, Hui Cao, Changyu Zhao, Lei Song, Xuejiao Wang, Wenjun Xu, Wenjing Zhang, Yewei Chen, Peng Dong, Xiaochen School of Chemical and Biomedical Engineering Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Nanoparticles Photoacoustic Imaging Theranostic agents that can be sensitively and specifically activated by the tumor microenvironment (TME) have recently attracted considerable attention. In this study, TME-activatable 3,3′,5,5′-tetramethylbenzidine (TMB)-copper peroxide (CuO2)@poly(lactic-co-glycolic acid) (PLGA)@red blood cell membrane (RBCM) (TCPR) nanoparticles (NPs) for second near-infrared photoacoustic imaging-guided tumor-specific photothermal therapy were developed by co-loading CuO2 NPs and TMB into PLGA camouflaged by RBCMs. As an efficient H2O2 supplier, once exposed to a proton-rich TME, CuO2 NPs can generate H2O2 and Cu2+, which are further reduced to Cu+ by endogenous glutathione. Subsequently, the Cu+-mediated Fenton-like reaction produces cytotoxic ·OH to kill the cancer cells and induce TMB-mediated photoacoustic and photothermal effects. Combined with the RBCM modification-prolonged blood circulation, TCPR NPs display excellent specificity and efficiency in suppressing tumor growth, paving the way for more accurate, safe, and efficient cancer theranostics. Published version This work was supported by the National Natural Science Foundation (NNSF) of China (Grant Nos.: 62120106002, 51803091, 61935004, 22175089), Jiangsu Province Policy Guidance Plan (BZ2019014), Jiangsu Provincial key research and development plan (BE2021711), NSF of Shandong Province (ZR2020KB018), Taishan scholars construction special fund of Shandong Province, Natural Science Foundation of Ningbo (202003N40448), and the Jiangsu postgraduate research innovation program (KYCX21_1103). 2022-12-28T05:18:45Z 2022-12-28T05:18:45Z 2022 Journal Article Yang, N., Li, H., Cao, C., Zhao, L., Song, X., Wang, W., Xu, W., Zhang, Y., Chen, P. & Dong, X. (2022). Tumor microenvironment-activated theranostic nanoreactor for NIR-II photoacoustic imaging-guided tumor-specific photothermal therapy. Fundamental Research. https://dx.doi.org/10.1016/j.fmre.2022.04.021 2096-9457 https://hdl.handle.net/10356/163988 10.1016/j.fmre.2022.04.021 2-s2.0-85130554596 en Fundamental Research © 2022 The Authors. Publishing Services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). application/pdf |
| spellingShingle | Science::Medicine Nanoparticles Photoacoustic Imaging Yang, Nan Li, Hui Cao, Changyu Zhao, Lei Song, Xuejiao Wang, Wenjun Xu, Wenjing Zhang, Yewei Chen, Peng Dong, Xiaochen Tumor microenvironment-activated theranostic nanoreactor for NIR-II photoacoustic imaging-guided tumor-specific photothermal therapy |
| title | Tumor microenvironment-activated theranostic nanoreactor for NIR-II photoacoustic imaging-guided tumor-specific photothermal therapy |
| title_full | Tumor microenvironment-activated theranostic nanoreactor for NIR-II photoacoustic imaging-guided tumor-specific photothermal therapy |
| title_fullStr | Tumor microenvironment-activated theranostic nanoreactor for NIR-II photoacoustic imaging-guided tumor-specific photothermal therapy |
| title_full_unstemmed | Tumor microenvironment-activated theranostic nanoreactor for NIR-II photoacoustic imaging-guided tumor-specific photothermal therapy |
| title_short | Tumor microenvironment-activated theranostic nanoreactor for NIR-II photoacoustic imaging-guided tumor-specific photothermal therapy |
| title_sort | tumor microenvironment activated theranostic nanoreactor for nir ii photoacoustic imaging guided tumor specific photothermal therapy |
| topic | Science::Medicine Nanoparticles Photoacoustic Imaging |
| url | https://hdl.handle.net/10356/163988 |
| work_keys_str_mv | AT yangnan tumormicroenvironmentactivatedtheranosticnanoreactorforniriiphotoacousticimagingguidedtumorspecificphotothermaltherapy AT lihui tumormicroenvironmentactivatedtheranosticnanoreactorforniriiphotoacousticimagingguidedtumorspecificphotothermaltherapy AT caochangyu tumormicroenvironmentactivatedtheranosticnanoreactorforniriiphotoacousticimagingguidedtumorspecificphotothermaltherapy AT zhaolei tumormicroenvironmentactivatedtheranosticnanoreactorforniriiphotoacousticimagingguidedtumorspecificphotothermaltherapy AT songxuejiao tumormicroenvironmentactivatedtheranosticnanoreactorforniriiphotoacousticimagingguidedtumorspecificphotothermaltherapy AT wangwenjun tumormicroenvironmentactivatedtheranosticnanoreactorforniriiphotoacousticimagingguidedtumorspecificphotothermaltherapy AT xuwenjing tumormicroenvironmentactivatedtheranosticnanoreactorforniriiphotoacousticimagingguidedtumorspecificphotothermaltherapy AT zhangyewei tumormicroenvironmentactivatedtheranosticnanoreactorforniriiphotoacousticimagingguidedtumorspecificphotothermaltherapy AT chenpeng tumormicroenvironmentactivatedtheranosticnanoreactorforniriiphotoacousticimagingguidedtumorspecificphotothermaltherapy AT dongxiaochen tumormicroenvironmentactivatedtheranosticnanoreactorforniriiphotoacousticimagingguidedtumorspecificphotothermaltherapy |