State-of-the-art self-luminescence: a win-win situation
Self-luminescence, which eliminates the real-time external optical excitation, can effectively avoid background autofluorescence in photoluminescence, endowing with ultrahigh signal-to-noise ratio and sensitivity in bioassay. Furthermore, in situ generated and emitted photons have been applied to de...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://hdl.handle.net/10356/164471 |
| _version_ | 1826123922816368640 |
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| author | Yang, Mingwang Zeng, Ziling Lam, Jacky W. Y. Fan, Jiangli Pu, Kanyi Tang, Ben Zhong |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Yang, Mingwang Zeng, Ziling Lam, Jacky W. Y. Fan, Jiangli Pu, Kanyi Tang, Ben Zhong |
| author_sort | Yang, Mingwang |
| collection | NTU |
| description | Self-luminescence, which eliminates the real-time external optical excitation, can effectively avoid background autofluorescence in photoluminescence, endowing with ultrahigh signal-to-noise ratio and sensitivity in bioassay. Furthermore, in situ generated and emitted photons have been applied to develop excitation-free diagnostics and therapeutic agents against deeply seated diseases. "Enhanced" self-luminescence, referring to the aggregation-induced emission (AIE)-integrated self-luminescence systems, is endowed with not only the above merits but also other superiorities including stronger luminous brightness and longer half-life compared with "traditional" self-luminescence platforms. As an emerging and booming hotspot, the "enhanced" self-luminescence facilitated by the win-win cooperation of the aggregation-induced emission and self-luminescent techniques has become a powerful tool for interdisciplinary research. This tutorial review summarizes the advancements of AIE-assisted self-luminescence including chemiluminescence and afterglow imaging, starting from the discussion on the design and working principles, luminescent mechanisms of self-luminescence fuels, versatile integrated approaches and advantages, and a broad range of representative examples in biosensors and oncotherapy. Finally, the current challenges and perspectives are discussed to further actuate the development of "enhanced" self-luminescence agents for biomedical diagnosis and treatment. |
| first_indexed | 2024-10-01T06:12:15Z |
| format | Journal Article |
| id | ntu-10356/164471 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:12:15Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1644712023-01-27T07:48:44Z State-of-the-art self-luminescence: a win-win situation Yang, Mingwang Zeng, Ziling Lam, Jacky W. Y. Fan, Jiangli Pu, Kanyi Tang, Ben Zhong School of Chemical and Biomedical Engineering Engineering::Bioengineering Biosensing Techniques Luminescence Self-luminescence, which eliminates the real-time external optical excitation, can effectively avoid background autofluorescence in photoluminescence, endowing with ultrahigh signal-to-noise ratio and sensitivity in bioassay. Furthermore, in situ generated and emitted photons have been applied to develop excitation-free diagnostics and therapeutic agents against deeply seated diseases. "Enhanced" self-luminescence, referring to the aggregation-induced emission (AIE)-integrated self-luminescence systems, is endowed with not only the above merits but also other superiorities including stronger luminous brightness and longer half-life compared with "traditional" self-luminescence platforms. As an emerging and booming hotspot, the "enhanced" self-luminescence facilitated by the win-win cooperation of the aggregation-induced emission and self-luminescent techniques has become a powerful tool for interdisciplinary research. This tutorial review summarizes the advancements of AIE-assisted self-luminescence including chemiluminescence and afterglow imaging, starting from the discussion on the design and working principles, luminescent mechanisms of self-luminescence fuels, versatile integrated approaches and advantages, and a broad range of representative examples in biosensors and oncotherapy. Finally, the current challenges and perspectives are discussed to further actuate the development of "enhanced" self-luminescence agents for biomedical diagnosis and treatment. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) This work was partially supported by the National Natural Science Foundation of China Grant (21788102), the Research Grants Council of Hong Kong (16305518, 16307020, C6014- 20W, C6009-17G and 16305618), the Innovation and Technology Commission (ITC-CNERC14SC01), and the Material Science Foundation of Guangdong Province (2019B121205012); J. F. thanks National Science Foundation of China 21925802, 21878039; K. P. thanks Singapore Ministry of Education, Academic Research Fund Tier 1 (2019-T1-002-045, RG125/19, RT05/ 20), Academic Research Fund Tier 2 (MOE2018-T2-2-042), and A*STAR SERC AME Programmatic Fund (SERC A18A8b0059) for the financial support. 2023-01-27T07:48:44Z 2023-01-27T07:48:44Z 2022 Journal Article Yang, M., Zeng, Z., Lam, J. W. Y., Fan, J., Pu, K. & Tang, B. Z. (2022). State-of-the-art self-luminescence: a win-win situation. Chemical Society Reviews, 51(21), 8815-8831. https://dx.doi.org/10.1039/d2cs00228k 0306-0012 https://hdl.handle.net/10356/164471 10.1039/d2cs00228k 36255029 2-s2.0-85141004642 21 51 8815 8831 en Chemical Society reviews © 2022 The Royal Society of Chemistry. All rights reserved. |
| spellingShingle | Engineering::Bioengineering Biosensing Techniques Luminescence Yang, Mingwang Zeng, Ziling Lam, Jacky W. Y. Fan, Jiangli Pu, Kanyi Tang, Ben Zhong State-of-the-art self-luminescence: a win-win situation |
| title | State-of-the-art self-luminescence: a win-win situation |
| title_full | State-of-the-art self-luminescence: a win-win situation |
| title_fullStr | State-of-the-art self-luminescence: a win-win situation |
| title_full_unstemmed | State-of-the-art self-luminescence: a win-win situation |
| title_short | State-of-the-art self-luminescence: a win-win situation |
| title_sort | state of the art self luminescence a win win situation |
| topic | Engineering::Bioengineering Biosensing Techniques Luminescence |
| url | https://hdl.handle.net/10356/164471 |
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