Experimental characterization of diffuse speckle pulsatile flowmetry system
The recently developed Diffuse Speckle Pulsatile Flowmetry (DSPF) technique offers high measurement rates of around 300 Hz for non-invasive blood flow measurement of blood flow in deep tissue (up to a depth of approximately 15 mm), showing promising potential for the monitoring of various pathologie...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://hdl.handle.net/10356/164521 |
| _version_ | 1811677852293136384 |
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| author | Choo, Tristan Wen Jie Zhang, Ruochong Bi, Renzhe Olivo, Malini |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Choo, Tristan Wen Jie Zhang, Ruochong Bi, Renzhe Olivo, Malini |
| author_sort | Choo, Tristan Wen Jie |
| collection | NTU |
| description | The recently developed Diffuse Speckle Pulsatile Flowmetry (DSPF) technique offers high measurement rates of around 300 Hz for non-invasive blood flow measurement of blood flow in deep tissue (up to a depth of approximately 15 mm), showing promising potential for the monitoring of various pathologies associated with abnormal blood flow. The effects of various parameters associated with this technique such as speckle size and exposure time on the measured flow readings, however, have yet to be studied. In this work, we examine these relationships experimentally, observing that the number of pixels per speckle (a measure of speckle size) and exposure time have a strong inverse relationship and a positive relationship respectively with the measured DSPF readings in no-flow setups using both static single light scattering and multiple light scattering mediums. We also studied how the sensitivity of DSPF readings to flow is affected by these parameters, finding that the number of pixels per speckle and exposure time have an inverse relationship and strong positive linear relationship respectively with the gradient of the regression line between the actual and measured flow rates in a dynamic setup using a tissue-mimicking flow phantom. It is hoped that these results would enable researchers using the DSPF technique to select and utilize the most optimized settings for their specific use applications. |
| first_indexed | 2024-10-01T02:43:57Z |
| format | Journal Article |
| id | ntu-10356/164521 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:43:57Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1645212023-12-29T06:45:38Z Experimental characterization of diffuse speckle pulsatile flowmetry system Choo, Tristan Wen Jie Zhang, Ruochong Bi, Renzhe Olivo, Malini School of Chemical and Biomedical Engineering Engineering::Bioengineering Laser Speckle Speckle Size The recently developed Diffuse Speckle Pulsatile Flowmetry (DSPF) technique offers high measurement rates of around 300 Hz for non-invasive blood flow measurement of blood flow in deep tissue (up to a depth of approximately 15 mm), showing promising potential for the monitoring of various pathologies associated with abnormal blood flow. The effects of various parameters associated with this technique such as speckle size and exposure time on the measured flow readings, however, have yet to be studied. In this work, we examine these relationships experimentally, observing that the number of pixels per speckle (a measure of speckle size) and exposure time have a strong inverse relationship and a positive relationship respectively with the measured DSPF readings in no-flow setups using both static single light scattering and multiple light scattering mediums. We also studied how the sensitivity of DSPF readings to flow is affected by these parameters, finding that the number of pixels per speckle and exposure time have an inverse relationship and strong positive linear relationship respectively with the gradient of the regression line between the actual and measured flow rates in a dynamic setup using a tissue-mimicking flow phantom. It is hoped that these results would enable researchers using the DSPF technique to select and utilize the most optimized settings for their specific use applications. Agency for Science, Technology and Research (A*STAR) Published version This research was funded by Agency of Science, Technology and Research (A*STAR) under its Industry Alignment Fund prepositioning program (IAF-PP), Award H19/01/a0/0EE9 and BMRC Central Research Fund (UIBR) 2021. 2023-01-30T07:50:38Z 2023-01-30T07:50:38Z 2022 Journal Article Choo, T. W. J., Zhang, R., Bi, R. & Olivo, M. (2022). Experimental characterization of diffuse speckle pulsatile flowmetry system. Frontiers in Physics, 10, 1006484-. https://dx.doi.org/10.3389/fphy.2022.1006484 2296-424X https://hdl.handle.net/10356/164521 10.3389/fphy.2022.1006484 2-s2.0-85139569771 10 1006484 en H19/01/a0/0EE9 (UIBR) 2021 Frontiers in Physics © 2022 Choo, Zhang, Bi and Olivo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf |
| spellingShingle | Engineering::Bioengineering Laser Speckle Speckle Size Choo, Tristan Wen Jie Zhang, Ruochong Bi, Renzhe Olivo, Malini Experimental characterization of diffuse speckle pulsatile flowmetry system |
| title | Experimental characterization of diffuse speckle pulsatile flowmetry system |
| title_full | Experimental characterization of diffuse speckle pulsatile flowmetry system |
| title_fullStr | Experimental characterization of diffuse speckle pulsatile flowmetry system |
| title_full_unstemmed | Experimental characterization of diffuse speckle pulsatile flowmetry system |
| title_short | Experimental characterization of diffuse speckle pulsatile flowmetry system |
| title_sort | experimental characterization of diffuse speckle pulsatile flowmetry system |
| topic | Engineering::Bioengineering Laser Speckle Speckle Size |
| url | https://hdl.handle.net/10356/164521 |
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