Erythrocyte tropism of malarial parasites: the reticulocyte appeal
Erythrocytes are formed from the enucleation of erythroblasts in the bone marrow, and as erythrocytes develop from immature reticulocytes into mature normocytes, they undergo extensive cellular changes through their passage in the blood. During the blood stage of the malarial parasite life cycle, th...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2023
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| Online Access: | https://hdl.handle.net/10356/164540 |
| _version_ | 1826125263459581952 |
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| author | Leong, Yew Wai Russell, Bruce Malleret, Benoit Rénia, Laurent |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Leong, Yew Wai Russell, Bruce Malleret, Benoit Rénia, Laurent |
| author_sort | Leong, Yew Wai |
| collection | NTU |
| description | Erythrocytes are formed from the enucleation of erythroblasts in the bone marrow, and as erythrocytes develop from immature reticulocytes into mature normocytes, they undergo extensive cellular changes through their passage in the blood. During the blood stage of the malarial parasite life cycle, the parasite sense and invade susceptible erythrocytes. However, different parasite species display varying erythrocyte tropisms (i.e., preference for either reticulocytes or normocytes). In this review, we explore the erythrocyte tropism of malarial parasites, especially their predilection to invade reticulocytes, as shown from recent studies. We also discuss possible mechanisms mediating erythrocyte tropism and the implications of specific tropisms to disease pathophysiology. Understanding these allows better insight into the role of reticulocytes in malaria and provides opportunities for targeted interventions. |
| first_indexed | 2024-10-01T06:33:48Z |
| format | Journal Article |
| id | ntu-10356/164540 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:33:48Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1645402023-02-28T17:13:39Z Erythrocyte tropism of malarial parasites: the reticulocyte appeal Leong, Yew Wai Russell, Bruce Malleret, Benoit Rénia, Laurent Lee Kong Chian School of Medicine (LKCMedicine) School of Biological Sciences A*STAR Infectious Diseases Labs Science::Biological sciences Science::Medicine Reticulocyte Normocyte Erythrocytes are formed from the enucleation of erythroblasts in the bone marrow, and as erythrocytes develop from immature reticulocytes into mature normocytes, they undergo extensive cellular changes through their passage in the blood. During the blood stage of the malarial parasite life cycle, the parasite sense and invade susceptible erythrocytes. However, different parasite species display varying erythrocyte tropisms (i.e., preference for either reticulocytes or normocytes). In this review, we explore the erythrocyte tropism of malarial parasites, especially their predilection to invade reticulocytes, as shown from recent studies. We also discuss possible mechanisms mediating erythrocyte tropism and the implications of specific tropisms to disease pathophysiology. Understanding these allows better insight into the role of reticulocytes in malaria and provides opportunities for targeted interventions. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) National Medical Research Council (NMRC) Published version LR is funded by the Singapore National Medical Research Council IRG Grant (NMRC/OFIRG/0065/2018), core grant given to A*STAR ID Labs by A*STAR, and by the Singapore Ministry of Education (Start-up University grant #022388-0001). 2023-01-31T06:46:00Z 2023-01-31T06:46:00Z 2022 Journal Article Leong, Y. W., Russell, B., Malleret, B. & Rénia, L. (2022). Erythrocyte tropism of malarial parasites: the reticulocyte appeal. Frontiers in Microbiology, 13, 1022828-. https://dx.doi.org/10.3389/fmicb.2022.1022828 1664-302X https://hdl.handle.net/10356/164540 10.3389/fmicb.2022.1022828 36386653 2-s2.0-85141567047 13 1022828 en NMRC/OFIRG/0065/2018 #022388-0001 Frontiers in Microbiology © 2022 Leong, Russell, Malleret and Rénia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf |
| spellingShingle | Science::Biological sciences Science::Medicine Reticulocyte Normocyte Leong, Yew Wai Russell, Bruce Malleret, Benoit Rénia, Laurent Erythrocyte tropism of malarial parasites: the reticulocyte appeal |
| title | Erythrocyte tropism of malarial parasites: the reticulocyte appeal |
| title_full | Erythrocyte tropism of malarial parasites: the reticulocyte appeal |
| title_fullStr | Erythrocyte tropism of malarial parasites: the reticulocyte appeal |
| title_full_unstemmed | Erythrocyte tropism of malarial parasites: the reticulocyte appeal |
| title_short | Erythrocyte tropism of malarial parasites: the reticulocyte appeal |
| title_sort | erythrocyte tropism of malarial parasites the reticulocyte appeal |
| topic | Science::Biological sciences Science::Medicine Reticulocyte Normocyte |
| url | https://hdl.handle.net/10356/164540 |
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