Three-dimensional printing technologies for drug delivery applications: processes, materials, and effects
Since the 1930s, new methods of drug delivery, such as implantable devices with drug release control, have been developed. However, manufacturing techniques require bulk due to high initial production costs. Three-dimensional (3D) printing, also known as additive manufacturing or rapid prototyping,...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/164640 |
| _version_ | 1811678076097003520 |
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| author | Mancilla-De-la-Cruz, Jessica Rodriguez-Salvador, Marisela An, Jia Chua, Chee Kai |
| author2 | Singapore Centre for 3D Printing |
| author_facet | Singapore Centre for 3D Printing Mancilla-De-la-Cruz, Jessica Rodriguez-Salvador, Marisela An, Jia Chua, Chee Kai |
| author_sort | Mancilla-De-la-Cruz, Jessica |
| collection | NTU |
| description | Since the 1930s, new methods of drug delivery, such as implantable devices with drug release control, have been developed. However, manufacturing techniques require bulk due to high initial production costs. Three-dimensional (3D) printing, also known as additive manufacturing or rapid prototyping, allows the fabrication of personalized drug delivery that uses different materials and complex geometries with multiple release profiles, thereby eradicating high initial costs. Different studies have been developed showing the extensive potential of 3D printing for the pharmaceutical industry, and despite in-depth discussions that have been published, there is no comprehensive review of processes, materials, and effects in drug delivery applications thus far. This review aims to fill this gap by presenting the use of 3D printing technology for drug delivery, exposing the different variations of the technique according to the characteristics, material, and dosage form sought. There are seven main categories of 3D printing according to the standards jointly developed by International Organization for Standardization and American Society for Testing and Materials: material jetting, binder jetting, material extrusion, vat photopolymerization, powder bed fusion, sheet lamination, and directed energy deposition. There are different 3D fabrication processes used for drug delivery applications depending on the dosage form and material applied. In this context, polymers, glasses, and hydrogels represent the most frequent materials used. 3D printing allows different forms of drug dosage. Oral, topical, rectal and vaginal, parental and implantable are discussed in this paper, presenting the identification of the type of 3D printing technology, the active pharmaceutical ingredient, formulation, and pharmaceutical effect. The main aim of this paper is to offer insights to people from academy and industry who are interested in the advancement of drug delivery and in knowing the future directions in the development of 3D printing applications in this area. |
| first_indexed | 2024-10-01T02:47:30Z |
| format | Journal Article |
| id | ntu-10356/164640 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:47:30Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1646402023-02-11T23:33:30Z Three-dimensional printing technologies for drug delivery applications: processes, materials, and effects Mancilla-De-la-Cruz, Jessica Rodriguez-Salvador, Marisela An, Jia Chua, Chee Kai Singapore Centre for 3D Printing Engineering::Mechanical engineering Three-Dimensional Printing Drug Delivery Since the 1930s, new methods of drug delivery, such as implantable devices with drug release control, have been developed. However, manufacturing techniques require bulk due to high initial production costs. Three-dimensional (3D) printing, also known as additive manufacturing or rapid prototyping, allows the fabrication of personalized drug delivery that uses different materials and complex geometries with multiple release profiles, thereby eradicating high initial costs. Different studies have been developed showing the extensive potential of 3D printing for the pharmaceutical industry, and despite in-depth discussions that have been published, there is no comprehensive review of processes, materials, and effects in drug delivery applications thus far. This review aims to fill this gap by presenting the use of 3D printing technology for drug delivery, exposing the different variations of the technique according to the characteristics, material, and dosage form sought. There are seven main categories of 3D printing according to the standards jointly developed by International Organization for Standardization and American Society for Testing and Materials: material jetting, binder jetting, material extrusion, vat photopolymerization, powder bed fusion, sheet lamination, and directed energy deposition. There are different 3D fabrication processes used for drug delivery applications depending on the dosage form and material applied. In this context, polymers, glasses, and hydrogels represent the most frequent materials used. 3D printing allows different forms of drug dosage. Oral, topical, rectal and vaginal, parental and implantable are discussed in this paper, presenting the identification of the type of 3D printing technology, the active pharmaceutical ingredient, formulation, and pharmaceutical effect. The main aim of this paper is to offer insights to people from academy and industry who are interested in the advancement of drug delivery and in knowing the future directions in the development of 3D printing applications in this area. Published version The authors acknowledge institutional funding received from Tecnologico de Monterrey and Consejo Nacional de Ciencia y Tecnología (CONACyT) through a Graduate Studies Scholarship and an Academic Scholarship as member of the National System of Researchers (Sistema Nacional de Investigadores). 2023-02-07T02:58:45Z 2023-02-07T02:58:45Z 2022 Journal Article Mancilla-De-la-Cruz, J., Rodriguez-Salvador, M., An, J. & Chua, C. K. (2022). Three-dimensional printing technologies for drug delivery applications: processes, materials, and effects. International Journal of Bioprinting, 8(4), 321-346. https://dx.doi.org/10.18063/ijb.v8i4.622 2424-7723 https://hdl.handle.net/10356/164640 10.18063/ijb.v8i4.622 36404786 2-s2.0-85141793846 4 8 321 346 en International Journal of Bioprinting © 2022 Author(s). This is an Open-Access article distributed under the terms of the Creative Commons Attribution License, permitting distribution and reproduction in any medium, provided the original work is properly cited. application/pdf |
| spellingShingle | Engineering::Mechanical engineering Three-Dimensional Printing Drug Delivery Mancilla-De-la-Cruz, Jessica Rodriguez-Salvador, Marisela An, Jia Chua, Chee Kai Three-dimensional printing technologies for drug delivery applications: processes, materials, and effects |
| title | Three-dimensional printing technologies for drug delivery applications: processes, materials, and effects |
| title_full | Three-dimensional printing technologies for drug delivery applications: processes, materials, and effects |
| title_fullStr | Three-dimensional printing technologies for drug delivery applications: processes, materials, and effects |
| title_full_unstemmed | Three-dimensional printing technologies for drug delivery applications: processes, materials, and effects |
| title_short | Three-dimensional printing technologies for drug delivery applications: processes, materials, and effects |
| title_sort | three dimensional printing technologies for drug delivery applications processes materials and effects |
| topic | Engineering::Mechanical engineering Three-Dimensional Printing Drug Delivery |
| url | https://hdl.handle.net/10356/164640 |
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