Hydrogel on a smart nanomaterial interface to carry therapeutics for digitalized glioma treatment
Glioma is considered the primary brain tumor to cause brain illnesses, and it is difficult to treat and shows resistance to various routine therapeutics. The most common treatments to cure glioma are the surgical removal of tumors followed by adjuvant chemotherapy and radiation therapy. The latest b...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Language: | English |
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2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/164722 |
| _version_ | 1811676895151915008 |
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| author | Zhao, Xinyi Javed, Bilal Tian, Furong Liu, Kangze |
| author2 | School of Chemistry, Chemical Engineering and Biotechnology |
| author_facet | School of Chemistry, Chemical Engineering and Biotechnology Zhao, Xinyi Javed, Bilal Tian, Furong Liu, Kangze |
| author_sort | Zhao, Xinyi |
| collection | NTU |
| description | Glioma is considered the primary brain tumor to cause brain illnesses, and it is difficult to treat and shows resistance to various routine therapeutics. The most common treatments to cure glioma are the surgical removal of tumors followed by adjuvant chemotherapy and radiation therapy. The latest biocompatible interfaces have been incorporated into therapeutic modalities such as the targeted delivery of drugs using hydrogels to treat and manage brain glioma. This review illustrates the applications of the multimodal hydrogel as the carrier of therapeutics, gene therapy, therapeutic tactics, and glioma devices. The scientific articles were retrieved from 2019 to 2022 on Google Scholar and the Scopus database and screened to determine whether they were suitable for review. The 20 articles that fit the study are summarized in this review. These studies indicated that the sizes of the hydrogel range from 28 nm to 500 nm. There are 16 out of 20 articles that also explain the post-surgical application of hydrogels, and 13 out of 20 articles are employed in 3D culture and other structural manifestations of hydrogels. The pros of the hydrogel include the quick formulation for a sufficient filling of irregular damage sites, solubilizing hydrophobic drugs, continuously slowing drug release, provision of a 3D cell growth environment, improving efficacy, targetability of soluble biomolecules, increasing patient compliance, and decreased side effects. The cons of the hydrogel include difficult real-time monitoring, genetic manipulations, the cumbersome synchronized release of components, and lack of safety data. The prospects of the hydrogel may include the development of electronic hydrogel sensors that can be used to enhance guidance for the precise targeting patterns using patient-specific pathological idiosyncrasies. This technology has the potential to revolutionize the precision medicine approaches that would aid in the early detection and management of solid brain tumors. |
| first_indexed | 2024-10-01T02:28:44Z |
| format | Journal Article |
| id | ntu-10356/164722 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:28:44Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1647222023-06-21T07:56:42Z Hydrogel on a smart nanomaterial interface to carry therapeutics for digitalized glioma treatment Zhao, Xinyi Javed, Bilal Tian, Furong Liu, Kangze School of Chemistry, Chemical Engineering and Biotechnology Engineering::Bioengineering Glioma Hydrogel Glioma is considered the primary brain tumor to cause brain illnesses, and it is difficult to treat and shows resistance to various routine therapeutics. The most common treatments to cure glioma are the surgical removal of tumors followed by adjuvant chemotherapy and radiation therapy. The latest biocompatible interfaces have been incorporated into therapeutic modalities such as the targeted delivery of drugs using hydrogels to treat and manage brain glioma. This review illustrates the applications of the multimodal hydrogel as the carrier of therapeutics, gene therapy, therapeutic tactics, and glioma devices. The scientific articles were retrieved from 2019 to 2022 on Google Scholar and the Scopus database and screened to determine whether they were suitable for review. The 20 articles that fit the study are summarized in this review. These studies indicated that the sizes of the hydrogel range from 28 nm to 500 nm. There are 16 out of 20 articles that also explain the post-surgical application of hydrogels, and 13 out of 20 articles are employed in 3D culture and other structural manifestations of hydrogels. The pros of the hydrogel include the quick formulation for a sufficient filling of irregular damage sites, solubilizing hydrophobic drugs, continuously slowing drug release, provision of a 3D cell growth environment, improving efficacy, targetability of soluble biomolecules, increasing patient compliance, and decreased side effects. The cons of the hydrogel include difficult real-time monitoring, genetic manipulations, the cumbersome synchronized release of components, and lack of safety data. The prospects of the hydrogel may include the development of electronic hydrogel sensors that can be used to enhance guidance for the precise targeting patterns using patient-specific pathological idiosyncrasies. This technology has the potential to revolutionize the precision medicine approaches that would aid in the early detection and management of solid brain tumors. Published version This research was funded by TU Dublin Postgraduate Research Scholarship Program and Enterprise Ireland for financial support. 2023-02-13T01:52:44Z 2023-02-13T01:52:44Z 2022 Journal Article Zhao, X., Javed, B., Tian, F. & Liu, K. (2022). Hydrogel on a smart nanomaterial interface to carry therapeutics for digitalized glioma treatment. Gels, 8(10), 8100664-. https://dx.doi.org/10.3390/gels8100664 2310-2861 https://hdl.handle.net/10356/164722 10.3390/gels8100664 36286164 2-s2.0-85140754006 10 8 8100664 en Gels © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). application/pdf |
| spellingShingle | Engineering::Bioengineering Glioma Hydrogel Zhao, Xinyi Javed, Bilal Tian, Furong Liu, Kangze Hydrogel on a smart nanomaterial interface to carry therapeutics for digitalized glioma treatment |
| title | Hydrogel on a smart nanomaterial interface to carry therapeutics for digitalized glioma treatment |
| title_full | Hydrogel on a smart nanomaterial interface to carry therapeutics for digitalized glioma treatment |
| title_fullStr | Hydrogel on a smart nanomaterial interface to carry therapeutics for digitalized glioma treatment |
| title_full_unstemmed | Hydrogel on a smart nanomaterial interface to carry therapeutics for digitalized glioma treatment |
| title_short | Hydrogel on a smart nanomaterial interface to carry therapeutics for digitalized glioma treatment |
| title_sort | hydrogel on a smart nanomaterial interface to carry therapeutics for digitalized glioma treatment |
| topic | Engineering::Bioengineering Glioma Hydrogel |
| url | https://hdl.handle.net/10356/164722 |
| work_keys_str_mv | AT zhaoxinyi hydrogelonasmartnanomaterialinterfacetocarrytherapeuticsfordigitalizedgliomatreatment AT javedbilal hydrogelonasmartnanomaterialinterfacetocarrytherapeuticsfordigitalizedgliomatreatment AT tianfurong hydrogelonasmartnanomaterialinterfacetocarrytherapeuticsfordigitalizedgliomatreatment AT liukangze hydrogelonasmartnanomaterialinterfacetocarrytherapeuticsfordigitalizedgliomatreatment |