Endoplasmic reticulum stress and lipids in health and diseases
The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many cellular pathways, including protein synthesis, protein quality control, and lipid synthesis. When one or multiple ER roles are dysregulated and saturated, the ER enters a stress state, which, in turn, activates th...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Language: | English |
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2023
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| Online Access: | https://hdl.handle.net/10356/164761 |
| _version_ | 1811676916235632640 |
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| author | Celik, Cenk Lee, Stella Yue Ting Yap, Wei Sheng Thibault, Guillaume |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Celik, Cenk Lee, Stella Yue Ting Yap, Wei Sheng Thibault, Guillaume |
| author_sort | Celik, Cenk |
| collection | NTU |
| description | The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many cellular pathways, including protein synthesis, protein quality control, and lipid synthesis. When one or multiple ER roles are dysregulated and saturated, the ER enters a stress state, which, in turn, activates the highly conserved unfolded protein response (UPR). By sensing the accumulation of unfolded proteins or lipid bilayer stress (LBS) at the ER, the UPR triggers pathways to restore ER homeostasis and eventually induces apoptosis if the stress remains unresolved. In recent years, it has emerged that the UPR works intimately with other cellular pathways to maintain lipid homeostasis at the ER, and so does at cellular levels. Lipid distribution, along with lipid anabolism and catabolism, are tightly regulated, in part, by the ER. Dysfunctional and overwhelmed lipid-related pathways, independently or in combination with ER stress, can have reciprocal effects on other cellular functions, contributing to the development of diseases. In this review, we summarize the current understanding of the UPR in response to proteotoxic stress and LBS and the breadth of the functions mitigated by the UPR in different tissues and in the context of diseases. |
| first_indexed | 2024-10-01T02:29:04Z |
| format | Journal Article |
| id | ntu-10356/164761 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:29:04Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1647612023-02-13T07:52:12Z Endoplasmic reticulum stress and lipids in health and diseases Celik, Cenk Lee, Stella Yue Ting Yap, Wei Sheng Thibault, Guillaume School of Biological Sciences Science::Biological sciences Cancer Diabetes The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many cellular pathways, including protein synthesis, protein quality control, and lipid synthesis. When one or multiple ER roles are dysregulated and saturated, the ER enters a stress state, which, in turn, activates the highly conserved unfolded protein response (UPR). By sensing the accumulation of unfolded proteins or lipid bilayer stress (LBS) at the ER, the UPR triggers pathways to restore ER homeostasis and eventually induces apoptosis if the stress remains unresolved. In recent years, it has emerged that the UPR works intimately with other cellular pathways to maintain lipid homeostasis at the ER, and so does at cellular levels. Lipid distribution, along with lipid anabolism and catabolism, are tightly regulated, in part, by the ER. Dysfunctional and overwhelmed lipid-related pathways, independently or in combination with ER stress, can have reciprocal effects on other cellular functions, contributing to the development of diseases. In this review, we summarize the current understanding of the UPR in response to proteotoxic stress and LBS and the breadth of the functions mitigated by the UPR in different tissues and in the context of diseases. Monetary Authority of Singapore National Medical Research Council (NMRC) National Research Foundation (NRF) This work was supported by funds from the National Medical Research Council Open Fund (MOH-000566), the National Research Foundation, Singapore, under its NRF-NSFC joint research grant call (NRF2018NRFNSFC003SB-006), and the NTU Research Scholarship to S.Y.T.L. (predoctoral fellowship). 2023-02-13T07:52:12Z 2023-02-13T07:52:12Z 2023 Journal Article Celik, C., Lee, S. Y. T., Yap, W. S. & Thibault, G. (2023). Endoplasmic reticulum stress and lipids in health and diseases. Progress in Lipid Research, 89, 101198-. https://dx.doi.org/10.1016/j.plipres.2022.101198 0163-7827 https://hdl.handle.net/10356/164761 10.1016/j.plipres.2022.101198 36379317 2-s2.0-85141968441 89 101198 en MOH-000566 NRF2018NRFNSFC003SB-006 Progress in Lipid Research © 2022 Elsevier Ltd. All rights reserved. |
| spellingShingle | Science::Biological sciences Cancer Diabetes Celik, Cenk Lee, Stella Yue Ting Yap, Wei Sheng Thibault, Guillaume Endoplasmic reticulum stress and lipids in health and diseases |
| title | Endoplasmic reticulum stress and lipids in health and diseases |
| title_full | Endoplasmic reticulum stress and lipids in health and diseases |
| title_fullStr | Endoplasmic reticulum stress and lipids in health and diseases |
| title_full_unstemmed | Endoplasmic reticulum stress and lipids in health and diseases |
| title_short | Endoplasmic reticulum stress and lipids in health and diseases |
| title_sort | endoplasmic reticulum stress and lipids in health and diseases |
| topic | Science::Biological sciences Cancer Diabetes |
| url | https://hdl.handle.net/10356/164761 |
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