The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression
Liver physiology is circadian and sensitive to feeding and insulin. Food intake regulates insulin secretion and is a dominant signal for the liver clock. However, how much insulin contributes to the effect of feeding on the liver clock and rhythmic gene expression remains to be investigated. Insulin...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/164881 |
| _version_ | 1826125637154242560 |
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| author | Fougeray, Tiffany Polizzi, Arnaud Régnier, Marion Fougerat, Anne Ellero-Simatos, Sandrine Lippi, Yannick Smati, Sarra Lasserre, Frédéric Tramunt, Blandine Huillet, Marine Dopavogui, Léonie Salvi, Juliette Nédélec, Emmanuelle Gigot, Vincent Smith, Lorraine Naylies, Claire Sommer, Caroline Haas, Joel T. Wahli, Walter Duez, Hélène Gourdy, Pierre Gamet-Payrastre, Laurence Benani, Alexandre Burnol, Anne-Françoise Loiseau, Nicolas Postic, Catherine Montagner, Alexandra Guillou, Hervé |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Fougeray, Tiffany Polizzi, Arnaud Régnier, Marion Fougerat, Anne Ellero-Simatos, Sandrine Lippi, Yannick Smati, Sarra Lasserre, Frédéric Tramunt, Blandine Huillet, Marine Dopavogui, Léonie Salvi, Juliette Nédélec, Emmanuelle Gigot, Vincent Smith, Lorraine Naylies, Claire Sommer, Caroline Haas, Joel T. Wahli, Walter Duez, Hélène Gourdy, Pierre Gamet-Payrastre, Laurence Benani, Alexandre Burnol, Anne-Françoise Loiseau, Nicolas Postic, Catherine Montagner, Alexandra Guillou, Hervé |
| author_sort | Fougeray, Tiffany |
| collection | NTU |
| description | Liver physiology is circadian and sensitive to feeding and insulin. Food intake regulates insulin secretion and is a dominant signal for the liver clock. However, how much insulin contributes to the effect of feeding on the liver clock and rhythmic gene expression remains to be investigated. Insulin action partly depends on changes in insulin receptor (IR)-dependent gene expression. Here, we use hepatocyte-restricted gene deletion of IR to evaluate its role in the regulation and oscillation of gene expression as well as in the programming of the circadian clock in the adult mouse liver. We find that, in the absence of IR, the rhythmicity of core-clock gene expression is altered in response to day-restricted feeding. This change in core-clock gene expression is associated with defective reprogramming of liver gene expression. Our data show that an intact hepatocyte insulin receptor is required to program the liver clock and associated rhythmic gene expression. |
| first_indexed | 2024-10-01T06:39:37Z |
| format | Journal Article |
| id | ntu-10356/164881 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:39:37Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1648812023-03-05T16:55:24Z The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression Fougeray, Tiffany Polizzi, Arnaud Régnier, Marion Fougerat, Anne Ellero-Simatos, Sandrine Lippi, Yannick Smati, Sarra Lasserre, Frédéric Tramunt, Blandine Huillet, Marine Dopavogui, Léonie Salvi, Juliette Nédélec, Emmanuelle Gigot, Vincent Smith, Lorraine Naylies, Claire Sommer, Caroline Haas, Joel T. Wahli, Walter Duez, Hélène Gourdy, Pierre Gamet-Payrastre, Laurence Benani, Alexandre Burnol, Anne-Françoise Loiseau, Nicolas Postic, Catherine Montagner, Alexandra Guillou, Hervé Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Insulin Receptor Circadian Liver physiology is circadian and sensitive to feeding and insulin. Food intake regulates insulin secretion and is a dominant signal for the liver clock. However, how much insulin contributes to the effect of feeding on the liver clock and rhythmic gene expression remains to be investigated. Insulin action partly depends on changes in insulin receptor (IR)-dependent gene expression. Here, we use hepatocyte-restricted gene deletion of IR to evaluate its role in the regulation and oscillation of gene expression as well as in the programming of the circadian clock in the adult mouse liver. We find that, in the absence of IR, the rhythmicity of core-clock gene expression is altered in response to day-restricted feeding. This change in core-clock gene expression is associated with defective reprogramming of liver gene expression. Our data show that an intact hepatocyte insulin receptor is required to program the liver clock and associated rhythmic gene expression. Published version T.F. was supported by a PhD grant from Toulouse University and by INRAE and Institut National du Cancer (INCA). A.F. was supported by an Agreenskills post-doctoral fellowship. B.T. was supported by FRM (FDM201906008682). A.B. was supported by ISITE-BFC (contract ANR-15-IDEX-0003). T.F., B.T., P.G., C.P., A.M., and H.G. were supported by grants from ‘‘Socie ́te ́ Francophone du Diabe‘te.’’ P.G., N.L., A.M., and H.G. were supported by grants from Re ́gion Occitanie. P.G., H.D., N.L., C.P., A.M., and H.G. were supported by a Hepatomorphic grant from ANR. 2023-02-22T01:16:23Z 2023-02-22T01:16:23Z 2022 Journal Article Fougeray, T., Polizzi, A., Régnier, M., Fougerat, A., Ellero-Simatos, S., Lippi, Y., Smati, S., Lasserre, F., Tramunt, B., Huillet, M., Dopavogui, L., Salvi, J., Nédélec, E., Gigot, V., Smith, L., Naylies, C., Sommer, C., Haas, J. T., Wahli, W., ...Guillou, H. (2022). The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression. Cell Reports, 39(2), 110674-. https://dx.doi.org/10.1016/j.celrep.2022.110674 2211-1247 https://hdl.handle.net/10356/164881 10.1016/j.celrep.2022.110674 35417722 2-s2.0-85128132344 2 39 110674 en Cell Reports © 2022 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). application/pdf |
| spellingShingle | Science::Medicine Insulin Receptor Circadian Fougeray, Tiffany Polizzi, Arnaud Régnier, Marion Fougerat, Anne Ellero-Simatos, Sandrine Lippi, Yannick Smati, Sarra Lasserre, Frédéric Tramunt, Blandine Huillet, Marine Dopavogui, Léonie Salvi, Juliette Nédélec, Emmanuelle Gigot, Vincent Smith, Lorraine Naylies, Claire Sommer, Caroline Haas, Joel T. Wahli, Walter Duez, Hélène Gourdy, Pierre Gamet-Payrastre, Laurence Benani, Alexandre Burnol, Anne-Françoise Loiseau, Nicolas Postic, Catherine Montagner, Alexandra Guillou, Hervé The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression |
| title | The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression |
| title_full | The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression |
| title_fullStr | The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression |
| title_full_unstemmed | The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression |
| title_short | The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression |
| title_sort | hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression |
| topic | Science::Medicine Insulin Receptor Circadian |
| url | https://hdl.handle.net/10356/164881 |
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