Brown adipose tissue influences adiponectin and thyroid hormone changes during Graves' disease therapy
Thyroid hormones (TH), adiponectin and brown adipose tissue (BAT) are regulators of energy homoeostasis. Influence of BAT activity on the relationship between TH and adiponectin remains unexplored. The aim of the study was to identify the relationship between TH and adiponectin and to clarify the im...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://hdl.handle.net/10356/165026 |
| _version_ | 1811693624697552896 |
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| author | Ho, Wei-En Sun, Lijuan Goh, Hui Jen Tint, Mya Thway Sun, Lei Leow, Melvin Khee Shing |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Ho, Wei-En Sun, Lijuan Goh, Hui Jen Tint, Mya Thway Sun, Lei Leow, Melvin Khee Shing |
| author_sort | Ho, Wei-En |
| collection | NTU |
| description | Thyroid hormones (TH), adiponectin and brown adipose tissue (BAT) are regulators of energy homoeostasis. Influence of BAT activity on the relationship between TH and adiponectin remains unexplored. The aim of the study was to identify the relationship between TH and adiponectin and to clarify the impact of active BAT on the metabolic effects of adiponectin before and after the correction of thyrotoxicosis. Twenty-one patients with newly diagnosed hyperthyroidism from Graves' disease were recruited. A titration dosing regimen of thionamide anti-thyroid drug (ATD) was used to establish euthyroidism over 12-24 weeks. Anthropometric, biochemical and adipocytokine parameters were measured before and after control of hyperthyroidism. BAT activity was quantified by fusion 18 F-fluorodeoxyglucose (18 F-FDG) PET/MR imaging, and patients were grouped based on BAT status. Plasma adiponectin level was significantly increased following correction of hyperthyroidism in the overall sample. Free thyroxine (FT4) was also identified as a predictor of adiponectin level in thyroid dysfunction. However, significant changes in adiponectin level and correlations involving adiponectin were absent in BAT-positive patients but maintained in BAT-negative patients. BAT activity diminishes the correlative relationship with body composition and abolishes TH and adiponectin relationships when transitioning from a hyperthyroid to euthyroid state. |
| first_indexed | 2024-10-01T06:54:39Z |
| format | Journal Article |
| id | ntu-10356/165026 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:54:39Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1650262023-03-12T15:42:28Z Brown adipose tissue influences adiponectin and thyroid hormone changes during Graves' disease therapy Ho, Wei-En Sun, Lijuan Goh, Hui Jen Tint, Mya Thway Sun, Lei Leow, Melvin Khee Shing Lee Kong Chian School of Medicine (LKCMedicine) Singapore Institute for Clinical Sciences, A*STAR Yong Loo Lin School of Medicine, NUS Tan Tock Seng Hospital Science::Medicine Hyperthyroidism Adiponectin Thyroid hormones (TH), adiponectin and brown adipose tissue (BAT) are regulators of energy homoeostasis. Influence of BAT activity on the relationship between TH and adiponectin remains unexplored. The aim of the study was to identify the relationship between TH and adiponectin and to clarify the impact of active BAT on the metabolic effects of adiponectin before and after the correction of thyrotoxicosis. Twenty-one patients with newly diagnosed hyperthyroidism from Graves' disease were recruited. A titration dosing regimen of thionamide anti-thyroid drug (ATD) was used to establish euthyroidism over 12-24 weeks. Anthropometric, biochemical and adipocytokine parameters were measured before and after control of hyperthyroidism. BAT activity was quantified by fusion 18 F-fluorodeoxyglucose (18 F-FDG) PET/MR imaging, and patients were grouped based on BAT status. Plasma adiponectin level was significantly increased following correction of hyperthyroidism in the overall sample. Free thyroxine (FT4) was also identified as a predictor of adiponectin level in thyroid dysfunction. However, significant changes in adiponectin level and correlations involving adiponectin were absent in BAT-positive patients but maintained in BAT-negative patients. BAT activity diminishes the correlative relationship with body composition and abolishes TH and adiponectin relationships when transitioning from a hyperthyroid to euthyroid state. Agency for Science, Technology and Research (A*STAR) Published version The study was supported by the Singapore Ministry of Health’s National Medical Research Council (NMRC) Clinician Scientist Award. (grant ID NMRC/CSA-INV /0003/2015) and the Agency for Science, Technology and Research (A *STAR) awarded to A/Prof. Melvin Leow. 2023-03-08T03:04:22Z 2023-03-08T03:04:22Z 2022 Journal Article Ho, W., Sun, L., Goh, H. J., Tint, M. T., Sun, L. & Leow, M. K. S. (2022). Brown adipose tissue influences adiponectin and thyroid hormone changes during Graves' disease therapy. Adipocyte, 11(1), 389-400. https://dx.doi.org/10.1080/21623945.2022.2104509 2162-3945 https://hdl.handle.net/10356/165026 10.1080/21623945.2022.2104509 35894647 2-s2.0-85135144485 1 11 389 400 en NMRC/CSA-INV /0003/2015 Adipocyte © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. application/pdf |
| spellingShingle | Science::Medicine Hyperthyroidism Adiponectin Ho, Wei-En Sun, Lijuan Goh, Hui Jen Tint, Mya Thway Sun, Lei Leow, Melvin Khee Shing Brown adipose tissue influences adiponectin and thyroid hormone changes during Graves' disease therapy |
| title | Brown adipose tissue influences adiponectin and thyroid hormone changes during Graves' disease therapy |
| title_full | Brown adipose tissue influences adiponectin and thyroid hormone changes during Graves' disease therapy |
| title_fullStr | Brown adipose tissue influences adiponectin and thyroid hormone changes during Graves' disease therapy |
| title_full_unstemmed | Brown adipose tissue influences adiponectin and thyroid hormone changes during Graves' disease therapy |
| title_short | Brown adipose tissue influences adiponectin and thyroid hormone changes during Graves' disease therapy |
| title_sort | brown adipose tissue influences adiponectin and thyroid hormone changes during graves disease therapy |
| topic | Science::Medicine Hyperthyroidism Adiponectin |
| url | https://hdl.handle.net/10356/165026 |
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