The associations between poor antibiotic and antimicrobial resistance knowledge and inappropriate antibiotic use in the general population are modified by age
Objectives: Understanding factors influencing inappropriate antibiotic use can guide the design of interventions to improve antibiotic practices and reduce antimicrobial resistance (AMR). Methods: A nationally representative cross-sectional survey (N = 2004) was conducted between November 2020 and J...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Language: | English |
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2023
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| Online Access: | https://hdl.handle.net/10356/165132 |
| _version_ | 1826116639143231488 |
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| author | Guo, Huiling Hildon, Zoe Jane-Lara Lye, David C. Straughan, Paulin Tay Chow, Angela |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Guo, Huiling Hildon, Zoe Jane-Lara Lye, David C. Straughan, Paulin Tay Chow, Angela |
| author_sort | Guo, Huiling |
| collection | NTU |
| description | Objectives: Understanding factors influencing inappropriate antibiotic use can guide the design of interventions to improve antibiotic practices and reduce antimicrobial resistance (AMR). Methods: A nationally representative cross-sectional survey (N = 2004) was conducted between November 2020 and January 2021. Knowledge of antibiotic use and AMR using the World Health Organization’s Multi-Country AMR Survey questionnaire, and antibiotic practices were examined. Multivariable logistic regression was performed to identify factors associated with inappropriate antibiotic use and examine effect measure modifications. Results: After adjusting for potential con-founding, poor knowledge of antibiotic use was associated with a 3x increased odds of inappropriate antibiotic use in adults aged ≥50 years (aOR 3.11, 95% CI [2.24–4.32]), 5× increased odds in those aged 35–49 years (aOR 4.88, 95% CI [3.32–7.16]), and 7× increased odds in those aged 21–34 years (aOR 6.58, 95% CI [4.19–10.33]). While there was no statistically significant association in adults aged ≥50 years, poor knowledge of AMR increased the odds of inappropriate antibiotic use by 4 times in adults aged 35–49 years (aOR 3.73, 95% CI [1.53–9.11]) and 5 times in those aged 21–34 years (aOR 4.90, 95% CI [1.84–13.02]). Conclusions: Targeted educational interventions for specific age groups are needed in conjunction with empowering the public with knowledge of antibiotic use and AMR. |
| first_indexed | 2024-10-01T04:14:40Z |
| format | Journal Article |
| id | ntu-10356/165132 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:14:40Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1651322023-03-19T15:37:20Z The associations between poor antibiotic and antimicrobial resistance knowledge and inappropriate antibiotic use in the general population are modified by age Guo, Huiling Hildon, Zoe Jane-Lara Lye, David C. Straughan, Paulin Tay Chow, Angela Lee Kong Chian School of Medicine (LKCMedicine) National Centre for Infectious Diseases, Singapore Yong Loo Lin School of Medicine, NUS Tan Tock Seng Hospital Science::Medicine Antimicrobial Resistance Public Knowledge Objectives: Understanding factors influencing inappropriate antibiotic use can guide the design of interventions to improve antibiotic practices and reduce antimicrobial resistance (AMR). Methods: A nationally representative cross-sectional survey (N = 2004) was conducted between November 2020 and January 2021. Knowledge of antibiotic use and AMR using the World Health Organization’s Multi-Country AMR Survey questionnaire, and antibiotic practices were examined. Multivariable logistic regression was performed to identify factors associated with inappropriate antibiotic use and examine effect measure modifications. Results: After adjusting for potential con-founding, poor knowledge of antibiotic use was associated with a 3x increased odds of inappropriate antibiotic use in adults aged ≥50 years (aOR 3.11, 95% CI [2.24–4.32]), 5× increased odds in those aged 35–49 years (aOR 4.88, 95% CI [3.32–7.16]), and 7× increased odds in those aged 21–34 years (aOR 6.58, 95% CI [4.19–10.33]). While there was no statistically significant association in adults aged ≥50 years, poor knowledge of AMR increased the odds of inappropriate antibiotic use by 4 times in adults aged 35–49 years (aOR 3.73, 95% CI [1.53–9.11]) and 5 times in those aged 21–34 years (aOR 4.90, 95% CI [1.84–13.02]). Conclusions: Targeted educational interventions for specific age groups are needed in conjunction with empowering the public with knowledge of antibiotic use and AMR. National Medical Research Council (NMRC) Published version This research was funded by the National Medical Research Council Singapore, Health Services Research Grant (NMRC/HSRG/0083/2017). 2023-03-14T07:32:07Z 2023-03-14T07:32:07Z 2022 Journal Article Guo, H., Hildon, Z. J., Lye, D. C. B., Straughan, P. T. & Chow, A. (2022). The associations between poor antibiotic and antimicrobial resistance knowledge and inappropriate antibiotic use in the general population are modified by age. Antibiotics, 11(1), 11010047-. https://dx.doi.org/10.3390/antibiotics11010047 2079-6382 https://hdl.handle.net/10356/165132 10.3390/antibiotics11010047 35052924 2-s2.0-85122229102 1 11 11010047 en NMRC/HSRG/0083/2017 Antibiotics © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). application/pdf |
| spellingShingle | Science::Medicine Antimicrobial Resistance Public Knowledge Guo, Huiling Hildon, Zoe Jane-Lara Lye, David C. Straughan, Paulin Tay Chow, Angela The associations between poor antibiotic and antimicrobial resistance knowledge and inappropriate antibiotic use in the general population are modified by age |
| title | The associations between poor antibiotic and antimicrobial resistance knowledge and inappropriate antibiotic use in the general population are modified by age |
| title_full | The associations between poor antibiotic and antimicrobial resistance knowledge and inappropriate antibiotic use in the general population are modified by age |
| title_fullStr | The associations between poor antibiotic and antimicrobial resistance knowledge and inappropriate antibiotic use in the general population are modified by age |
| title_full_unstemmed | The associations between poor antibiotic and antimicrobial resistance knowledge and inappropriate antibiotic use in the general population are modified by age |
| title_short | The associations between poor antibiotic and antimicrobial resistance knowledge and inappropriate antibiotic use in the general population are modified by age |
| title_sort | associations between poor antibiotic and antimicrobial resistance knowledge and inappropriate antibiotic use in the general population are modified by age |
| topic | Science::Medicine Antimicrobial Resistance Public Knowledge |
| url | https://hdl.handle.net/10356/165132 |
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