Adipose-specific PPARα knockout mice have increased lipogenesis by PASK-SREBP1 signaling and a polarity shift to inflammatory macrophages in white adipose tissue

Adipose-specific PPARα knockout mice have increased lipogenesis by PASK-SREBP1 signaling and a polarity shift to inflammatory macrophages in white adipose tissue

The nuclear receptor PPARα is associated with reducing adiposity, especially in the liver, where it transactivates genes for β-oxidation. Contrarily, the function of PPARα in extrahepatic tissues is less known. Therefore, we established the first adipose-specific PPARα knockout (PparaFatKO) mice to...

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Bibliographic Details
Main Authors: Hinds, Terry D., Kipp, Zachary A., Xu, Mei, Yiannikouris, Frederique B., Morris, Andrew J., Stec, Donald F., Wahli, Walter, Stec, David E.
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2023
Subjects:
Science::Medicine
Obesity
Cholesterol Esters
Online Access:https://hdl.handle.net/10356/165261

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