Designing biofunctional scaffolds by additive manufacturing for nerve regeneration

This study explores the use of gelatin as a biomaterial for 3D printing of neural scaffolds, with a focus on optimizing scaffold properties and functionality. The project utilizes a pneumatic extrusion 3D printer, with additional investigations into dual extrusion with Pluronic F127, various process...

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Bibliographic Details
Main Author: Ng, Titan Yong Qiang
Other Authors: Chew Sing Yian
Format: Final Year Project (FYP)
Language:English
Published: Nanyang Technological University 2023
Subjects:
Online Access:https://hdl.handle.net/10356/165662
Description
Summary:This study explores the use of gelatin as a biomaterial for 3D printing of neural scaffolds, with a focus on optimizing scaffold properties and functionality. The project utilizes a pneumatic extrusion 3D printer, with additional investigations into dual extrusion with Pluronic F127, various processing methods of gelatin, line width characterization, and rheology studies. Gelatin is a promising material for tissue engineering applications due to its biocompatibility, biodegradability, and low immunogenicity. The results of this study demonstrate the potential of 3D printing with gelatin for creating complex, functionalized scaffolds with improved mechanical and biological properties, especially for low-pressure printing for potential cell-laden printing. The findings provide insight into the optimal processing methods and printing parameters for achieving desired scaffold properties.