Identification of biomarker in patients on low dose warfarin : an iTRAQ-coupled LC-MS/MS approach
Warfarin is one of the most widely used oral anticoagulant. However, the dosage of warfarin given to patients is very critical as an overdose may lead to severe bleeding or an under-dosing may lead to clotting of the blood. Hence, it is important to find clues and leads to enable medical professiona...
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| Format: | Final Year Project (FYP) |
| Language: | English |
| Published: |
2009
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| Online Access: | http://hdl.handle.net/10356/16589 |
| _version_ | 1826113829269929984 |
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| author | Koh, Regina Hwee Chen. |
| author2 | Chen Wei Ning, William |
| author_facet | Chen Wei Ning, William Koh, Regina Hwee Chen. |
| author_sort | Koh, Regina Hwee Chen. |
| collection | NTU |
| description | Warfarin is one of the most widely used oral anticoagulant. However, the dosage of warfarin given to patients is very critical as an overdose may lead to severe bleeding or an under-dosing may lead to clotting of the blood. Hence, it is important to find clues and leads to enable medical professionals to determine if individual patients are to be on high or low dose warfarin requirements.
The search for protein biomarkers which helps to differentiate patients on low-dose warfarin requirement from those on high-dose warfarin requirement is the aim and target of this project. An iTRAQ coupled LC-MS/MS approach will be taken to determine the protein biomarker.
From present and past results obtained, TP, a protein biomarker has been found significant in patients on low-dose warfarin and is absent in all high-dose warfarin patients. This observation has led us to determine this protein as our target protein biomarker for patients who are on low-dose warfarin requirement.
This finding could potentially minimize the risk of over-dose during warfarin induction. |
| first_indexed | 2024-10-01T03:29:37Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/16589 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:29:37Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | ntu-10356/165892023-03-03T15:33:34Z Identification of biomarker in patients on low dose warfarin : an iTRAQ-coupled LC-MS/MS approach Koh, Regina Hwee Chen. Chen Wei Ning, William School of Chemical and Biomedical Engineering DRNTU::Engineering::Chemical engineering::Biotechnology Warfarin is one of the most widely used oral anticoagulant. However, the dosage of warfarin given to patients is very critical as an overdose may lead to severe bleeding or an under-dosing may lead to clotting of the blood. Hence, it is important to find clues and leads to enable medical professionals to determine if individual patients are to be on high or low dose warfarin requirements. The search for protein biomarkers which helps to differentiate patients on low-dose warfarin requirement from those on high-dose warfarin requirement is the aim and target of this project. An iTRAQ coupled LC-MS/MS approach will be taken to determine the protein biomarker. From present and past results obtained, TP, a protein biomarker has been found significant in patients on low-dose warfarin and is absent in all high-dose warfarin patients. This observation has led us to determine this protein as our target protein biomarker for patients who are on low-dose warfarin requirement. This finding could potentially minimize the risk of over-dose during warfarin induction. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2009-05-27T04:47:35Z 2009-05-27T04:47:35Z 2009 2009 Final Year Project (FYP) http://hdl.handle.net/10356/16589 en Nanyang Technological University 46 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Chemical engineering::Biotechnology Koh, Regina Hwee Chen. Identification of biomarker in patients on low dose warfarin : an iTRAQ-coupled LC-MS/MS approach |
| title | Identification of biomarker in patients on low dose warfarin : an iTRAQ-coupled LC-MS/MS approach |
| title_full | Identification of biomarker in patients on low dose warfarin : an iTRAQ-coupled LC-MS/MS approach |
| title_fullStr | Identification of biomarker in patients on low dose warfarin : an iTRAQ-coupled LC-MS/MS approach |
| title_full_unstemmed | Identification of biomarker in patients on low dose warfarin : an iTRAQ-coupled LC-MS/MS approach |
| title_short | Identification of biomarker in patients on low dose warfarin : an iTRAQ-coupled LC-MS/MS approach |
| title_sort | identification of biomarker in patients on low dose warfarin an itraq coupled lc ms ms approach |
| topic | DRNTU::Engineering::Chemical engineering::Biotechnology |
| url | http://hdl.handle.net/10356/16589 |
| work_keys_str_mv | AT kohreginahweechen identificationofbiomarkerinpatientsonlowdosewarfarinanitraqcoupledlcmsmsapproach |