Catalytic enantioselective addition of diethylzinc to ketones using chiral biisoquinoline ligands.
Biisoquinolines have been known to be good chelating agents. Four chiral biisoquinoline-based ligands were synthesized and used for asymmetric catalytic addition of diethylzinc to ketones. The reaction was tested for optimal conditions – type of ligands, catalyst loading, temperature, type of sol...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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2009
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| Online Access: | http://hdl.handle.net/10356/16597 |
| _version_ | 1811695479271981056 |
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| author | Muhammad Firdaus Abdul Raub. |
| author2 | Zaher Judeh |
| author_facet | Zaher Judeh Muhammad Firdaus Abdul Raub. |
| author_sort | Muhammad Firdaus Abdul Raub. |
| collection | NTU |
| description | Biisoquinolines have been known to be good chelating agents. Four chiral
biisoquinoline-based ligands were synthesized and used for asymmetric catalytic addition
of diethylzinc to ketones. The reaction was tested for optimal conditions – type of
ligands, catalyst loading, temperature, type of solvent, and the reaction time – with
acetophenone as substrate. Under the optimum reaction conditions obtained, the catalytic
reaction was carried out with other various ketones to see the influence of changes to
ketone structures on the enantiomeric excess and yield of the products. HPLC analysis
have shown encouraging results of moderate to excellent enantioselectivities of up to
90%, thus promoting future investigations in the application of the synthesized ligands to
other ketones and even other types of asymmetric additions. |
| first_indexed | 2024-10-01T07:24:07Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/16597 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:24:07Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | ntu-10356/165972023-03-03T15:39:04Z Catalytic enantioselective addition of diethylzinc to ketones using chiral biisoquinoline ligands. Muhammad Firdaus Abdul Raub. Zaher Judeh School of Chemical and Biomedical Engineering DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis DRNTU::Engineering::Chemical engineering::Biochemical engineering Biisoquinolines have been known to be good chelating agents. Four chiral biisoquinoline-based ligands were synthesized and used for asymmetric catalytic addition of diethylzinc to ketones. The reaction was tested for optimal conditions – type of ligands, catalyst loading, temperature, type of solvent, and the reaction time – with acetophenone as substrate. Under the optimum reaction conditions obtained, the catalytic reaction was carried out with other various ketones to see the influence of changes to ketone structures on the enantiomeric excess and yield of the products. HPLC analysis have shown encouraging results of moderate to excellent enantioselectivities of up to 90%, thus promoting future investigations in the application of the synthesized ligands to other ketones and even other types of asymmetric additions. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2009-05-27T06:07:03Z 2009-05-27T06:07:03Z 2009 2009 Final Year Project (FYP) http://hdl.handle.net/10356/16597 en Nanyang Technological University 71 p. application/pdf |
| spellingShingle | DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis DRNTU::Engineering::Chemical engineering::Biochemical engineering Muhammad Firdaus Abdul Raub. Catalytic enantioselective addition of diethylzinc to ketones using chiral biisoquinoline ligands. |
| title | Catalytic enantioselective addition of diethylzinc to ketones using chiral biisoquinoline ligands. |
| title_full | Catalytic enantioselective addition of diethylzinc to ketones using chiral biisoquinoline ligands. |
| title_fullStr | Catalytic enantioselective addition of diethylzinc to ketones using chiral biisoquinoline ligands. |
| title_full_unstemmed | Catalytic enantioselective addition of diethylzinc to ketones using chiral biisoquinoline ligands. |
| title_short | Catalytic enantioselective addition of diethylzinc to ketones using chiral biisoquinoline ligands. |
| title_sort | catalytic enantioselective addition of diethylzinc to ketones using chiral biisoquinoline ligands |
| topic | DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis DRNTU::Engineering::Chemical engineering::Biochemical engineering |
| url | http://hdl.handle.net/10356/16597 |
| work_keys_str_mv | AT muhammadfirdausabdulraub catalyticenantioselectiveadditionofdiethylzinctoketonesusingchiralbiisoquinolineligands |