CFD modeling of pulmonary drug delivery.
The lung has been studied as a possible route of administration for the treatment of systemic diseases. It provides direct access to disease in the treatment of respiratory diseases, while providing an enormous surface area and a relatively low enzymatic, controlled environment for systemic absorpt...
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| Other Authors: | |
| Format: | Final Year Project (FYP) |
| Language: | English |
| Published: |
2009
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/16599 |
| _version_ | 1811694609935368192 |
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| author | Sin, Jasper Tuck Seng. |
| author2 | Lau Wai Man |
| author_facet | Lau Wai Man Sin, Jasper Tuck Seng. |
| author_sort | Sin, Jasper Tuck Seng. |
| collection | NTU |
| description | The lung has been studied as a possible route of administration for the treatment
of systemic diseases. It provides direct access to disease in the treatment of respiratory diseases, while providing an enormous surface area and a relatively low enzymatic, controlled environment for systemic absorptions of medications. Pulmonary drug delivery has the advantage that it can deliver drugs directly to the region of therapeutic treatment, hence requiring lower medicine doses. The oral and nasal airways are forms of entry into the human respiratory tract. Resistance through the oral airways is much lower as compared to the nasal airways and thus, aerosol drugs are often delivered through inhalation via the oral airways. The purpose of this study was to investigate the effects of inhalation rate and particle size on the deposition in the human airway. Computational fluid dynamics (CFD) simulations of airflow and particle deposition was conducted for particle size ranging from 5μm to 100μm, and inhalation rates ranging from 30l/min to
60l/min. Laminar, multiphase mixture model was used and the forces included in the
simulation are drag and gravity. Deposition occurs mainly by inertial impact and generally increases with the increase in inhalation rate and particle size. |
| first_indexed | 2024-10-01T07:10:18Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/16599 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:10:18Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | ntu-10356/165992023-03-03T15:38:45Z CFD modeling of pulmonary drug delivery. Sin, Jasper Tuck Seng. Lau Wai Man School of Chemical and Biomedical Engineering DRNTU::Engineering::Chemical engineering::Biotechnology The lung has been studied as a possible route of administration for the treatment of systemic diseases. It provides direct access to disease in the treatment of respiratory diseases, while providing an enormous surface area and a relatively low enzymatic, controlled environment for systemic absorptions of medications. Pulmonary drug delivery has the advantage that it can deliver drugs directly to the region of therapeutic treatment, hence requiring lower medicine doses. The oral and nasal airways are forms of entry into the human respiratory tract. Resistance through the oral airways is much lower as compared to the nasal airways and thus, aerosol drugs are often delivered through inhalation via the oral airways. The purpose of this study was to investigate the effects of inhalation rate and particle size on the deposition in the human airway. Computational fluid dynamics (CFD) simulations of airflow and particle deposition was conducted for particle size ranging from 5μm to 100μm, and inhalation rates ranging from 30l/min to 60l/min. Laminar, multiphase mixture model was used and the forces included in the simulation are drag and gravity. Deposition occurs mainly by inertial impact and generally increases with the increase in inhalation rate and particle size. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2009-05-27T06:15:05Z 2009-05-27T06:15:05Z 2009 2009 Final Year Project (FYP) http://hdl.handle.net/10356/16599 en Nanyang Technological University 83 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Chemical engineering::Biotechnology Sin, Jasper Tuck Seng. CFD modeling of pulmonary drug delivery. |
| title | CFD modeling of pulmonary drug delivery. |
| title_full | CFD modeling of pulmonary drug delivery. |
| title_fullStr | CFD modeling of pulmonary drug delivery. |
| title_full_unstemmed | CFD modeling of pulmonary drug delivery. |
| title_short | CFD modeling of pulmonary drug delivery. |
| title_sort | cfd modeling of pulmonary drug delivery |
| topic | DRNTU::Engineering::Chemical engineering::Biotechnology |
| url | http://hdl.handle.net/10356/16599 |
| work_keys_str_mv | AT sinjaspertuckseng cfdmodelingofpulmonarydrugdelivery |