Salt-triggered adaptive dissociation coating with dual effect of antibacteria and anti-multiple encrustations in urological devices
Bacterial infections and multiple encrustations are life-threatening complications in patients implanted with urological devices. Limited by time-consuming procedures and substrate dependence, it is difficult to simultaneously prevent the aforementioned complications. Herein, is reported the design...
| Main Authors: | , , , , , , , , , |
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| 其他作者: | |
| 格式: | Journal Article |
| 语言: | English |
| 出版: |
2023
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| 主题: | |
| 在线阅读: | https://hdl.handle.net/10356/166405 |
| _version_ | 1826112762729725952 |
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| author | Yu, Huan Shi, Hengchong Zhu, Ming Zhang, Xu Wang, Lei Tian, Gongwei Song, Lingjie Luan, Shifang Qi, Dianpeng Chen, Xiaodong |
| author2 | School of Materials Science and Engineering |
| author_facet | School of Materials Science and Engineering Yu, Huan Shi, Hengchong Zhu, Ming Zhang, Xu Wang, Lei Tian, Gongwei Song, Lingjie Luan, Shifang Qi, Dianpeng Chen, Xiaodong |
| author_sort | Yu, Huan |
| collection | NTU |
| description | Bacterial infections and multiple encrustations are life-threatening complications in patients implanted with urological devices. Limited by time-consuming procedures and substrate dependence, it is difficult to simultaneously prevent the aforementioned complications. Herein, is reported the design of a salt-triggered chondroitin sulfate complex (CS/Si-N+ ) coating with adaptive dissociation, which realizes the dual functions of antibacterial and anti-multiple encrustations in urological devices with arbitrary shapes. The existence of covalent interactions between the complex and the interface ensures the formation of a robust coating, especially in harsh environments. Benefiting from the adaptive dissociation of the ion pairs in the CS/Si-N+ coating in urine electrolytes, the exposed ion groups and enhanced hydrophilicity are more conducive to the inhibition of bacterial infection and multiple encrustations simultaneously. The coating exhibits broad-spectrum bactericidal effects. As a proof of concept, in a simulated metabolic encrustation model, the coating exhibits significant advantages in resisting calcium oxalate encrustation, with a reduction in the calcium content by over 90%. In addition, this non-leachable all-in-one coating shows good biocompatibility in a pig in vivo model. Such a coating strategy is expected to be a practical approach for preventing urological medical device-related complications. |
| first_indexed | 2024-10-01T03:12:27Z |
| format | Journal Article |
| id | ntu-10356/166405 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:12:27Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1664052023-04-24T07:49:14Z Salt-triggered adaptive dissociation coating with dual effect of antibacteria and anti-multiple encrustations in urological devices Yu, Huan Shi, Hengchong Zhu, Ming Zhang, Xu Wang, Lei Tian, Gongwei Song, Lingjie Luan, Shifang Qi, Dianpeng Chen, Xiaodong School of Materials Science and Engineering Institute for Digital Molecular Analytics and Science (IDMxS) Engineering::Materials Biocompatibility Infectious Encrustation Bacterial infections and multiple encrustations are life-threatening complications in patients implanted with urological devices. Limited by time-consuming procedures and substrate dependence, it is difficult to simultaneously prevent the aforementioned complications. Herein, is reported the design of a salt-triggered chondroitin sulfate complex (CS/Si-N+ ) coating with adaptive dissociation, which realizes the dual functions of antibacterial and anti-multiple encrustations in urological devices with arbitrary shapes. The existence of covalent interactions between the complex and the interface ensures the formation of a robust coating, especially in harsh environments. Benefiting from the adaptive dissociation of the ion pairs in the CS/Si-N+ coating in urine electrolytes, the exposed ion groups and enhanced hydrophilicity are more conducive to the inhibition of bacterial infection and multiple encrustations simultaneously. The coating exhibits broad-spectrum bactericidal effects. As a proof of concept, in a simulated metabolic encrustation model, the coating exhibits significant advantages in resisting calcium oxalate encrustation, with a reduction in the calcium content by over 90%. In addition, this non-leachable all-in-one coating shows good biocompatibility in a pig in vivo model. Such a coating strategy is expected to be a practical approach for preventing urological medical device-related complications. This work is supported by National Natural Science Foundation of China (Grant Nos. 51973221, 52173237, 22107099, and 52293384), Youth Innovation Promotion Association of CAS (Grant No. Y2021066), National Key Research and Development Program of China (Grant Nos.2020YFC1106900 and 2021YFC2101700), Scientific and Technological Development Program of Jilin Province (Grant No. 20210101385JC), and High-Tech Research & Development Program of CAS-WEGO Group. 2023-04-24T07:49:13Z 2023-04-24T07:49:13Z 2023 Journal Article Yu, H., Shi, H., Zhu, M., Zhang, X., Wang, L., Tian, G., Song, L., Luan, S., Qi, D. & Chen, X. (2023). Salt-triggered adaptive dissociation coating with dual effect of antibacteria and anti-multiple encrustations in urological devices. Advanced Healthcare Materials. https://dx.doi.org/10.1002/adhm.202203328 2192-2640 https://hdl.handle.net/10356/166405 10.1002/adhm.202203328 36854258 2-s2.0-85150632067 en Advanced Healthcare Materials © 2023 Wiley-VCH GmbH. All rights reserved. |
| spellingShingle | Engineering::Materials Biocompatibility Infectious Encrustation Yu, Huan Shi, Hengchong Zhu, Ming Zhang, Xu Wang, Lei Tian, Gongwei Song, Lingjie Luan, Shifang Qi, Dianpeng Chen, Xiaodong Salt-triggered adaptive dissociation coating with dual effect of antibacteria and anti-multiple encrustations in urological devices |
| title | Salt-triggered adaptive dissociation coating with dual effect of antibacteria and anti-multiple encrustations in urological devices |
| title_full | Salt-triggered adaptive dissociation coating with dual effect of antibacteria and anti-multiple encrustations in urological devices |
| title_fullStr | Salt-triggered adaptive dissociation coating with dual effect of antibacteria and anti-multiple encrustations in urological devices |
| title_full_unstemmed | Salt-triggered adaptive dissociation coating with dual effect of antibacteria and anti-multiple encrustations in urological devices |
| title_short | Salt-triggered adaptive dissociation coating with dual effect of antibacteria and anti-multiple encrustations in urological devices |
| title_sort | salt triggered adaptive dissociation coating with dual effect of antibacteria and anti multiple encrustations in urological devices |
| topic | Engineering::Materials Biocompatibility Infectious Encrustation |
| url | https://hdl.handle.net/10356/166405 |
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