Effects of different stimuli on the properties of a triple-crosslinked hydrogel
Hydrogels with multiple modes of crosslinking have emerged as promising candidates for biomedical applications due to their improved mechanical properties using multiple stimuli. In this study, branched thermoresponsive copolymer with amine end groups (PPG-PEI) was crosslinked with oxidized alginate...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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Nanyang Technological University
2023
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| Online Access: | https://hdl.handle.net/10356/167241 |
| _version_ | 1826118979703275520 |
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| author | Yip, Ying |
| author2 | Tan Lay Poh |
| author_facet | Tan Lay Poh Yip, Ying |
| author_sort | Yip, Ying |
| collection | NTU |
| description | Hydrogels with multiple modes of crosslinking have emerged as promising candidates for biomedical applications due to their improved mechanical properties using multiple stimuli. In this study, branched thermoresponsive copolymer with amine end groups (PPG-PEI) was crosslinked with oxidized alginate (OA) and Ca2+ to form dual-crosslinked (PPG-PEI-OA) and triple-crosslinked hydrogels (PPG-PEI-OA(Ca2+)), which demonstrated responsiveness to temperature, pH, and Ca2+ stimuli. Higher degree of oxidation of alginate reduced the molecular weight of OA, decreasing the thermal stability
and gel stiffness. The combination of thermal-induced and Schiff base crosslinking significantly improved mechanical stiffness of hydrogel, while the subsequent addition of Ca2+ unexpectedly reduced stiffness due to swelling. Furthermore, higher pH values improved the gel stiffness of the crosslinked hydrogels. Expectedly, PPG-PEI-OA(Ca2+)
showed slower protein release and degradation rates compared to PPG-PEI-OA,
indicating that the additional Ca2+ crosslinking decreased the hydrogel’s mesh size and enhanced its stability. This suggests that hydrogels with multiple crosslinks in response to different stimuli have potential for a range of biomedical applications, allowing the users to control each parameter to achieve a gel with their desired stiffness, degradation and drug release speed for their specific applications. |
| first_indexed | 2024-10-01T04:52:27Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/167241 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:52:27Z |
| publishDate | 2023 |
| publisher | Nanyang Technological University |
| record_format | dspace |
| spelling | ntu-10356/1672412023-05-12T05:43:32Z Effects of different stimuli on the properties of a triple-crosslinked hydrogel Yip, Ying Tan Lay Poh School of Materials Science and Engineering A*STAR Institute of Material Research and Engineering LPTan@ntu.edu.sg Engineering::Materials Hydrogels with multiple modes of crosslinking have emerged as promising candidates for biomedical applications due to their improved mechanical properties using multiple stimuli. In this study, branched thermoresponsive copolymer with amine end groups (PPG-PEI) was crosslinked with oxidized alginate (OA) and Ca2+ to form dual-crosslinked (PPG-PEI-OA) and triple-crosslinked hydrogels (PPG-PEI-OA(Ca2+)), which demonstrated responsiveness to temperature, pH, and Ca2+ stimuli. Higher degree of oxidation of alginate reduced the molecular weight of OA, decreasing the thermal stability and gel stiffness. The combination of thermal-induced and Schiff base crosslinking significantly improved mechanical stiffness of hydrogel, while the subsequent addition of Ca2+ unexpectedly reduced stiffness due to swelling. Furthermore, higher pH values improved the gel stiffness of the crosslinked hydrogels. Expectedly, PPG-PEI-OA(Ca2+) showed slower protein release and degradation rates compared to PPG-PEI-OA, indicating that the additional Ca2+ crosslinking decreased the hydrogel’s mesh size and enhanced its stability. This suggests that hydrogels with multiple crosslinks in response to different stimuli have potential for a range of biomedical applications, allowing the users to control each parameter to achieve a gel with their desired stiffness, degradation and drug release speed for their specific applications. Bachelor of Engineering (Materials Engineering) 2023-05-11T06:31:07Z 2023-05-11T06:31:07Z 2023 Final Year Project (FYP) Yip, Y. (2023). Effects of different stimuli on the properties of a triple-crosslinked hydrogel. Final Year Project (FYP), Nanyang Technological University, Singapore. https://hdl.handle.net/10356/167241 https://hdl.handle.net/10356/167241 en application/pdf Nanyang Technological University |
| spellingShingle | Engineering::Materials Yip, Ying Effects of different stimuli on the properties of a triple-crosslinked hydrogel |
| title | Effects of different stimuli on the properties of a triple-crosslinked hydrogel |
| title_full | Effects of different stimuli on the properties of a triple-crosslinked hydrogel |
| title_fullStr | Effects of different stimuli on the properties of a triple-crosslinked hydrogel |
| title_full_unstemmed | Effects of different stimuli on the properties of a triple-crosslinked hydrogel |
| title_short | Effects of different stimuli on the properties of a triple-crosslinked hydrogel |
| title_sort | effects of different stimuli on the properties of a triple crosslinked hydrogel |
| topic | Engineering::Materials |
| url | https://hdl.handle.net/10356/167241 |
| work_keys_str_mv | AT yipying effectsofdifferentstimulionthepropertiesofatriplecrosslinkedhydrogel |