Ceramide acyl chain length and its relevance to intracellular lipid regulation
Ceramides are a class of sphingolipids which are implicated in skin disorders, obesity, and other metabolic diseases. As a class with pleiotropic effects, recent efforts have centred on discerning specific ceramide species and their effects on atopic dermatitis, obesity, type 2 diabetes, and cardiov...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://hdl.handle.net/10356/168549 |
| _version_ | 1811678770558402560 |
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| author | Ho, Calvin Qing Wei Zheng, Xiaofeng Yusuf Ali |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Ho, Calvin Qing Wei Zheng, Xiaofeng Yusuf Ali |
| author_sort | Ho, Calvin Qing Wei |
| collection | NTU |
| description | Ceramides are a class of sphingolipids which are implicated in skin disorders, obesity, and other metabolic diseases. As a class with pleiotropic effects, recent efforts have centred on discerning specific ceramide species and their effects on atopic dermatitis, obesity, type 2 diabetes, and cardiovascular diseases. This delineation has allowed the identification of disease biomarkers, with long acyl chain ceramides such as C16- and C18-ceramides linked to metabolic dysfunction and cardiac function decline, while ultra-long acyl chain ceramides (>25 carbon acyl chain) were reported to be essential for maintaining a functional skin barrier. Given the intricate link between free fatty acids with ceramides, especially the de novo synthetic pathway, intracellular lipid droplet formation is increasingly viewed as an important mechanism for preventing accumulation of toxic ceramide species. Here, we review recent reports of various ceramide species involved in skin abnormalities and metabolic diseases, and we propose that promotion of lipid droplet biogenesis can be seen as a potential protective mechanism against deleterious ceramides. |
| first_indexed | 2024-10-01T02:58:33Z |
| format | Journal Article |
| id | ntu-10356/168549 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:58:33Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1685492023-06-11T15:41:06Z Ceramide acyl chain length and its relevance to intracellular lipid regulation Ho, Calvin Qing Wei Zheng, Xiaofeng Yusuf Ali Lee Kong Chian School of Medicine (LKCMedicine) Singapore Eye Research Institute Science::Medicine Ceramides Lipid Droplets Ceramides are a class of sphingolipids which are implicated in skin disorders, obesity, and other metabolic diseases. As a class with pleiotropic effects, recent efforts have centred on discerning specific ceramide species and their effects on atopic dermatitis, obesity, type 2 diabetes, and cardiovascular diseases. This delineation has allowed the identification of disease biomarkers, with long acyl chain ceramides such as C16- and C18-ceramides linked to metabolic dysfunction and cardiac function decline, while ultra-long acyl chain ceramides (>25 carbon acyl chain) were reported to be essential for maintaining a functional skin barrier. Given the intricate link between free fatty acids with ceramides, especially the de novo synthetic pathway, intracellular lipid droplet formation is increasingly viewed as an important mechanism for preventing accumulation of toxic ceramide species. Here, we review recent reports of various ceramide species involved in skin abnormalities and metabolic diseases, and we propose that promotion of lipid droplet biogenesis can be seen as a potential protective mechanism against deleterious ceramides. Ministry of Education (MOE) Published version This work was funded by the Ministry of Education Singapore (MOE2018-T2-1-085, MOET2EP30221-0003) (Y.A.) and Tier 1 (2019-T1-001-059) (Y.A.). This work is also partly supported by the Program of National Natural Science Foundation of China (82070846) (X.Z.), the Program for Overseas High-Level Talents Introduction of Sichuan Province of China (21RCYJ0046) (X.Z.). 2023-06-05T06:41:28Z 2023-06-05T06:41:28Z 2022 Journal Article Ho, C. Q. W., Zheng, X. & Yusuf Ali (2022). Ceramide acyl chain length and its relevance to intracellular lipid regulation. International Journal of Molecular Sciences, 23(17), 9697-. https://dx.doi.org/10.3390/ijms23179697 1661-6596 https://hdl.handle.net/10356/168549 10.3390/ijms23179697 36077094 2-s2.0-85137593481 17 23 9697 en MOE2018-T2-1-085 MOET2EP30221-0003 2019-T1-001-059 International Journal of Molecular Sciences © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). application/pdf |
| spellingShingle | Science::Medicine Ceramides Lipid Droplets Ho, Calvin Qing Wei Zheng, Xiaofeng Yusuf Ali Ceramide acyl chain length and its relevance to intracellular lipid regulation |
| title | Ceramide acyl chain length and its relevance to intracellular lipid regulation |
| title_full | Ceramide acyl chain length and its relevance to intracellular lipid regulation |
| title_fullStr | Ceramide acyl chain length and its relevance to intracellular lipid regulation |
| title_full_unstemmed | Ceramide acyl chain length and its relevance to intracellular lipid regulation |
| title_short | Ceramide acyl chain length and its relevance to intracellular lipid regulation |
| title_sort | ceramide acyl chain length and its relevance to intracellular lipid regulation |
| topic | Science::Medicine Ceramides Lipid Droplets |
| url | https://hdl.handle.net/10356/168549 |
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