Accelerated degradation of poly-ε-caprolactone composite scaffolds for large bone defects
This research investigates the accelerated hydrolytic degradation process of both anatomically designed bone scaffolds with a pore size gradient and a rectangular shape (biomimetically designed scaffolds or bone bricks). The effect of material composition is investigated considering poly-ε-caprolact...
| المؤلفون الرئيسيون: | , , , , , , , , , |
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| مؤلفون آخرون: | |
| التنسيق: | Journal Article |
| اللغة: | English |
| منشور في: |
2023
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://hdl.handle.net/10356/168787 |
| _version_ | 1826125001066020864 |
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| author | Daskalakis, Evangelos Hassan, Mohamed H. Omar, Abdalla M. Acar, Anil A. Fallah, Ali Cooper, Glen Weightman, Andrew Blunn, Gordon Koc, Bahattin Bartolo, Paulo |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Daskalakis, Evangelos Hassan, Mohamed H. Omar, Abdalla M. Acar, Anil A. Fallah, Ali Cooper, Glen Weightman, Andrew Blunn, Gordon Koc, Bahattin Bartolo, Paulo |
| author_sort | Daskalakis, Evangelos |
| collection | NTU |
| description | This research investigates the accelerated hydrolytic degradation process of both anatomically designed bone scaffolds with a pore size gradient and a rectangular shape (biomimetically designed scaffolds or bone bricks). The effect of material composition is investigated considering poly-ε-caprolactone (PCL) as the main scaffold material, reinforced with ceramics such as hydroxyapatite (HA), β-tricalcium phosphate (TCP) and bioglass at a concentration of 20 wt%. In the case of rectangular scaffolds, the effect of pore size (200 μm, 300 μm and 500 μm) is also investigated. The degradation process (accelerated degradation) was investigated during a period of 5 days in a sodium hydroxide (NaOH) medium. Degraded bone bricks and rectangular scaffolds were measured each day to evaluate the weight loss of the samples, which were also morphologically, thermally, chemically and mechanically assessed. The results show that the PCL/bioglass bone brick scaffolds exhibited faster degradation kinetics in comparison with the PCL, PCL/HA and PCL/TCP bone bricks. Furthermore, the degradation kinetics of rectangular scaffolds increased by increasing the pore size from 500 μm to 200 μm. The results also indicate that, for the same material composition, bone bricks degrade slower compared with rectangular scaffolds. The scanning electron microscopy (SEM) images show that the degradation process was faster on the external regions of the bone brick scaffolds (600 μm pore size) compared with the internal regions (200 μm pore size). The thermal gravimetric analysis (TGA) results show that the ceramic concentration remained constant throughout the degradation process, while differential scanning calorimetry (DSC) results show that all scaffolds exhibited a reduction in crystallinity (Xc), enthalpy (Δm) and melting temperature (Tm) throughout the degradation process, while the glass transition temperature (Tg) slightly increased. Finally, the compression results show that the mechanical properties decreased during the degradation process, with PCL/bioglass bone bricks and rectangular scaffolds presenting higher mechanical properties with the same design in comparison with the other materials. |
| first_indexed | 2024-10-01T06:29:35Z |
| format | Journal Article |
| id | ntu-10356/168787 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:29:35Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1687872023-06-21T15:37:26Z Accelerated degradation of poly-ε-caprolactone composite scaffolds for large bone defects Daskalakis, Evangelos Hassan, Mohamed H. Omar, Abdalla M. Acar, Anil A. Fallah, Ali Cooper, Glen Weightman, Andrew Blunn, Gordon Koc, Bahattin Bartolo, Paulo School of Mechanical and Aerospace Engineering Singapore Centre for 3D Printing Engineering::Mechanical engineering 3D Printing Additive Manufacturing This research investigates the accelerated hydrolytic degradation process of both anatomically designed bone scaffolds with a pore size gradient and a rectangular shape (biomimetically designed scaffolds or bone bricks). The effect of material composition is investigated considering poly-ε-caprolactone (PCL) as the main scaffold material, reinforced with ceramics such as hydroxyapatite (HA), β-tricalcium phosphate (TCP) and bioglass at a concentration of 20 wt%. In the case of rectangular scaffolds, the effect of pore size (200 μm, 300 μm and 500 μm) is also investigated. The degradation process (accelerated degradation) was investigated during a period of 5 days in a sodium hydroxide (NaOH) medium. Degraded bone bricks and rectangular scaffolds were measured each day to evaluate the weight loss of the samples, which were also morphologically, thermally, chemically and mechanically assessed. The results show that the PCL/bioglass bone brick scaffolds exhibited faster degradation kinetics in comparison with the PCL, PCL/HA and PCL/TCP bone bricks. Furthermore, the degradation kinetics of rectangular scaffolds increased by increasing the pore size from 500 μm to 200 μm. The results also indicate that, for the same material composition, bone bricks degrade slower compared with rectangular scaffolds. The scanning electron microscopy (SEM) images show that the degradation process was faster on the external regions of the bone brick scaffolds (600 μm pore size) compared with the internal regions (200 μm pore size). The thermal gravimetric analysis (TGA) results show that the ceramic concentration remained constant throughout the degradation process, while differential scanning calorimetry (DSC) results show that all scaffolds exhibited a reduction in crystallinity (Xc), enthalpy (Δm) and melting temperature (Tm) throughout the degradation process, while the glass transition temperature (Tg) slightly increased. Finally, the compression results show that the mechanical properties decreased during the degradation process, with PCL/bioglass bone bricks and rectangular scaffolds presenting higher mechanical properties with the same design in comparison with the other materials. Published version This project was supported by the University of Manchester and the Engineering and Physical Sciences Research Council (EPSRC) of the U.K. and the Global Challenges Research Fund (GCRF), grant number EP/R01513/1. 2023-06-19T06:31:47Z 2023-06-19T06:31:47Z 2023 Journal Article Daskalakis, E., Hassan, M. H., Omar, A. M., Acar, A. A., Fallah, A., Cooper, G., Weightman, A., Blunn, G., Koc, B. & Bartolo, P. (2023). Accelerated degradation of poly-ε-caprolactone composite scaffolds for large bone defects. Polymers, 15(3), 670-. https://dx.doi.org/10.3390/polym15030670 2073-4360 https://hdl.handle.net/10356/168787 10.3390/polym15030670 36771970 2-s2.0-85147843037 3 15 670 en Polymers © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/4.0/). application/pdf |
| spellingShingle | Engineering::Mechanical engineering 3D Printing Additive Manufacturing Daskalakis, Evangelos Hassan, Mohamed H. Omar, Abdalla M. Acar, Anil A. Fallah, Ali Cooper, Glen Weightman, Andrew Blunn, Gordon Koc, Bahattin Bartolo, Paulo Accelerated degradation of poly-ε-caprolactone composite scaffolds for large bone defects |
| title | Accelerated degradation of poly-ε-caprolactone composite scaffolds for large bone defects |
| title_full | Accelerated degradation of poly-ε-caprolactone composite scaffolds for large bone defects |
| title_fullStr | Accelerated degradation of poly-ε-caprolactone composite scaffolds for large bone defects |
| title_full_unstemmed | Accelerated degradation of poly-ε-caprolactone composite scaffolds for large bone defects |
| title_short | Accelerated degradation of poly-ε-caprolactone composite scaffolds for large bone defects |
| title_sort | accelerated degradation of poly ε caprolactone composite scaffolds for large bone defects |
| topic | Engineering::Mechanical engineering 3D Printing Additive Manufacturing |
| url | https://hdl.handle.net/10356/168787 |
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