The link between neuroinflammation and the neurovascular unit in synucleinopathies
The neurovascular unit (NVU) is composed of vascular cells, glial cells, and neurons. As a fundamental functional module in the central nervous system, the NVU maintains homeostasis in the microenvironment and the integrity of the blood-brain barrier. Disruption of the NVU and interactions among its...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://hdl.handle.net/10356/168802 |
| _version_ | 1826110544824762368 |
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| author | Wang, Qing Zheng, Jialing Pettersson, Sven Reynolds, Richard Tan, Eng-King |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Wang, Qing Zheng, Jialing Pettersson, Sven Reynolds, Richard Tan, Eng-King |
| author_sort | Wang, Qing |
| collection | NTU |
| description | The neurovascular unit (NVU) is composed of vascular cells, glial cells, and neurons. As a fundamental functional module in the central nervous system, the NVU maintains homeostasis in the microenvironment and the integrity of the blood-brain barrier. Disruption of the NVU and interactions among its components are involved in the pathophysiology of synucleinopathies, which are characterized by the pathological accumulation of α-synuclein. Neuroinflammation contributes to the pathophysiology of synucleinopathies, including Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies. This review aims to summarize the neuroinflammatory response of glial cells and vascular cells in the NVU. We also review neuroinflammation in the context of the cross-talk between glial cells and vascular cells, between glial cells and pericytes, and between microglia and astroglia. Last, we discuss how α-synuclein affects neuroinflammation and how neuroinflammation influences the aggregation and spread of α-synuclein and analyze different properties of α-synuclein in synucleinopathies. |
| first_indexed | 2024-10-01T02:36:12Z |
| format | Journal Article |
| id | ntu-10356/168802 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:36:12Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1688022023-06-25T15:37:35Z The link between neuroinflammation and the neurovascular unit in synucleinopathies Wang, Qing Zheng, Jialing Pettersson, Sven Reynolds, Richard Tan, Eng-King Lee Kong Chian School of Medicine (LKCMedicine) Centre for Molecular Neuropathology Science::Medicine Central Nervous Systems Functional Modules The neurovascular unit (NVU) is composed of vascular cells, glial cells, and neurons. As a fundamental functional module in the central nervous system, the NVU maintains homeostasis in the microenvironment and the integrity of the blood-brain barrier. Disruption of the NVU and interactions among its components are involved in the pathophysiology of synucleinopathies, which are characterized by the pathological accumulation of α-synuclein. Neuroinflammation contributes to the pathophysiology of synucleinopathies, including Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies. This review aims to summarize the neuroinflammatory response of glial cells and vascular cells in the NVU. We also review neuroinflammation in the context of the cross-talk between glial cells and vascular cells, between glial cells and pericytes, and between microglia and astroglia. Last, we discuss how α-synuclein affects neuroinflammation and how neuroinflammation influences the aggregation and spread of α-synuclein and analyze different properties of α-synuclein in synucleinopathies. National Medical Research Council (NMRC) Published version This work was supported by the National Natural Science Foundation of China (no.82071414), Leading Talent in Talents Project Guangdong High-level Personnel of Special Support Program, Scientific Research Foundation of Guangzhou (no. 202206010005) to Q.W., ASEAN microbiome nutrition centre to SP, CIFAR to SP, and National Medical Research Council Singapore to E.-K.T. 2023-06-19T07:33:46Z 2023-06-19T07:33:46Z 2023 Journal Article Wang, Q., Zheng, J., Pettersson, S., Reynolds, R. & Tan, E. (2023). The link between neuroinflammation and the neurovascular unit in synucleinopathies. Science Advances, 9(7), eabq1141-. https://dx.doi.org/10.1126/sciadv.abq1141 2375-2548 https://hdl.handle.net/10356/168802 10.1126/sciadv.abq1141 36791205 2-s2.0-85148115136 7 9 eabq1141 en Science Advances © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). application/pdf |
| spellingShingle | Science::Medicine Central Nervous Systems Functional Modules Wang, Qing Zheng, Jialing Pettersson, Sven Reynolds, Richard Tan, Eng-King The link between neuroinflammation and the neurovascular unit in synucleinopathies |
| title | The link between neuroinflammation and the neurovascular unit in synucleinopathies |
| title_full | The link between neuroinflammation and the neurovascular unit in synucleinopathies |
| title_fullStr | The link between neuroinflammation and the neurovascular unit in synucleinopathies |
| title_full_unstemmed | The link between neuroinflammation and the neurovascular unit in synucleinopathies |
| title_short | The link between neuroinflammation and the neurovascular unit in synucleinopathies |
| title_sort | link between neuroinflammation and the neurovascular unit in synucleinopathies |
| topic | Science::Medicine Central Nervous Systems Functional Modules |
| url | https://hdl.handle.net/10356/168802 |
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