Gut microbiota in colorectal cancer: biological role and therapeutic opportunities
Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths worldwide. While CRC is thought to be an interplay between genetic and environmental factors, several lines of evidence suggest the involvement of gut microbiota in promoting inflammation and tumor progression. Gut microbio...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://hdl.handle.net/10356/168844 |
| _version_ | 1824453879327096832 |
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| author | Pandey, Himani Tang, Daryl W. T. Wong, Sunny Hei Lal, Devi |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Pandey, Himani Tang, Daryl W. T. Wong, Sunny Hei Lal, Devi |
| author_sort | Pandey, Himani |
| collection | NTU |
| description | Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths worldwide. While CRC is thought to be an interplay between genetic and environmental factors, several lines of evidence suggest the involvement of gut microbiota in promoting inflammation and tumor progression. Gut microbiota refer to the ~40 trillion microorganisms that inhabit the human gut. Advances in next-generation sequencing technologies and metagenomics have provided new insights into the gut microbial ecology and have helped in linking gut microbiota to CRC. Many studies carried out in humans and animal models have emphasized the role of certain gut bacteria, such as Fusobacterium nucleatum, enterotoxigenic Bacteroides fragilis, and colibactin-producing Escherichia coli, in the onset and progression of CRC. Metagenomic studies have opened up new avenues for the application of gut microbiota in the diagnosis, prevention, and treatment of CRC. This review article summarizes the role of gut microbiota in CRC development and its use as a biomarker to predict the disease and its potential therapeutic applications. |
| first_indexed | 2025-02-19T03:13:26Z |
| format | Journal Article |
| id | ntu-10356/168844 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:13:26Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1688442023-06-25T15:37:39Z Gut microbiota in colorectal cancer: biological role and therapeutic opportunities Pandey, Himani Tang, Daryl W. T. Wong, Sunny Hei Lal, Devi School of Biological Sciences Lee Kong Chian School of Medicine (LKCMedicine) Centre for Microbiome Medicine Science::Biological sciences Colorectal Cancer Microbiota Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths worldwide. While CRC is thought to be an interplay between genetic and environmental factors, several lines of evidence suggest the involvement of gut microbiota in promoting inflammation and tumor progression. Gut microbiota refer to the ~40 trillion microorganisms that inhabit the human gut. Advances in next-generation sequencing technologies and metagenomics have provided new insights into the gut microbial ecology and have helped in linking gut microbiota to CRC. Many studies carried out in humans and animal models have emphasized the role of certain gut bacteria, such as Fusobacterium nucleatum, enterotoxigenic Bacteroides fragilis, and colibactin-producing Escherichia coli, in the onset and progression of CRC. Metagenomic studies have opened up new avenues for the application of gut microbiota in the diagnosis, prevention, and treatment of CRC. This review article summarizes the role of gut microbiota in CRC development and its use as a biomarker to predict the disease and its potential therapeutic applications. Nanyang Technological University Published version The authors would like to acknowledge the NTU Start Up Grant (021337-00001) (S.W.) and the Wang Lee Wah Memorial Fund for support of this work. 2023-06-20T05:25:41Z 2023-06-20T05:25:41Z 2023 Journal Article Pandey, H., Tang, D. W. T., Wong, S. H. & Lal, D. (2023). Gut microbiota in colorectal cancer: biological role and therapeutic opportunities. Cancers, 15(3), 866-. https://dx.doi.org/10.3390/cancers15030866 2072-6694 https://hdl.handle.net/10356/168844 10.3390/cancers15030866 36765824 2-s2.0-85147803329 3 15 866 en NTU-SUG (021337-00001) Cancers © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). application/pdf |
| spellingShingle | Science::Biological sciences Colorectal Cancer Microbiota Pandey, Himani Tang, Daryl W. T. Wong, Sunny Hei Lal, Devi Gut microbiota in colorectal cancer: biological role and therapeutic opportunities |
| title | Gut microbiota in colorectal cancer: biological role and therapeutic opportunities |
| title_full | Gut microbiota in colorectal cancer: biological role and therapeutic opportunities |
| title_fullStr | Gut microbiota in colorectal cancer: biological role and therapeutic opportunities |
| title_full_unstemmed | Gut microbiota in colorectal cancer: biological role and therapeutic opportunities |
| title_short | Gut microbiota in colorectal cancer: biological role and therapeutic opportunities |
| title_sort | gut microbiota in colorectal cancer biological role and therapeutic opportunities |
| topic | Science::Biological sciences Colorectal Cancer Microbiota |
| url | https://hdl.handle.net/10356/168844 |
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