Gut-muscle crosstalk. a perspective on influence of microbes on muscle function
Our gastrointestinal system functions to digest and absorb ingested food, but it is also home to trillions of microbes that change across time, nutrition, lifestyle, and disease conditions. Largely commensals, these microbes are gaining prominence with regards to how they collectively affect the fun...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/168909 |
| _version_ | 1811688791266557952 |
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| author | Chew, Weixuan Lim, Yen Peng Lim, Wee Shiong Chambers, Edward S. Frost, Gary Wong, Sunny Hei Ali, Yusuf |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Chew, Weixuan Lim, Yen Peng Lim, Wee Shiong Chambers, Edward S. Frost, Gary Wong, Sunny Hei Ali, Yusuf |
| author_sort | Chew, Weixuan |
| collection | NTU |
| description | Our gastrointestinal system functions to digest and absorb ingested food, but it is also home to trillions of microbes that change across time, nutrition, lifestyle, and disease conditions. Largely commensals, these microbes are gaining prominence with regards to how they collectively affect the function of important metabolic organs, from the adipose tissues to the endocrine pancreas to the skeletal muscle. Muscle, as the biggest utilizer of ingested glucose and an important reservoir of body proteins, is intricately linked with homeostasis, and with important anabolic and catabolic functions, respectively. Herein, we provide a brief overview of how gut microbiota may influence muscle health and how various microbes may in turn be altered during certain muscle disease states. Specifically, we discuss recent experimental and clinical evidence in support for a role of gut-muscle crosstalk and include suggested underpinning molecular mechanisms that facilitate this crosstalk in health and diseased conditions. We end with a brief perspective on how exercise and pharmacological interventions may interface with the gut-muscle axis to improve muscle mass and function. |
| first_indexed | 2024-10-01T05:37:49Z |
| format | Journal Article |
| id | ntu-10356/168909 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:37:49Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1689092023-06-25T15:37:47Z Gut-muscle crosstalk. a perspective on influence of microbes on muscle function Chew, Weixuan Lim, Yen Peng Lim, Wee Shiong Chambers, Edward S. Frost, Gary Wong, Sunny Hei Ali, Yusuf Lee Kong Chian School of Medicine (LKCMedicine) Tan Tock Seng Hospital Science::Medicine Metabolite Sarcopenia Our gastrointestinal system functions to digest and absorb ingested food, but it is also home to trillions of microbes that change across time, nutrition, lifestyle, and disease conditions. Largely commensals, these microbes are gaining prominence with regards to how they collectively affect the function of important metabolic organs, from the adipose tissues to the endocrine pancreas to the skeletal muscle. Muscle, as the biggest utilizer of ingested glucose and an important reservoir of body proteins, is intricately linked with homeostasis, and with important anabolic and catabolic functions, respectively. Herein, we provide a brief overview of how gut microbiota may influence muscle health and how various microbes may in turn be altered during certain muscle disease states. Specifically, we discuss recent experimental and clinical evidence in support for a role of gut-muscle crosstalk and include suggested underpinning molecular mechanisms that facilitate this crosstalk in health and diseased conditions. We end with a brief perspective on how exercise and pharmacological interventions may interface with the gut-muscle axis to improve muscle mass and function. Ministry of Education (MOE) Nanyang Technological University Published version This work was supported by the Ministry of Education Singapore (MOE2018-T2-1-085 and MOE-T2EP30221-0003) (YA) and Tier 1 (2019-T1-001-059) (YA). This work is also partly supported by the LKC Medicine Healthcare Research Fund (Diabetes Research), established through the generous support of alumni of Nanyang Technological University, Singapore, the NTU Start Up Grant (021337-00001) (SW) and Wang Lee Wah Memorial Fund for the support of this work. 2023-06-22T04:45:05Z 2023-06-22T04:45:05Z 2022 Journal Article Chew, W., Lim, Y. P., Lim, W. S., Chambers, E. S., Frost, G., Wong, S. H. & Ali, Y. (2022). Gut-muscle crosstalk. a perspective on influence of microbes on muscle function. Frontiers in Medicine, 9, 1065365-. https://dx.doi.org/10.3389/fmed.2022.1065365 2296-858X https://hdl.handle.net/10356/168909 10.3389/fmed.2022.1065365 36698827 2-s2.0-85147007903 9 1065365 en MOE2018-T2-1-085 MOE-T2EP30221-0003 2019-T1-001-059 021337-00001 Frontiers in Medicine © 2023 Chew, Lim, Lim, Chambers, Frost, Wong and Ali. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf |
| spellingShingle | Science::Medicine Metabolite Sarcopenia Chew, Weixuan Lim, Yen Peng Lim, Wee Shiong Chambers, Edward S. Frost, Gary Wong, Sunny Hei Ali, Yusuf Gut-muscle crosstalk. a perspective on influence of microbes on muscle function |
| title | Gut-muscle crosstalk. a perspective on influence of microbes on muscle function |
| title_full | Gut-muscle crosstalk. a perspective on influence of microbes on muscle function |
| title_fullStr | Gut-muscle crosstalk. a perspective on influence of microbes on muscle function |
| title_full_unstemmed | Gut-muscle crosstalk. a perspective on influence of microbes on muscle function |
| title_short | Gut-muscle crosstalk. a perspective on influence of microbes on muscle function |
| title_sort | gut muscle crosstalk a perspective on influence of microbes on muscle function |
| topic | Science::Medicine Metabolite Sarcopenia |
| url | https://hdl.handle.net/10356/168909 |
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