Emerging regulatory mechanisms of noncoding RNAs in topologically associating domains
Topologically associating domains (TADs) are integral to spatial genome organization, instructing gene expression, and cell fate. Recently, several advances have uncovered roles for noncoding RNAs (ncRNAs) in the regulation of the form and function of mammalian TADs. Phase separation has also emerge...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://hdl.handle.net/10356/168913 |
| _version_ | 1826116957726834688 |
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| author | Yeo, Samuel Jianjie Ying, Chen Fullwood, Melissa Jane Tergaonkar, Vinay |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Yeo, Samuel Jianjie Ying, Chen Fullwood, Melissa Jane Tergaonkar, Vinay |
| author_sort | Yeo, Samuel Jianjie |
| collection | NTU |
| description | Topologically associating domains (TADs) are integral to spatial genome organization, instructing gene expression, and cell fate. Recently, several advances have uncovered roles for noncoding RNAs (ncRNAs) in the regulation of the form and function of mammalian TADs. Phase separation has also emerged as a potential arbiter of ncRNAs in the regulation of TADs. In this review we discuss the implications of these novel findings in relation to how ncRNAs might structurally and functionally regulate TADs from two perspectives: moderating loop extrusion through interactions with architectural proteins, and facilitating TAD phase separation. Additionally, we propose future studies and directions to investigate these phenomena. |
| first_indexed | 2024-10-01T04:19:55Z |
| format | Journal Article |
| id | ntu-10356/168913 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:19:55Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1689132023-07-31T15:32:12Z Emerging regulatory mechanisms of noncoding RNAs in topologically associating domains Yeo, Samuel Jianjie Ying, Chen Fullwood, Melissa Jane Tergaonkar, Vinay Lee Kong Chian School of Medicine (LKCMedicine) School of Biological Sciences Institute of Molecular Biology, A*STAR Science::Biological sciences Topologically Associating Domains Noncoding RNAs Topologically associating domains (TADs) are integral to spatial genome organization, instructing gene expression, and cell fate. Recently, several advances have uncovered roles for noncoding RNAs (ncRNAs) in the regulation of the form and function of mammalian TADs. Phase separation has also emerged as a potential arbiter of ncRNAs in the regulation of TADs. In this review we discuss the implications of these novel findings in relation to how ncRNAs might structurally and functionally regulate TADs from two perspectives: moderating loop extrusion through interactions with architectural proteins, and facilitating TAD phase separation. Additionally, we propose future studies and directions to investigate these phenomena. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) National Research Foundation (NRF) Submitted/Accepted version This research is supported by the Agency for Science, Technology and Research (A*STAR) and the National Research Foundation (NRF) Singapore (NRF-CRP26-2021-0001), the Ministry of Education. This research is also supported by the National Research Foundation Singapore and the Singapore Ministry of Education (MOE) through an Academic Research Fund Tier 1 grant (RG86/21) and an Academic Research Fund Tier 2 grant (MOE-T2EP30120-0009) both awarded to M.J.F. under its Research Centres of Excellence initiative. 2023-06-22T04:55:49Z 2023-06-22T04:55:49Z 2023 Journal Article Yeo, S. J., Ying, C., Fullwood, M. J. & Tergaonkar, V. (2023). Emerging regulatory mechanisms of noncoding RNAs in topologically associating domains. Trends in Genetics, 39(3), 217-232. https://dx.doi.org/10.1016/j.tig.2022.12.003 0168-9525 https://hdl.handle.net/10356/168913 10.1016/j.tig.2022.12.003 36642680 2-s2.0-85146334453 3 39 217 232 en NRF-CRP26-2021-0001 RG86/21 MOE-T2EP30120-0009 Trends in Genetics © 2022 Elsevier Ltd. All rights reserved. This paper was published in Trends in Genetics and is made available with permission of Elsevier Ltd. application/pdf |
| spellingShingle | Science::Biological sciences Topologically Associating Domains Noncoding RNAs Yeo, Samuel Jianjie Ying, Chen Fullwood, Melissa Jane Tergaonkar, Vinay Emerging regulatory mechanisms of noncoding RNAs in topologically associating domains |
| title | Emerging regulatory mechanisms of noncoding RNAs in topologically associating domains |
| title_full | Emerging regulatory mechanisms of noncoding RNAs in topologically associating domains |
| title_fullStr | Emerging regulatory mechanisms of noncoding RNAs in topologically associating domains |
| title_full_unstemmed | Emerging regulatory mechanisms of noncoding RNAs in topologically associating domains |
| title_short | Emerging regulatory mechanisms of noncoding RNAs in topologically associating domains |
| title_sort | emerging regulatory mechanisms of noncoding rnas in topologically associating domains |
| topic | Science::Biological sciences Topologically Associating Domains Noncoding RNAs |
| url | https://hdl.handle.net/10356/168913 |
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