A novel microparticle size sorting technology based on sheath flow stable expansion regimes
Previously we have originally reported and experimentally explored the stable expansion phenomenon of sheath flow in straight microchannels. The stable expansion phenomenon differs from the focused stable thread and diffusion, which are expected to appear based on current understanding. It happens w...
| Main Authors: | , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/169162 |
| _version_ | 1826115423328796672 |
|---|---|
| author | Zhang, Boran Zhao, Wenhan Yuan, Dan Wang, Tiao Wu, Wenshuai |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Zhang, Boran Zhao, Wenhan Yuan, Dan Wang, Tiao Wu, Wenshuai |
| author_sort | Zhang, Boran |
| collection | NTU |
| description | Previously we have originally reported and experimentally explored the stable expansion phenomenon of sheath flow in straight microchannels. The stable expansion phenomenon differs from the focused stable thread and diffusion, which are expected to appear based on current understanding. It happens within a specific range of Reynolds numbers in microchannels with specific aspect ratios. However, the mechanism insight and potential applications remained poorly understood. In this study, a comprehensive numerical model, involving laminar flow, diluted species transportation, and particle tracing, was established to provide a global transparent insight. Based on the simulation results, the root cause and mechanism of the stable expansion phenomenon were revealed as a dumbbell-shape deformation of the buffer-sample-buffer interface. In addition, a microparticle size sorting application based on these findings was proposed and conducted in both simulation and experiment. The results showed that 1 and 15 μm microparticles can be totally separated with nearly 100% purity. According to the advantages and potentials of this technique, it can be promising to approach a label-free microparticle sorting with a high throughput manner. |
| first_indexed | 2024-10-01T03:54:54Z |
| format | Journal Article |
| id | ntu-10356/169162 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:54:54Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1691622023-07-07T15:39:11Z A novel microparticle size sorting technology based on sheath flow stable expansion regimes Zhang, Boran Zhao, Wenhan Yuan, Dan Wang, Tiao Wu, Wenshuai School of Electrical and Electronic Engineering Engineering::Electrical and electronic engineering Expansion Regimes Micro Particles Previously we have originally reported and experimentally explored the stable expansion phenomenon of sheath flow in straight microchannels. The stable expansion phenomenon differs from the focused stable thread and diffusion, which are expected to appear based on current understanding. It happens within a specific range of Reynolds numbers in microchannels with specific aspect ratios. However, the mechanism insight and potential applications remained poorly understood. In this study, a comprehensive numerical model, involving laminar flow, diluted species transportation, and particle tracing, was established to provide a global transparent insight. Based on the simulation results, the root cause and mechanism of the stable expansion phenomenon were revealed as a dumbbell-shape deformation of the buffer-sample-buffer interface. In addition, a microparticle size sorting application based on these findings was proposed and conducted in both simulation and experiment. The results showed that 1 and 15 μm microparticles can be totally separated with nearly 100% purity. According to the advantages and potentials of this technique, it can be promising to approach a label-free microparticle sorting with a high throughput manner. Published version This research work was supported by the National Natural Science Foundation of China (Grant No. 61827827). 2023-07-04T05:04:58Z 2023-07-04T05:04:58Z 2023 Journal Article Zhang, B., Zhao, W., Yuan, D., Wang, T. & Wu, W. (2023). A novel microparticle size sorting technology based on sheath flow stable expansion regimes. Physics of Fluids, 35(5), 052018-1-052018-7. https://dx.doi.org/10.1063/5.0152581 1070-6631 https://hdl.handle.net/10356/169162 10.1063/5.0152581 2-s2.0-85160866500 5 35 052018-1 052018-7 en Physics of Fluids © 2023 Author(s). Published under an exclusive license by AIP Publishing. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the author(s) and AIP Publishing. This article appeared in Zhang, B., Zhao, W., Yuan, D., Wang, T. & Wu, W. (2023). A novel microparticle size sorting technology based on sheath flow stable expansion regimes. Physics of Fluids, 35(5), 052018-1 - 052018-7 and may be found at https://doi.org/10.1063/5.0152581 application/pdf |
| spellingShingle | Engineering::Electrical and electronic engineering Expansion Regimes Micro Particles Zhang, Boran Zhao, Wenhan Yuan, Dan Wang, Tiao Wu, Wenshuai A novel microparticle size sorting technology based on sheath flow stable expansion regimes |
| title | A novel microparticle size sorting technology based on sheath flow stable expansion regimes |
| title_full | A novel microparticle size sorting technology based on sheath flow stable expansion regimes |
| title_fullStr | A novel microparticle size sorting technology based on sheath flow stable expansion regimes |
| title_full_unstemmed | A novel microparticle size sorting technology based on sheath flow stable expansion regimes |
| title_short | A novel microparticle size sorting technology based on sheath flow stable expansion regimes |
| title_sort | novel microparticle size sorting technology based on sheath flow stable expansion regimes |
| topic | Engineering::Electrical and electronic engineering Expansion Regimes Micro Particles |
| url | https://hdl.handle.net/10356/169162 |
| work_keys_str_mv | AT zhangboran anovelmicroparticlesizesortingtechnologybasedonsheathflowstableexpansionregimes AT zhaowenhan anovelmicroparticlesizesortingtechnologybasedonsheathflowstableexpansionregimes AT yuandan anovelmicroparticlesizesortingtechnologybasedonsheathflowstableexpansionregimes AT wangtiao anovelmicroparticlesizesortingtechnologybasedonsheathflowstableexpansionregimes AT wuwenshuai anovelmicroparticlesizesortingtechnologybasedonsheathflowstableexpansionregimes AT zhangboran novelmicroparticlesizesortingtechnologybasedonsheathflowstableexpansionregimes AT zhaowenhan novelmicroparticlesizesortingtechnologybasedonsheathflowstableexpansionregimes AT yuandan novelmicroparticlesizesortingtechnologybasedonsheathflowstableexpansionregimes AT wangtiao novelmicroparticlesizesortingtechnologybasedonsheathflowstableexpansionregimes AT wuwenshuai novelmicroparticlesizesortingtechnologybasedonsheathflowstableexpansionregimes |