Age-related changes in episodic processing of scenes: a functional activation and connectivity study
The posterior-to-anterior shift in aging (PASA) effect is seen as a compensatory model that enables older adults to meet increased cognitive demands to perform comparably as their young counterparts. However, empirical support for the PASA effect investigating age-related changes in the inferior fro...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://hdl.handle.net/10356/169164 |
| _version_ | 1811683848016101376 |
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| author | Miyakoshi, Makoto Archer, Josephine Astrid Wu, Chiao-Yi Nakai, Toshiharu Chen, Annabel Shen-Hsing |
| author2 | School of Social Sciences |
| author_facet | School of Social Sciences Miyakoshi, Makoto Archer, Josephine Astrid Wu, Chiao-Yi Nakai, Toshiharu Chen, Annabel Shen-Hsing |
| author_sort | Miyakoshi, Makoto |
| collection | NTU |
| description | The posterior-to-anterior shift in aging (PASA) effect is seen as a compensatory model that enables older adults to meet increased cognitive demands to perform comparably as their young counterparts. However, empirical support for the PASA effect investigating age-related changes in the inferior frontal gyrus (IFG), hippocampus, and parahippocampus has yet to be established. 33 older adults and 48 young adults were administered tasks sensitive to novelty and relational processing of indoor/outdoor scenes in a 3-Tesla MRI scanner. Functional activation and connectivity analyses were applied to examine the age-related changes on the IFG, hippocampus, and parahippocampus among low/high-performing older adults and young adults. Significant parahippocampal activation was generally found in both older (high-performing) and young adults for novelty and relational processing of scenes. Younger adults had significantly greater IFG and parahippocampal activation than older adults, and greater parahippocampal activation compared to low-performing older adults for relational processing-providing partial support for the PASA model. Observations of significant functional connectivity within the medial temporal lobe and greater negative left IFG-right hippocampus/parahippocampus functional connectivity for young compared to low-performing older adults for relational processing also supports the PASA effect partially. |
| first_indexed | 2024-10-01T04:19:15Z |
| format | Journal Article |
| id | ntu-10356/169164 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:19:15Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1691642023-07-09T15:30:23Z Age-related changes in episodic processing of scenes: a functional activation and connectivity study Miyakoshi, Makoto Archer, Josephine Astrid Wu, Chiao-Yi Nakai, Toshiharu Chen, Annabel Shen-Hsing School of Social Sciences Lee Kong Chian School of Medicine (LKCMedicine) Centre for Research in Child Development, NIE Centre for Research and Development in Learning (CRADLE) Science::Medicine Episodic Processing Inferior Frontal Gyrus The posterior-to-anterior shift in aging (PASA) effect is seen as a compensatory model that enables older adults to meet increased cognitive demands to perform comparably as their young counterparts. However, empirical support for the PASA effect investigating age-related changes in the inferior frontal gyrus (IFG), hippocampus, and parahippocampus has yet to be established. 33 older adults and 48 young adults were administered tasks sensitive to novelty and relational processing of indoor/outdoor scenes in a 3-Tesla MRI scanner. Functional activation and connectivity analyses were applied to examine the age-related changes on the IFG, hippocampus, and parahippocampus among low/high-performing older adults and young adults. Significant parahippocampal activation was generally found in both older (high-performing) and young adults for novelty and relational processing of scenes. Younger adults had significantly greater IFG and parahippocampal activation than older adults, and greater parahippocampal activation compared to low-performing older adults for relational processing-providing partial support for the PASA model. Observations of significant functional connectivity within the medial temporal lobe and greater negative left IFG-right hippocampus/parahippocampus functional connectivity for young compared to low-performing older adults for relational processing also supports the PASA effect partially. Ministry of Education (MOE) Published version This research is supported by the Ministry of Education, MOE2019-T2-1-019 (S), Singapore and Japan Society for the Promotion of Science (JSPS) under Grants-in-Aid for Scientific Research [KAKENHI #15H03104 and 19H04025]. 2023-07-04T05:46:23Z 2023-07-04T05:46:23Z 2023 Journal Article Miyakoshi, M., Archer, J. A., Wu, C., Nakai, T. & Chen, A. S. (2023). Age-related changes in episodic processing of scenes: a functional activation and connectivity study. Sensors, 23(8), 4107-. https://dx.doi.org/10.3390/s23084107 1424-8220 https://hdl.handle.net/10356/169164 10.3390/s23084107 37112449 2-s2.0-85153929526 8 23 4107 en MOE2019-T2-1-019 (S) Sensors © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). application/pdf |
| spellingShingle | Science::Medicine Episodic Processing Inferior Frontal Gyrus Miyakoshi, Makoto Archer, Josephine Astrid Wu, Chiao-Yi Nakai, Toshiharu Chen, Annabel Shen-Hsing Age-related changes in episodic processing of scenes: a functional activation and connectivity study |
| title | Age-related changes in episodic processing of scenes: a functional activation and connectivity study |
| title_full | Age-related changes in episodic processing of scenes: a functional activation and connectivity study |
| title_fullStr | Age-related changes in episodic processing of scenes: a functional activation and connectivity study |
| title_full_unstemmed | Age-related changes in episodic processing of scenes: a functional activation and connectivity study |
| title_short | Age-related changes in episodic processing of scenes: a functional activation and connectivity study |
| title_sort | age related changes in episodic processing of scenes a functional activation and connectivity study |
| topic | Science::Medicine Episodic Processing Inferior Frontal Gyrus |
| url | https://hdl.handle.net/10356/169164 |
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