Low neighborhood deprivation buffers against hippocampal neurodegeneration, white matter hyperintensities, and poorer cognition

There is increasing recognition that socioeconomic inequalities contribute to disparities in brain and cognitive health in older adults. However, whether neighborhood socioeconomic status (SES) buffers individuals with low individual SES against neurodegeneration, cerebrovascular disease, and poorer...

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Main Authors: Tan, Chin Hong, Tan, Jacinth J. X.
Other Authors: School of Social Sciences
Format: Journal Article
Language:English
Published: 2023
Subjects:
Online Access:https://hdl.handle.net/10356/169332
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author Tan, Chin Hong
Tan, Jacinth J. X.
author2 School of Social Sciences
author_facet School of Social Sciences
Tan, Chin Hong
Tan, Jacinth J. X.
author_sort Tan, Chin Hong
collection NTU
description There is increasing recognition that socioeconomic inequalities contribute to disparities in brain and cognitive health in older adults. However, whether neighborhood socioeconomic status (SES) buffers individuals with low individual SES against neurodegeneration, cerebrovascular disease, and poorer cognitive function is not well understood. Here, we evaluated whether neighborhood deprivation (Townsend deprivation index) interacted with individual SES (composite household income and education levels) on hippocampus volume, regional cortical thickness, white matter hyperintensities, and cognition in 19,638 individuals (mean age = 54.8) from the UK Biobank. We found that individuals with low individual SES had the smallest hippocampal volumes, greatest white matter hyperintensity burden, and poorest cognition if they were living in high deprivation neighborhoods but that these deleterious effects on brain and cognitive function were attenuated if they were living in low deprivation neighborhoods (p for interactions < .05). While neighborhood deprivation did not interact with individual SES to influence regional cortical thickness, higher neighborhood deprivation was independently associated with lower cortical thickness in 16 regions (false discovery rate q < .05). Across multiple brain indices and cognitive function analyses, we found converging evidence suggesting that low neighborhood deprivation may have a neuroprotective effect against neurodegeneration, cerebrovascular pathology, and cognitive impairment, particularly in vulnerable individuals with low household income and education levels.
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spelling ntu-10356/1693322023-07-18T05:12:04Z Low neighborhood deprivation buffers against hippocampal neurodegeneration, white matter hyperintensities, and poorer cognition Tan, Chin Hong Tan, Jacinth J. X. School of Social Sciences Lee Kong Chian School of Medicine (LKCMedicine) Social sciences::Psychology Hippocampus Neurodegeneration There is increasing recognition that socioeconomic inequalities contribute to disparities in brain and cognitive health in older adults. However, whether neighborhood socioeconomic status (SES) buffers individuals with low individual SES against neurodegeneration, cerebrovascular disease, and poorer cognitive function is not well understood. Here, we evaluated whether neighborhood deprivation (Townsend deprivation index) interacted with individual SES (composite household income and education levels) on hippocampus volume, regional cortical thickness, white matter hyperintensities, and cognition in 19,638 individuals (mean age = 54.8) from the UK Biobank. We found that individuals with low individual SES had the smallest hippocampal volumes, greatest white matter hyperintensity burden, and poorest cognition if they were living in high deprivation neighborhoods but that these deleterious effects on brain and cognitive function were attenuated if they were living in low deprivation neighborhoods (p for interactions < .05). While neighborhood deprivation did not interact with individual SES to influence regional cortical thickness, higher neighborhood deprivation was independently associated with lower cortical thickness in 16 regions (false discovery rate q < .05). Across multiple brain indices and cognitive function analyses, we found converging evidence suggesting that low neighborhood deprivation may have a neuroprotective effect against neurodegeneration, cerebrovascular pathology, and cognitive impairment, particularly in vulnerable individuals with low household income and education levels. Ministry of Education (MOE) Nanyang Technological University Submitted/Accepted version This study was supported by Nanyang Technological University, Singapore Start-Up Grant M40824100 and MOE AcRF Tier 1 M4012193. 2023-07-13T02:35:04Z 2023-07-13T02:35:04Z 2023 Journal Article Tan, C. H. & Tan, J. J. X. (2023). Low neighborhood deprivation buffers against hippocampal neurodegeneration, white matter hyperintensities, and poorer cognition. GeroScience. https://dx.doi.org/10.1007/s11357-023-00780-y 2509-2715 https://hdl.handle.net/10356/169332 10.1007/s11357-023-00780-y 37004594 2-s2.0-85151472452 en M40824100 M4012193 GeroScience © 2023 The Author(s), under exclusive licence to American Aging Association. All righs reserved. This version of the article has been accepted for publication, after peer review and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11357-023-00780-y. application/pdf
spellingShingle Social sciences::Psychology
Hippocampus
Neurodegeneration
Tan, Chin Hong
Tan, Jacinth J. X.
Low neighborhood deprivation buffers against hippocampal neurodegeneration, white matter hyperintensities, and poorer cognition
title Low neighborhood deprivation buffers against hippocampal neurodegeneration, white matter hyperintensities, and poorer cognition
title_full Low neighborhood deprivation buffers against hippocampal neurodegeneration, white matter hyperintensities, and poorer cognition
title_fullStr Low neighborhood deprivation buffers against hippocampal neurodegeneration, white matter hyperintensities, and poorer cognition
title_full_unstemmed Low neighborhood deprivation buffers against hippocampal neurodegeneration, white matter hyperintensities, and poorer cognition
title_short Low neighborhood deprivation buffers against hippocampal neurodegeneration, white matter hyperintensities, and poorer cognition
title_sort low neighborhood deprivation buffers against hippocampal neurodegeneration white matter hyperintensities and poorer cognition
topic Social sciences::Psychology
Hippocampus
Neurodegeneration
url https://hdl.handle.net/10356/169332
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