Impact of cognitive impairments on health-related quality of life in schizophrenia
The impact of cognitive impairments on the health-related quality of life (HRQoL) in individuals with schizophrenia is unclear. The aim of this study was to examine the association between cognitive impairments and HRQoL in individuals with schizophrenia. A total of 609 individuals with schizophreni...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2023
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| Online Access: | https://hdl.handle.net/10356/169528 |
| _version_ | 1811694447124021248 |
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| author | Rekhi, Gurpreet Saw, Young Ern Lim, Keane Keefe, Richard S. E. Lee, Jimmy |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Rekhi, Gurpreet Saw, Young Ern Lim, Keane Keefe, Richard S. E. Lee, Jimmy |
| author_sort | Rekhi, Gurpreet |
| collection | NTU |
| description | The impact of cognitive impairments on the health-related quality of life (HRQoL) in individuals with schizophrenia is unclear. The aim of this study was to examine the association between cognitive impairments and HRQoL in individuals with schizophrenia. A total of 609 individuals with schizophrenia were assessed on the Positive and Negative Syndrome Scale (PANSS) and a neurocognitive battery which comprised of the Wechsler Abbreviated Scale of Intelligence matrix reasoning, the Benton Judgment of Line Orientation Test, Continuous Performance Tests-Identical Pairs, and the Brief Assessment of Cognition in Schizophrenia. A cognitive factor g was derived from the neurocognitive battery. EuroQol five-dimensional (EQ-5D-5L) utility scores were derived from PANSS scores via a previously validated algorithm and used as a measure of HRQoL. Hierarchical multiple regression was conducted to examine the association between cognitive factor g and the EQ-5D-5L. Cognitive factor g (β = 0.189, t = 4.956, p < 0.001) was found to be significantly associated with EQ-5D-5L scores. Age (β = -0.258, t = -6.776, p < 0.001), sex (β = 0.081, t = 2.117, p = 0.035), and being employed (β = 0.091, t = 2.317, p = 0.021) were also significant predictors of EQ-5D-5L. Our results add to the extant literature on the burden cognitive impairments exact in individuals with schizophrenia. More research is needed to develop effective interventions for cognitive impairments in schizophrenia. |
| first_indexed | 2024-10-01T07:07:43Z |
| format | Journal Article |
| id | ntu-10356/169528 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:07:43Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1695282023-07-23T15:38:19Z Impact of cognitive impairments on health-related quality of life in schizophrenia Rekhi, Gurpreet Saw, Young Ern Lim, Keane Keefe, Richard S. E. Lee, Jimmy Lee Kong Chian School of Medicine (LKCMedicine) Institute of Mental Health Science::Medicine Cognitive Impairments Health-Related Quality of Life The impact of cognitive impairments on the health-related quality of life (HRQoL) in individuals with schizophrenia is unclear. The aim of this study was to examine the association between cognitive impairments and HRQoL in individuals with schizophrenia. A total of 609 individuals with schizophrenia were assessed on the Positive and Negative Syndrome Scale (PANSS) and a neurocognitive battery which comprised of the Wechsler Abbreviated Scale of Intelligence matrix reasoning, the Benton Judgment of Line Orientation Test, Continuous Performance Tests-Identical Pairs, and the Brief Assessment of Cognition in Schizophrenia. A cognitive factor g was derived from the neurocognitive battery. EuroQol five-dimensional (EQ-5D-5L) utility scores were derived from PANSS scores via a previously validated algorithm and used as a measure of HRQoL. Hierarchical multiple regression was conducted to examine the association between cognitive factor g and the EQ-5D-5L. Cognitive factor g (β = 0.189, t = 4.956, p < 0.001) was found to be significantly associated with EQ-5D-5L scores. Age (β = -0.258, t = -6.776, p < 0.001), sex (β = 0.081, t = 2.117, p = 0.035), and being employed (β = 0.091, t = 2.317, p = 0.021) were also significant predictors of EQ-5D-5L. Our results add to the extant literature on the burden cognitive impairments exact in individuals with schizophrenia. More research is needed to develop effective interventions for cognitive impairments in schizophrenia. National Medical Research Council (NMRC) National Research Foundation (NRF) Published version This research was funded by the National Research Foundation of Singapore under the National Medical Research Council Translational and Clinical Research Flagship Programme, Grant No.: NMRC/TCR/003/2008. 2023-07-21T08:18:12Z 2023-07-21T08:18:12Z 2023 Journal Article Rekhi, G., Saw, Y. E., Lim, K., Keefe, R. S. E. & Lee, J. (2023). Impact of cognitive impairments on health-related quality of life in schizophrenia. Brain Sciences, 13(2), 215-. https://dx.doi.org/10.3390/brainsci13020215 2076-3425 https://hdl.handle.net/10356/169528 10.3390/brainsci13020215 36831758 2-s2.0-85148865374 2 13 215 en NMRC/TCR/003/2008 Brain Sciences © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). application/pdf |
| spellingShingle | Science::Medicine Cognitive Impairments Health-Related Quality of Life Rekhi, Gurpreet Saw, Young Ern Lim, Keane Keefe, Richard S. E. Lee, Jimmy Impact of cognitive impairments on health-related quality of life in schizophrenia |
| title | Impact of cognitive impairments on health-related quality of life in schizophrenia |
| title_full | Impact of cognitive impairments on health-related quality of life in schizophrenia |
| title_fullStr | Impact of cognitive impairments on health-related quality of life in schizophrenia |
| title_full_unstemmed | Impact of cognitive impairments on health-related quality of life in schizophrenia |
| title_short | Impact of cognitive impairments on health-related quality of life in schizophrenia |
| title_sort | impact of cognitive impairments on health related quality of life in schizophrenia |
| topic | Science::Medicine Cognitive Impairments Health-Related Quality of Life |
| url | https://hdl.handle.net/10356/169528 |
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