A concise synthesis of pyrrole-based drug candidates from α-hydroxyketones, 3-oxobutanenitrile, and anilines
A simple and concise three-component synthesis of a key pyrrole framework was developed from the reaction between α-hydroxyketones, oxoacetonitriles, and anilines. The synthesis was used to obtain several pyrrole-based drug candidates, including COX-2 selective NSAID, antituberculosis lead candidate...
Main Authors: | Xia, Mengxin, Santoso, Mardi, Moussa, Ziad, Judeh, Zaher M. A. |
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Other Authors: | School of Chemistry, Chemical Engineering and Biotechnology |
Format: | Journal Article |
Language: | English |
Published: |
2023
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/169534 |
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