Differentiating people with schizophrenia from healthy controls in a developing country: an evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool
Introduction: This study aimed to evaluate portable functional near-infrared spectroscopy (fNIRS) device as an adjunct diagnostic tool in Vietnam to assess hemodynamics when people with schizophrenia and healthy controls performed cognitive tasks. Methods: One hundred fifty-seven participants were...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/169709 |
| _version_ | 1824454404045012992 |
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| author | Tran, Bach Xuan Nguyen, Tham Thi Boyer, Laurent Fond, Guillaume Auquier, Pascal Nguyen, Hao Si Anh Tran, Ha Thi Nhi Nguyen, Hung Manh Choi, Jongkwan Le, Huong Thi Latkin, Carl A. Nathan, Kalpana Isabel Husain, Syeda F. McIntyre, Roger S. Ho, Cyrus S. H. Zhang, Melvyn Ho, Roger C. M. |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Tran, Bach Xuan Nguyen, Tham Thi Boyer, Laurent Fond, Guillaume Auquier, Pascal Nguyen, Hao Si Anh Tran, Ha Thi Nhi Nguyen, Hung Manh Choi, Jongkwan Le, Huong Thi Latkin, Carl A. Nathan, Kalpana Isabel Husain, Syeda F. McIntyre, Roger S. Ho, Cyrus S. H. Zhang, Melvyn Ho, Roger C. M. |
| author_sort | Tran, Bach Xuan |
| collection | NTU |
| description | Introduction: This study aimed to evaluate portable functional near-infrared spectroscopy (fNIRS) device as an adjunct diagnostic tool in Vietnam to assess hemodynamics when people with schizophrenia and healthy controls performed cognitive tasks.
Methods: One hundred fifty-seven participants were divided into schizophrenia (n = 110) and healthy controls group (n = 47), which were recruited by match of age, and gender. Hemodynamic responses in the frontal cortex were monitored with a 48-channel portable device during the Stroop Color-Word Test (SCWT) and Verbal Fluency Test (VFT). General linear model compared the differences in oxyhemoglobin (HbO2) levels between the two groups. The Receiver Operating Characteristic (ROC) graph was generated for each neuroanatomical area.
Results: People with schizophrenia did not show significant activation in the frontal lobe during the SCWT and VFT as compared to pre-task. During the VFT, the area under the ROC curve of the bilateral dorsolateral prefrontal cortex, bilateral orbitofrontal cortex, bilateral frontopolar prefrontal cortex, and bilateral ventrolateral prefrontal cortex were greater than 0.7 (p < 0.001). The area under the ROC curve (AUC) for the right orbitofrontal cortex was maximal during the VFT (AUC = 0.802, 95%CI = 0.731–0.872). The Youden’s index reached a peak (0.57) at the optimal cut-point value (HbO2 cutoff <0.209 μmol/ml for schizophrenia) in which the sensitivity was 85%; specificity was 72%; positive predictive value (PPV) was 0.88; negative predictive value (NPV) was 0.68 and correct classification rate was 76%.
Discussion: Assessing hemodynamics during VFT by portable fNIRS offers the potential as an adjunct diagnostic tool for schizophrenia in developing countries. |
| first_indexed | 2025-02-19T03:21:46Z |
| format | Journal Article |
| id | ntu-10356/169709 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:21:46Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1697092023-08-06T15:38:11Z Differentiating people with schizophrenia from healthy controls in a developing country: an evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool Tran, Bach Xuan Nguyen, Tham Thi Boyer, Laurent Fond, Guillaume Auquier, Pascal Nguyen, Hao Si Anh Tran, Ha Thi Nhi Nguyen, Hung Manh Choi, Jongkwan Le, Huong Thi Latkin, Carl A. Nathan, Kalpana Isabel Husain, Syeda F. McIntyre, Roger S. Ho, Cyrus S. H. Zhang, Melvyn Ho, Roger C. M. Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Spectrometry Cortical Hemodynamic Response Introduction: This study aimed to evaluate portable functional near-infrared spectroscopy (fNIRS) device as an adjunct diagnostic tool in Vietnam to assess hemodynamics when people with schizophrenia and healthy controls performed cognitive tasks. Methods: One hundred fifty-seven participants were divided into schizophrenia (n = 110) and healthy controls group (n = 47), which were recruited by match of age, and gender. Hemodynamic responses in the frontal cortex were monitored with a 48-channel portable device during the Stroop Color-Word Test (SCWT) and Verbal Fluency Test (VFT). General linear model compared the differences in oxyhemoglobin (HbO2) levels between the two groups. The Receiver Operating Characteristic (ROC) graph was generated for each neuroanatomical area. Results: People with schizophrenia did not show significant activation in the frontal lobe during the SCWT and VFT as compared to pre-task. During the VFT, the area under the ROC curve of the bilateral dorsolateral prefrontal cortex, bilateral orbitofrontal cortex, bilateral frontopolar prefrontal cortex, and bilateral ventrolateral prefrontal cortex were greater than 0.7 (p < 0.001). The area under the ROC curve (AUC) for the right orbitofrontal cortex was maximal during the VFT (AUC = 0.802, 95%CI = 0.731–0.872). The Youden’s index reached a peak (0.57) at the optimal cut-point value (HbO2 cutoff <0.209 μmol/ml for schizophrenia) in which the sensitivity was 85%; specificity was 72%; positive predictive value (PPV) was 0.88; negative predictive value (NPV) was 0.68 and correct classification rate was 76%. Discussion: Assessing hemodynamics during VFT by portable fNIRS offers the potential as an adjunct diagnostic tool for schizophrenia in developing countries. Published version This study received funding from the Gia Lam Urban Development and Investment Company Limited, Vingroup, Vingroup Innovation Foundation (VINIF) (Grant No. VINIF.2019.DA14), NUS Department of Psychological Medicine (R177-000-100-001/R-177-000-003-001), and NUS iHeathtech Other Operating Expenses (R-722-000-004-731). 2023-08-01T00:39:00Z 2023-08-01T00:39:00Z 2023 Journal Article Tran, B. X., Nguyen, T. T., Boyer, L., Fond, G., Auquier, P., Nguyen, H. S. A., Tran, H. T. N., Nguyen, H. M., Choi, J., Le, H. T., Latkin, C. A., Nathan, K. I., Husain, S. F., McIntyre, R. S., Ho, C. S. H., Zhang, M. & Ho, R. C. M. (2023). Differentiating people with schizophrenia from healthy controls in a developing country: an evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool. Frontiers in Psychiatry, 14, 1061284-. https://dx.doi.org/10.3389/fpsyt.2023.1061284 1664-0640 https://hdl.handle.net/10356/169709 10.3389/fpsyt.2023.1061284 36778640 2-s2.0-85147779547 14 1061284 en VINIF.2019.DA14 R177-000-100-001 R-177-000-003-001 R-722-000-004-731 Frontiers in Psychiatry © 2023 Tran, Nguyen, Boyer, Fond, Auquier, Nguyen, Tran, Nguyen, Choi, Le, Latkin, Nathan, Husain, McIntyre, Ho, Zhang and Ho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf |
| spellingShingle | Science::Medicine Spectrometry Cortical Hemodynamic Response Tran, Bach Xuan Nguyen, Tham Thi Boyer, Laurent Fond, Guillaume Auquier, Pascal Nguyen, Hao Si Anh Tran, Ha Thi Nhi Nguyen, Hung Manh Choi, Jongkwan Le, Huong Thi Latkin, Carl A. Nathan, Kalpana Isabel Husain, Syeda F. McIntyre, Roger S. Ho, Cyrus S. H. Zhang, Melvyn Ho, Roger C. M. Differentiating people with schizophrenia from healthy controls in a developing country: an evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool |
| title | Differentiating people with schizophrenia from healthy controls in a developing country: an evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool |
| title_full | Differentiating people with schizophrenia from healthy controls in a developing country: an evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool |
| title_fullStr | Differentiating people with schizophrenia from healthy controls in a developing country: an evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool |
| title_full_unstemmed | Differentiating people with schizophrenia from healthy controls in a developing country: an evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool |
| title_short | Differentiating people with schizophrenia from healthy controls in a developing country: an evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool |
| title_sort | differentiating people with schizophrenia from healthy controls in a developing country an evaluation of portable functional near infrared spectroscopy fnirs as an adjunct diagnostic tool |
| topic | Science::Medicine Spectrometry Cortical Hemodynamic Response |
| url | https://hdl.handle.net/10356/169709 |
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