Plant-derived extracellular vesicles: recent advancements and current challenges on their use for biomedical applications
Extracellular vesicles (EVs) represent a diverse class of lipid bilayer membrane vesicles released by both animal and plant cells. These ubiquitous vesicles are involved in intercellular communication and transport of various biological cargos, including proteins, lipids, and nucleic acids. In recen...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://hdl.handle.net/10356/169739 |
| _version_ | 1826114748684435456 |
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| author | Lian, Meredith Qikai Chng, Wei Heng Liang, Jeremy Yeo, Hui Qing Lee, Choon Keong Belaid, Mona Tollemeto, Matteo Wacker, Matthias Gerhard Czarny, Bertrand Pastorin, Giorgia |
| author2 | School of Materials Science and Engineering |
| author_facet | School of Materials Science and Engineering Lian, Meredith Qikai Chng, Wei Heng Liang, Jeremy Yeo, Hui Qing Lee, Choon Keong Belaid, Mona Tollemeto, Matteo Wacker, Matthias Gerhard Czarny, Bertrand Pastorin, Giorgia |
| author_sort | Lian, Meredith Qikai |
| collection | NTU |
| description | Extracellular vesicles (EVs) represent a diverse class of lipid bilayer membrane vesicles released by both animal and plant cells. These ubiquitous vesicles are involved in intercellular communication and transport of various biological cargos, including proteins, lipids, and nucleic acids. In recent years, interest in plant-derived EVs has increased tremendously, as they serve as a scalable and sustainable alternative to EVs derived from mammalian sources. In vitro and in vivo findings have demonstrated that these plant-derived vesicles (PDVs) possess intrinsic therapeutic activities that can potentially treat diseases and improve human health. In addition, PDVs can also act as efficient and biocompatible drug carriers. While preclinical studies have shown promising results, there are still several challenges and knowledge gaps that have to be addressed for the successful translation of PDVs into clinical applications, especially in view of the lack of standardised protocols for material handling and PDV isolation from various plant sources. This review provides the readers with a quick overview of the current understanding and research on PDVs, critically analysing the current challenges and highlighting the immense potential of PDVs as a novel class of therapeutics to treat human diseases. It is expected that this work will guide scientists to address the knowledge gaps currently associated with PDVs and promote new advances in plant-based therapeutic solutions. |
| first_indexed | 2024-10-01T03:44:13Z |
| format | Journal Article |
| id | ntu-10356/169739 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:44:13Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1697392023-08-04T15:45:37Z Plant-derived extracellular vesicles: recent advancements and current challenges on their use for biomedical applications Lian, Meredith Qikai Chng, Wei Heng Liang, Jeremy Yeo, Hui Qing Lee, Choon Keong Belaid, Mona Tollemeto, Matteo Wacker, Matthias Gerhard Czarny, Bertrand Pastorin, Giorgia School of Materials Science and Engineering Engineering::Materials Plant-Derived Extracellular Vesicles Plant-Derived Nanoparticles Extracellular vesicles (EVs) represent a diverse class of lipid bilayer membrane vesicles released by both animal and plant cells. These ubiquitous vesicles are involved in intercellular communication and transport of various biological cargos, including proteins, lipids, and nucleic acids. In recent years, interest in plant-derived EVs has increased tremendously, as they serve as a scalable and sustainable alternative to EVs derived from mammalian sources. In vitro and in vivo findings have demonstrated that these plant-derived vesicles (PDVs) possess intrinsic therapeutic activities that can potentially treat diseases and improve human health. In addition, PDVs can also act as efficient and biocompatible drug carriers. While preclinical studies have shown promising results, there are still several challenges and knowledge gaps that have to be addressed for the successful translation of PDVs into clinical applications, especially in view of the lack of standardised protocols for material handling and PDV isolation from various plant sources. This review provides the readers with a quick overview of the current understanding and research on PDVs, critically analysing the current challenges and highlighting the immense potential of PDVs as a novel class of therapeutics to treat human diseases. It is expected that this work will guide scientists to address the knowledge gaps currently associated with PDVs and promote new advances in plant-based therapeutic solutions. Nanyang Technological University Published version This work was supported by the National University of Singapore (Nano Nash Program A-0004336-00-00 & A-0008504-00-00), and Nanyang Technological University, Singapore (grant number 001487-00001). G.P. would also like to thank the Industry Alignment Fund—Pre-Positioning (IAF-PP) grant (A20G1a0046 and R-148-000-307-305/A-0004345-00-00). 2023-08-01T07:28:18Z 2023-08-01T07:28:18Z 2022 Journal Article Lian, M. Q., Chng, W. H., Liang, J., Yeo, H. Q., Lee, C. K., Belaid, M., Tollemeto, M., Wacker, M. G., Czarny, B. & Pastorin, G. (2022). Plant-derived extracellular vesicles: recent advancements and current challenges on their use for biomedical applications. Journal of Extracellular Vesicles, 11(12), e12283-. https://dx.doi.org/10.1002/jev2.12283 2001-3078 https://hdl.handle.net/10356/169739 10.1002/jev2.12283 36519808 2-s2.0-85144586980 12 11 e12283 en A-0004336-00-00 A-0008504-00-00 001487-00001 Journal of Extracellular Vesicles © 2022 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivsLicense, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. application/pdf |
| spellingShingle | Engineering::Materials Plant-Derived Extracellular Vesicles Plant-Derived Nanoparticles Lian, Meredith Qikai Chng, Wei Heng Liang, Jeremy Yeo, Hui Qing Lee, Choon Keong Belaid, Mona Tollemeto, Matteo Wacker, Matthias Gerhard Czarny, Bertrand Pastorin, Giorgia Plant-derived extracellular vesicles: recent advancements and current challenges on their use for biomedical applications |
| title | Plant-derived extracellular vesicles: recent advancements and current challenges on their use for biomedical applications |
| title_full | Plant-derived extracellular vesicles: recent advancements and current challenges on their use for biomedical applications |
| title_fullStr | Plant-derived extracellular vesicles: recent advancements and current challenges on their use for biomedical applications |
| title_full_unstemmed | Plant-derived extracellular vesicles: recent advancements and current challenges on their use for biomedical applications |
| title_short | Plant-derived extracellular vesicles: recent advancements and current challenges on their use for biomedical applications |
| title_sort | plant derived extracellular vesicles recent advancements and current challenges on their use for biomedical applications |
| topic | Engineering::Materials Plant-Derived Extracellular Vesicles Plant-Derived Nanoparticles |
| url | https://hdl.handle.net/10356/169739 |
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