Gut microbiome dysbiosis across early Parkinson's disease, REM sleep behavior disorder and their first-degree relatives
The microbiota-gut-brain axis has been suggested to play an important role in Parkinson's disease (PD). Here we performed a cross-sectional study to profile gut microbiota across early PD, REM sleep behavior disorder (RBD), first-degree relatives of RBD (RBD-FDR), and healthy controls, which co...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://hdl.handle.net/10356/169763 |
| _version_ | 1811688852635516928 |
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| author | Huang, Bei Chau, Steven W. H. Liu, Yaping Chan, Joey W. Y. Wang, Jing Ma, Suk Ling Zhang, Jihui Chan, Paul K. S. Yeoh, Yun Kit Chen, Zigui Zhou, Li Wong, Sunny Hei Mok, Vincent C. T. To, Ka Fai Lai, Hei Ming Ng, Simon Trenkwalder, Claudia Chan, Francis K. L. Wing, Yun Kwok |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Huang, Bei Chau, Steven W. H. Liu, Yaping Chan, Joey W. Y. Wang, Jing Ma, Suk Ling Zhang, Jihui Chan, Paul K. S. Yeoh, Yun Kit Chen, Zigui Zhou, Li Wong, Sunny Hei Mok, Vincent C. T. To, Ka Fai Lai, Hei Ming Ng, Simon Trenkwalder, Claudia Chan, Francis K. L. Wing, Yun Kwok |
| author_sort | Huang, Bei |
| collection | NTU |
| description | The microbiota-gut-brain axis has been suggested to play an important role in Parkinson's disease (PD). Here we performed a cross-sectional study to profile gut microbiota across early PD, REM sleep behavior disorder (RBD), first-degree relatives of RBD (RBD-FDR), and healthy controls, which could reflect the gut-brain staging model of PD. We show gut microbiota compositions are significantly altered in early PD and RBD compared with control and RBD-FDR. Depletion of butyrate-producing bacteria and enrichment of pro-inflammatory Collinsella have already emerged in RBD and RBD-FDR after controlling potential confounders including antidepressants, osmotic laxatives, and bowel movement frequency. Random forest modelling identifies 12 microbial markers that are effective to distinguish RBD from control. These findings suggest that PD-like gut dysbiosis occurs at the prodromal stages of PD when RBD develops and starts to emerge in the younger RBD-FDR subjects. The study will have etiological and diagnostic implications. |
| first_indexed | 2024-10-01T05:38:48Z |
| format | Journal Article |
| id | ntu-10356/169763 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:38:48Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1697632023-08-06T15:38:22Z Gut microbiome dysbiosis across early Parkinson's disease, REM sleep behavior disorder and their first-degree relatives Huang, Bei Chau, Steven W. H. Liu, Yaping Chan, Joey W. Y. Wang, Jing Ma, Suk Ling Zhang, Jihui Chan, Paul K. S. Yeoh, Yun Kit Chen, Zigui Zhou, Li Wong, Sunny Hei Mok, Vincent C. T. To, Ka Fai Lai, Hei Ming Ng, Simon Trenkwalder, Claudia Chan, Francis K. L. Wing, Yun Kwok Lee Kong Chian School of Medicine (LKCMedicine) Centre for Microbiome Medicine Science::Medicine Antidepressant Agent Anxiety Disorder The microbiota-gut-brain axis has been suggested to play an important role in Parkinson's disease (PD). Here we performed a cross-sectional study to profile gut microbiota across early PD, REM sleep behavior disorder (RBD), first-degree relatives of RBD (RBD-FDR), and healthy controls, which could reflect the gut-brain staging model of PD. We show gut microbiota compositions are significantly altered in early PD and RBD compared with control and RBD-FDR. Depletion of butyrate-producing bacteria and enrichment of pro-inflammatory Collinsella have already emerged in RBD and RBD-FDR after controlling potential confounders including antidepressants, osmotic laxatives, and bowel movement frequency. Random forest modelling identifies 12 microbial markers that are effective to distinguish RBD from control. These findings suggest that PD-like gut dysbiosis occurs at the prodromal stages of PD when RBD develops and starts to emerge in the younger RBD-FDR subjects. The study will have etiological and diagnostic implications. Published version This study was funded by the Health and Medical Research Fund of the Food and Health Bureau (Ref No.: 05162876 to Y.K.W.) and Research Grants Council (RGC-CRF Ref No.: C4044-21GF to Y.K.W.) of Hong Kong, China, and Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong (to Y.K.W. and S.H.W.). B.H. and J.W. were supported by the Faculty Postdoctoral Fellowship Scheme, Faculty of Medicine, CUHK. 2023-08-02T04:26:51Z 2023-08-02T04:26:51Z 2023 Journal Article Huang, B., Chau, S. W. H., Liu, Y., Chan, J. W. Y., Wang, J., Ma, S. L., Zhang, J., Chan, P. K. S., Yeoh, Y. K., Chen, Z., Zhou, L., Wong, S. H., Mok, V. C. T., To, K. F., Lai, H. M., Ng, S., Trenkwalder, C., Chan, F. K. L. & Wing, Y. K. (2023). Gut microbiome dysbiosis across early Parkinson's disease, REM sleep behavior disorder and their first-degree relatives. Nature Communications, 14(1), 2501-. https://dx.doi.org/10.1038/s41467-023-38248-4 2041-1723 https://hdl.handle.net/10356/169763 10.1038/s41467-023-38248-4 37130861 2-s2.0-85157963695 1 14 2501 en Nature Communications © The Author(s) 2023. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. application/pdf |
| spellingShingle | Science::Medicine Antidepressant Agent Anxiety Disorder Huang, Bei Chau, Steven W. H. Liu, Yaping Chan, Joey W. Y. Wang, Jing Ma, Suk Ling Zhang, Jihui Chan, Paul K. S. Yeoh, Yun Kit Chen, Zigui Zhou, Li Wong, Sunny Hei Mok, Vincent C. T. To, Ka Fai Lai, Hei Ming Ng, Simon Trenkwalder, Claudia Chan, Francis K. L. Wing, Yun Kwok Gut microbiome dysbiosis across early Parkinson's disease, REM sleep behavior disorder and their first-degree relatives |
| title | Gut microbiome dysbiosis across early Parkinson's disease, REM sleep behavior disorder and their first-degree relatives |
| title_full | Gut microbiome dysbiosis across early Parkinson's disease, REM sleep behavior disorder and their first-degree relatives |
| title_fullStr | Gut microbiome dysbiosis across early Parkinson's disease, REM sleep behavior disorder and their first-degree relatives |
| title_full_unstemmed | Gut microbiome dysbiosis across early Parkinson's disease, REM sleep behavior disorder and their first-degree relatives |
| title_short | Gut microbiome dysbiosis across early Parkinson's disease, REM sleep behavior disorder and their first-degree relatives |
| title_sort | gut microbiome dysbiosis across early parkinson s disease rem sleep behavior disorder and their first degree relatives |
| topic | Science::Medicine Antidepressant Agent Anxiety Disorder |
| url | https://hdl.handle.net/10356/169763 |
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