Molecular functions of the nuclear lamina in premature cell ageing
Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature ageing syndrome that manifests as early as 1 year of age. Patients exhibit severe phenotypes such as bone defects, cardiovascular complications, and a mean lifespan of 14 years. HGPS is caused by a silent heterozygous mutation that results i...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2023
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| Online Access: | https://hdl.handle.net/10356/169879 |