Global epidemiology and genetics of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the leading cancers worldwide. Classically, HCC develops in genetically susceptible individuals who are exposed to risk factors, especially in the presence of liver cirrhosis. Significant temporal and geographic variations exist for HCC and its etiologies. Ov...
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| Format: | Journal Article |
| Sprache: | English |
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2023
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| Online Zugang: | https://hdl.handle.net/10356/169926 |
| _version_ | 1826120360022507520 |
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| author | Toh, Ming Ren Wong, Evelyn Yi Ting Wong, Sunny Hei Ng, Alvin Wei Tian Loo, Lit-Hsin Chow, Pierce Kah-Hoe Ngeow, Joanne |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Toh, Ming Ren Wong, Evelyn Yi Ting Wong, Sunny Hei Ng, Alvin Wei Tian Loo, Lit-Hsin Chow, Pierce Kah-Hoe Ngeow, Joanne |
| author_sort | Toh, Ming Ren |
| collection | NTU |
| description | Hepatocellular carcinoma (HCC) is one of the leading cancers worldwide. Classically, HCC develops in genetically susceptible individuals who are exposed to risk factors, especially in the presence of liver cirrhosis. Significant temporal and geographic variations exist for HCC and its etiologies. Over time, the burden of HCC has shifted from the low-moderate to the high sociodemographic index regions, reflecting the transition from viral to nonviral causes. Geographically, the hepatitis viruses predominate as the causes of HCC in Asia and Africa. Although there are genetic conditions that confer increased risk for HCC, these diagnoses are rarely recognized outside North America and Europe. In this review, we will evaluate the epidemiologic trends and risk factors of HCC, and discuss the genetics of HCC, including monogenic diseases, single-nucleotide polymorphisms, gut microbiome, and somatic mutations. |
| first_indexed | 2024-10-01T05:14:56Z |
| format | Journal Article |
| id | ntu-10356/169926 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:14:56Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1699262023-08-15T03:56:53Z Global epidemiology and genetics of hepatocellular carcinoma Toh, Ming Ren Wong, Evelyn Yi Ting Wong, Sunny Hei Ng, Alvin Wei Tian Loo, Lit-Hsin Chow, Pierce Kah-Hoe Ngeow, Joanne Lee Kong Chian School of Medicine (LKCMedicine) National Cancer Centre Duke-NUS Medical School Science::Medicine Hepatocellular Carcinoma Epidemiology Hepatocellular carcinoma (HCC) is one of the leading cancers worldwide. Classically, HCC develops in genetically susceptible individuals who are exposed to risk factors, especially in the presence of liver cirrhosis. Significant temporal and geographic variations exist for HCC and its etiologies. Over time, the burden of HCC has shifted from the low-moderate to the high sociodemographic index regions, reflecting the transition from viral to nonviral causes. Geographically, the hepatitis viruses predominate as the causes of HCC in Asia and Africa. Although there are genetic conditions that confer increased risk for HCC, these diagnoses are rarely recognized outside North America and Europe. In this review, we will evaluate the epidemiologic trends and risk factors of HCC, and discuss the genetics of HCC, including monogenic diseases, single-nucleotide polymorphisms, gut microbiome, and somatic mutations. 2023-08-15T03:56:53Z 2023-08-15T03:56:53Z 2023 Journal Article Toh, M. R., Wong, E. Y. T., Wong, S. H., Ng, A. W. T., Loo, L., Chow, P. K. & Ngeow, J. (2023). Global epidemiology and genetics of hepatocellular carcinoma. Gastroenterology, 164(5), 766-782. https://dx.doi.org/10.1053/j.gastro.2023.01.033 0016-5085 https://hdl.handle.net/10356/169926 10.1053/j.gastro.2023.01.033 36738977 2-s2.0-85150243634 5 164 766 782 en Gastroenterology © 2023 the AGA Institute. All rights reserved. |
| spellingShingle | Science::Medicine Hepatocellular Carcinoma Epidemiology Toh, Ming Ren Wong, Evelyn Yi Ting Wong, Sunny Hei Ng, Alvin Wei Tian Loo, Lit-Hsin Chow, Pierce Kah-Hoe Ngeow, Joanne Global epidemiology and genetics of hepatocellular carcinoma |
| title | Global epidemiology and genetics of hepatocellular carcinoma |
| title_full | Global epidemiology and genetics of hepatocellular carcinoma |
| title_fullStr | Global epidemiology and genetics of hepatocellular carcinoma |
| title_full_unstemmed | Global epidemiology and genetics of hepatocellular carcinoma |
| title_short | Global epidemiology and genetics of hepatocellular carcinoma |
| title_sort | global epidemiology and genetics of hepatocellular carcinoma |
| topic | Science::Medicine Hepatocellular Carcinoma Epidemiology |
| url | https://hdl.handle.net/10356/169926 |
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