Risk factors for sessile serrated lesions among Chinese patients undergoing colonoscopy
Background and Aim: Serrated polyps have been recognized as a premalignant lesion accounting for a significant proportion of colorectal cancer. Limited data are available regarding the risk factors for colorectal sessile serrated lesions (SSLs). We aimed to investigate clinical risk factors of SSLs...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://hdl.handle.net/10356/169963 |
| _version_ | 1811687330433466368 |
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| author | Zhang, Ru Ni, Yunbi Guo, Cosmos L. T. Lui, Rashid N. S. Wu, William K. K. Sung, Joseph Jao Yiu Wong, Vincent W. S. Wong, Sunny Hei |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Zhang, Ru Ni, Yunbi Guo, Cosmos L. T. Lui, Rashid N. S. Wu, William K. K. Sung, Joseph Jao Yiu Wong, Vincent W. S. Wong, Sunny Hei |
| author_sort | Zhang, Ru |
| collection | NTU |
| description | Background and Aim: Serrated polyps have been recognized as a premalignant lesion accounting for a significant proportion of colorectal cancer. Limited data are available regarding the risk factors for colorectal sessile serrated lesions (SSLs). We aimed to investigate clinical risk factors of SSLs and compared them with colorectal adenomas in a study population of Chinese individuals. Methods: A retrospective case–control study was performed in an academic tertiary-referral center in Hong Kong. Subjects with SSLs and adenomas were identified from the hospital pathology database from January 2010 to December 2020, and additional clinical data were retrieved from the electronic patient record system. We compared clinical features and risk factors of SSL patients with those without these lesions. Results: A total of 2295 subjects were included in the study, including 459 subjects with SSLs, 918 subjects with adenomas, and 918 subjects with normal colonoscopy. By multi-variable logistic regression, compared with normal subjects, patients with SSLs only were significantly more likely to have dyslipidemia (adjusted OR: 1.431, 95% CI 1.008–2.030) and diabetes mellitus (adjusted OR: 2.119, 95% CI 1.439–3.122). Conclusions: Dyslipidemia and diabetes were independent risk factors for SSLs. Our findings suggest these metabolic factors may be important for the risk of SSLs. The findings may improve our understanding of SSLs and shed light on patient selection for screening and risk stratification. |
| first_indexed | 2024-10-01T05:14:36Z |
| format | Journal Article |
| id | ntu-10356/169963 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:14:36Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1699632023-08-20T15:37:32Z Risk factors for sessile serrated lesions among Chinese patients undergoing colonoscopy Zhang, Ru Ni, Yunbi Guo, Cosmos L. T. Lui, Rashid N. S. Wu, William K. K. Sung, Joseph Jao Yiu Wong, Vincent W. S. Wong, Sunny Hei Lee Kong Chian School of Medicine (LKCMedicine) Tan Tock Seng Hospital Science::Medicine Adenomas Risk Factors Background and Aim: Serrated polyps have been recognized as a premalignant lesion accounting for a significant proportion of colorectal cancer. Limited data are available regarding the risk factors for colorectal sessile serrated lesions (SSLs). We aimed to investigate clinical risk factors of SSLs and compared them with colorectal adenomas in a study population of Chinese individuals. Methods: A retrospective case–control study was performed in an academic tertiary-referral center in Hong Kong. Subjects with SSLs and adenomas were identified from the hospital pathology database from January 2010 to December 2020, and additional clinical data were retrieved from the electronic patient record system. We compared clinical features and risk factors of SSL patients with those without these lesions. Results: A total of 2295 subjects were included in the study, including 459 subjects with SSLs, 918 subjects with adenomas, and 918 subjects with normal colonoscopy. By multi-variable logistic regression, compared with normal subjects, patients with SSLs only were significantly more likely to have dyslipidemia (adjusted OR: 1.431, 95% CI 1.008–2.030) and diabetes mellitus (adjusted OR: 2.119, 95% CI 1.439–3.122). Conclusions: Dyslipidemia and diabetes were independent risk factors for SSLs. Our findings suggest these metabolic factors may be important for the risk of SSLs. The findings may improve our understanding of SSLs and shed light on patient selection for screening and risk stratification. Nanyang Technological University Published version This project was supported by National Natural Science Foundation of China Grant (81922082), the LKC School of Medicine Start Up Grant (021337-00001, 021281-00001), Centre for Microbiome Medicine and the Wang Lee Wah Memorial Fund. 2023-08-16T06:03:22Z 2023-08-16T06:03:22Z 2023 Journal Article Zhang, R., Ni, Y., Guo, C. L. T., Lui, R. N. S., Wu, W. K. K., Sung, J. J. Y., Wong, V. W. S. & Wong, S. H. (2023). Risk factors for sessile serrated lesions among Chinese patients undergoing colonoscopy. Journal of Gastroenterology and Hepatology, 1-6. https://dx.doi.org/10.1111/jgh.16200 0815-9319 https://hdl.handle.net/10356/169963 10.1111/jgh.16200 37128710 2-s2.0-85157998136 1 6 en 21337-00001 021281-00001 Journal of Gastroenterology and Hepatology © 2023 The Authors. Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. application/pdf |
| spellingShingle | Science::Medicine Adenomas Risk Factors Zhang, Ru Ni, Yunbi Guo, Cosmos L. T. Lui, Rashid N. S. Wu, William K. K. Sung, Joseph Jao Yiu Wong, Vincent W. S. Wong, Sunny Hei Risk factors for sessile serrated lesions among Chinese patients undergoing colonoscopy |
| title | Risk factors for sessile serrated lesions among Chinese patients undergoing colonoscopy |
| title_full | Risk factors for sessile serrated lesions among Chinese patients undergoing colonoscopy |
| title_fullStr | Risk factors for sessile serrated lesions among Chinese patients undergoing colonoscopy |
| title_full_unstemmed | Risk factors for sessile serrated lesions among Chinese patients undergoing colonoscopy |
| title_short | Risk factors for sessile serrated lesions among Chinese patients undergoing colonoscopy |
| title_sort | risk factors for sessile serrated lesions among chinese patients undergoing colonoscopy |
| topic | Science::Medicine Adenomas Risk Factors |
| url | https://hdl.handle.net/10356/169963 |
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