Impact of COVID-19 infection and vaccination in pancreatobiliary IgG4-related disease patients: an international multicenter study
Background and Aim: Dedicated studies evaluating the impact of COVID-19 on out-comes of pancreatobiliary IgG4 related disease (IgG4-RD) patients are scarce. WhetherCOVID-19 infection or vaccination would trigger IgG4-RD exacerbation remains unknown. Methods: Pancreatobiliary IgG4-RD patients≥18 year...
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| Format: | Journal Article |
| Language: | English |
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2023
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| Online Access: | https://hdl.handle.net/10356/170005 |
| _version_ | 1826113452487213056 |
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| author | Tang, Raymond S. Y. Sattayalertyanyong, Onuma Kuo, Yu-Ting Park, Kenneth H. Anastassiades, Constantinos Ligresti, Dario Hayashi, Nobuhiko Hasan, Aws Kim, Tae-Hyeon Pausawasdi, Nonthalee Wang, Hsiu-Po Lo, Simon K. Ho, Khek-Yu Barresi, Luca Traina, Mario Yasuda, Ichiro Savides, Thomas J. Koo, Chieh-Sian Chan, Ting Ting Lam, Thomas Y. T. Sung, Joseph Jao Yiu |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Tang, Raymond S. Y. Sattayalertyanyong, Onuma Kuo, Yu-Ting Park, Kenneth H. Anastassiades, Constantinos Ligresti, Dario Hayashi, Nobuhiko Hasan, Aws Kim, Tae-Hyeon Pausawasdi, Nonthalee Wang, Hsiu-Po Lo, Simon K. Ho, Khek-Yu Barresi, Luca Traina, Mario Yasuda, Ichiro Savides, Thomas J. Koo, Chieh-Sian Chan, Ting Ting Lam, Thomas Y. T. Sung, Joseph Jao Yiu |
| author_sort | Tang, Raymond S. Y. |
| collection | NTU |
| description | Background and Aim: Dedicated studies evaluating the impact of COVID-19 on out-comes of pancreatobiliary IgG4 related disease (IgG4-RD) patients are scarce. WhetherCOVID-19 infection or vaccination would trigger IgG4-RD exacerbation remains unknown. Methods: Pancreatobiliary IgG4-RD patients≥18 years old with active follow-up since January 2020 from nine referral centers in Asia, Europe, and North America were included in this multicenter retrospective study. Outcome measures include incidence and severity ofCOVID-19 infection, IgG4-RD disease activity and treatment status, interruption of indicated IgG4-RD treatment. Prospective data on COVID-19 vaccination status and newCOVID-19 infection during the Omicron outbreak were also retrieved in the Hong Kong cohort. Results: Of the 124 pancreatobiliary IgG4-RD patients, 25.0% had active IgG4-RD, 71.0%were on immunosuppressive therapies and 80.6% had≥1 risk factor for severe COVID. In2020 (pre-vaccination period), two patients (1.6%) had COVID-19 infection (one requiring ICU admission), and 7.2% of patients had interruptions in indicated immunosuppressive treatment for IgG4-RD. Despite a high vaccination rate (85.0%), COVID-19 infection rate has increased to 20.0% during Omicron outbreak in the Hong Kong cohort. A trend to-wards higher COVID-19 infection rate was noted in the non-fully vaccinated/unvaccinated group (17.6%vs33.3%, P= 0.376). No IgG4-RD exacerbation followingCOVID-19 vaccination or infection was observed. Conclusion: While a low COVID-19 infection rate with no mortality was observed in pancreatobiliary IgG4-RD patients in the pre-vaccination period of COVID-19, infection rate has increased during the Omicron outbreak despite a high vaccination rate. NoIgG4-RD exacerbation after COVID-19 infection or vaccination was observed. |
| first_indexed | 2024-10-01T03:23:49Z |
| format | Journal Article |
| id | ntu-10356/170005 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:23:49Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1700052023-08-21T05:15:44Z Impact of COVID-19 infection and vaccination in pancreatobiliary IgG4-related disease patients: an international multicenter study Tang, Raymond S. Y. Sattayalertyanyong, Onuma Kuo, Yu-Ting Park, Kenneth H. Anastassiades, Constantinos Ligresti, Dario Hayashi, Nobuhiko Hasan, Aws Kim, Tae-Hyeon Pausawasdi, Nonthalee Wang, Hsiu-Po Lo, Simon K. Ho, Khek-Yu Barresi, Luca Traina, Mario Yasuda, Ichiro Savides, Thomas J. Koo, Chieh-Sian Chan, Ting Ting Lam, Thomas Y. T. Sung, Joseph Jao Yiu Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine COVID-19 Vaccination Immunosuppressive Therapy Background and Aim: Dedicated studies evaluating the impact of COVID-19 on out-comes of pancreatobiliary IgG4 related disease (IgG4-RD) patients are scarce. WhetherCOVID-19 infection or vaccination would trigger IgG4-RD exacerbation remains unknown. Methods: Pancreatobiliary IgG4-RD patients≥18 years old with active follow-up since January 2020 from nine referral centers in Asia, Europe, and North America were included in this multicenter retrospective study. Outcome measures include incidence and severity ofCOVID-19 infection, IgG4-RD disease activity and treatment status, interruption of indicated IgG4-RD treatment. Prospective data on COVID-19 vaccination status and newCOVID-19 infection during the Omicron outbreak were also retrieved in the Hong Kong cohort. Results: Of the 124 pancreatobiliary IgG4-RD patients, 25.0% had active IgG4-RD, 71.0%were on immunosuppressive therapies and 80.6% had≥1 risk factor for severe COVID. In2020 (pre-vaccination period), two patients (1.6%) had COVID-19 infection (one requiring ICU admission), and 7.2% of patients had interruptions in indicated immunosuppressive treatment for IgG4-RD. Despite a high vaccination rate (85.0%), COVID-19 infection rate has increased to 20.0% during Omicron outbreak in the Hong Kong cohort. A trend to-wards higher COVID-19 infection rate was noted in the non-fully vaccinated/unvaccinated group (17.6%vs33.3%, P= 0.376). No IgG4-RD exacerbation followingCOVID-19 vaccination or infection was observed. Conclusion: While a low COVID-19 infection rate with no mortality was observed in pancreatobiliary IgG4-RD patients in the pre-vaccination period of COVID-19, infection rate has increased during the Omicron outbreak despite a high vaccination rate. NoIgG4-RD exacerbation after COVID-19 infection or vaccination was observed. 2023-08-21T05:15:43Z 2023-08-21T05:15:43Z 2023 Journal Article Tang, R. S. Y., Sattayalertyanyong, O., Kuo, Y., Park, K. H., Anastassiades, C., Ligresti, D., Hayashi, N., Hasan, A., Kim, T., Pausawasdi, N., Wang, H., Lo, S. K., Ho, K., Barresi, L., Traina, M., Yasuda, I., Savides, T. J., Koo, C., Chan, T. T., ...Sung, J. J. Y. (2023). Impact of COVID-19 infection and vaccination in pancreatobiliary IgG4-related disease patients: an international multicenter study. Journal of Gastroenterology and Hepatology, 38(4), 584-589. https://dx.doi.org/10.1111/jgh.16100 0815-9319 https://hdl.handle.net/10356/170005 10.1111/jgh.16100 36582040 2-s2.0-85146095831 4 38 584 589 en Journal of Gastroenterology and Hepatology © 2022 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. All rights reserved. |
| spellingShingle | Science::Medicine COVID-19 Vaccination Immunosuppressive Therapy Tang, Raymond S. Y. Sattayalertyanyong, Onuma Kuo, Yu-Ting Park, Kenneth H. Anastassiades, Constantinos Ligresti, Dario Hayashi, Nobuhiko Hasan, Aws Kim, Tae-Hyeon Pausawasdi, Nonthalee Wang, Hsiu-Po Lo, Simon K. Ho, Khek-Yu Barresi, Luca Traina, Mario Yasuda, Ichiro Savides, Thomas J. Koo, Chieh-Sian Chan, Ting Ting Lam, Thomas Y. T. Sung, Joseph Jao Yiu Impact of COVID-19 infection and vaccination in pancreatobiliary IgG4-related disease patients: an international multicenter study |
| title | Impact of COVID-19 infection and vaccination in pancreatobiliary IgG4-related disease patients: an international multicenter study |
| title_full | Impact of COVID-19 infection and vaccination in pancreatobiliary IgG4-related disease patients: an international multicenter study |
| title_fullStr | Impact of COVID-19 infection and vaccination in pancreatobiliary IgG4-related disease patients: an international multicenter study |
| title_full_unstemmed | Impact of COVID-19 infection and vaccination in pancreatobiliary IgG4-related disease patients: an international multicenter study |
| title_short | Impact of COVID-19 infection and vaccination in pancreatobiliary IgG4-related disease patients: an international multicenter study |
| title_sort | impact of covid 19 infection and vaccination in pancreatobiliary igg4 related disease patients an international multicenter study |
| topic | Science::Medicine COVID-19 Vaccination Immunosuppressive Therapy |
| url | https://hdl.handle.net/10356/170005 |
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