Cold sintering of bioglass and bioglass/polymer composites
Bioactive glasses are widely utilized to regenerate bone tissue and aid bonding of orthopedic implants. Forming composites of bioglass with bioactive polymers allow the mechanical properties and biological response to be tailored. Although several methods for creating bioglass–polymer composites exi...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/170122 |
| _version_ | 1811689051362689024 |
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| author | Andrews, Jessica Bullock, George Miller, Cheryl A. Booth, Jonathan Ren, Hong Kelly, Nichole L. Hanna, John V. Reaney, Ian M. |
| author2 | School of Materials Science and Engineering |
| author_facet | School of Materials Science and Engineering Andrews, Jessica Bullock, George Miller, Cheryl A. Booth, Jonathan Ren, Hong Kelly, Nichole L. Hanna, John V. Reaney, Ian M. |
| author_sort | Andrews, Jessica |
| collection | NTU |
| description | Bioactive glasses are widely utilized to regenerate bone tissue and aid bonding of orthopedic implants. Forming composites of bioglass with bioactive polymers allow the mechanical properties and biological response to be tailored. Although several methods for creating bioglass–polymer composites exist, they require dissolution of the polymer, controlled phase separation, and appear to have an upper limit of ∼30 vol.% bioglass. Cold sintering is a novel technique for the densification of ceramics and glasses which utilizes a liquid phase and pressure to allow the production of components at reduced temperatures. We demonstrate that cold sintering (100°C) of Bioglass 45S5 powder produced via flame spray pyrolysis and the fabrication of Bioglass 45S5–polymer composites. Assessment of the in vitro response revealed that composites were not cytotoxic. Solid-state 31P and 29Si MAS NMR studies of the silicon and phosphorus speciation in the glass powder, as-received, wetted, and sintered samples show similarities to reactions expected when bioglass is implanted in the body which along with Raman spectroscopy data gave insight into the cold sintering densification mechanism. |
| first_indexed | 2024-10-01T05:41:57Z |
| format | Journal Article |
| id | ntu-10356/170122 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:41:57Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1701222023-09-01T15:44:09Z Cold sintering of bioglass and bioglass/polymer composites Andrews, Jessica Bullock, George Miller, Cheryl A. Booth, Jonathan Ren, Hong Kelly, Nichole L. Hanna, John V. Reaney, Ian M. School of Materials Science and Engineering Engineering::Materials Low Temperature Biocompatibility Bioactive glasses are widely utilized to regenerate bone tissue and aid bonding of orthopedic implants. Forming composites of bioglass with bioactive polymers allow the mechanical properties and biological response to be tailored. Although several methods for creating bioglass–polymer composites exist, they require dissolution of the polymer, controlled phase separation, and appear to have an upper limit of ∼30 vol.% bioglass. Cold sintering is a novel technique for the densification of ceramics and glasses which utilizes a liquid phase and pressure to allow the production of components at reduced temperatures. We demonstrate that cold sintering (100°C) of Bioglass 45S5 powder produced via flame spray pyrolysis and the fabrication of Bioglass 45S5–polymer composites. Assessment of the in vitro response revealed that composites were not cytotoxic. Solid-state 31P and 29Si MAS NMR studies of the silicon and phosphorus speciation in the glass powder, as-received, wetted, and sintered samples show similarities to reactions expected when bioglass is implanted in the body which along with Raman spectroscopy data gave insight into the cold sintering densification mechanism. Published version JA thanks Johnson Matthey for PhD funding and support. NLK thanks EPSRC for a PhD studentship through the EPSRC Centre for Doctoral Training in Molecular Analytical Science (EP/L015307/1). JVH acknowledges financial support for the solid-state NMR instrumentation at Warwick used in this research which was funded by EPSRC (grants EP/M028186/1 and EP/K024418/1), the University of Warwick, and the Birmingham Science City AM1 and AM2 projects which were supported by Advantage West Midlands (AWM) and the European Regional Development Fund (ERDF). 2023-08-29T01:45:09Z 2023-08-29T01:45:09Z 2023 Journal Article Andrews, J., Bullock, G., Miller, C. A., Booth, J., Ren, H., Kelly, N. L., Hanna, J. V. & Reaney, I. M. (2023). Cold sintering of bioglass and bioglass/polymer composites. Journal of the American Ceramic Society, 106(6), 3396-3409. https://dx.doi.org/10.1111/jace.19022 0002-7820 https://hdl.handle.net/10356/170122 10.1111/jace.19022 2-s2.0-85148935611 6 106 3396 3409 en Journal of the American Ceramic Society © 2023 The Authors. Journal of the American Ceramic Society published by Wiley Periodicals LLC on behalf of American Ceramic Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. application/pdf |
| spellingShingle | Engineering::Materials Low Temperature Biocompatibility Andrews, Jessica Bullock, George Miller, Cheryl A. Booth, Jonathan Ren, Hong Kelly, Nichole L. Hanna, John V. Reaney, Ian M. Cold sintering of bioglass and bioglass/polymer composites |
| title | Cold sintering of bioglass and bioglass/polymer composites |
| title_full | Cold sintering of bioglass and bioglass/polymer composites |
| title_fullStr | Cold sintering of bioglass and bioglass/polymer composites |
| title_full_unstemmed | Cold sintering of bioglass and bioglass/polymer composites |
| title_short | Cold sintering of bioglass and bioglass/polymer composites |
| title_sort | cold sintering of bioglass and bioglass polymer composites |
| topic | Engineering::Materials Low Temperature Biocompatibility |
| url | https://hdl.handle.net/10356/170122 |
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