Mitochondrial dysfunction-targeted nanosystems for precise tumor therapeutics
Mitochondria play critical roles in the regulation of the proliferation and apoptosis of cancerous cells. Targeted induction of mitochondrial dysfunction in cancer cells by multifunctional nanosystems for cancer treatment has attracted increasing attention in the past few years. Numerous therapeutic...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://hdl.handle.net/10356/170343 |
| _version_ | 1826116817254350848 |
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| author | Ma, Zhaoyu Han, Heyou Zhao, Yanli |
| author2 | School of Chemistry, Chemical Engineering and Biotechnology |
| author_facet | School of Chemistry, Chemical Engineering and Biotechnology Ma, Zhaoyu Han, Heyou Zhao, Yanli |
| author_sort | Ma, Zhaoyu |
| collection | NTU |
| description | Mitochondria play critical roles in the regulation of the proliferation and apoptosis of cancerous cells. Targeted induction of mitochondrial dysfunction in cancer cells by multifunctional nanosystems for cancer treatment has attracted increasing attention in the past few years. Numerous therapeutic nanosystems have been designed for precise tumor therapy by inducing mitochondrial dysfunction, including reducing adenosine triphosphate, breaking redox homeostasis, inhibiting glycolysis, regulating proteins, membrane potential depolarization, mtDNA damage, mitophagy dysregulation and so on. Understanding the mechanisms of mitochondrial dysfunction would be helpful for efficient treatment of diseases and accelerating the translation of these therapeutic strategies into the clinic. Then, various strategies to construct mitochondria-targeted nanosystems and induce mitochondrial dysfunction are summarized, and the recent research progress regarding precise tumor therapeutics is highlighted. Finally, the major challenges and an outlook in this rapidly developing field are discussed. This review is expected to inspire further development of novel mitochondrial dysfunction-based strategies for precise treatments of cancer and other human diseases. |
| first_indexed | 2024-10-01T04:17:38Z |
| format | Journal Article |
| id | ntu-10356/170343 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:17:38Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1703432023-10-13T15:31:49Z Mitochondrial dysfunction-targeted nanosystems for precise tumor therapeutics Ma, Zhaoyu Han, Heyou Zhao, Yanli School of Chemistry, Chemical Engineering and Biotechnology Science::Chemistry Cancer Therapeutics Mitochondria Targeting Mitochondria play critical roles in the regulation of the proliferation and apoptosis of cancerous cells. Targeted induction of mitochondrial dysfunction in cancer cells by multifunctional nanosystems for cancer treatment has attracted increasing attention in the past few years. Numerous therapeutic nanosystems have been designed for precise tumor therapy by inducing mitochondrial dysfunction, including reducing adenosine triphosphate, breaking redox homeostasis, inhibiting glycolysis, regulating proteins, membrane potential depolarization, mtDNA damage, mitophagy dysregulation and so on. Understanding the mechanisms of mitochondrial dysfunction would be helpful for efficient treatment of diseases and accelerating the translation of these therapeutic strategies into the clinic. Then, various strategies to construct mitochondria-targeted nanosystems and induce mitochondrial dysfunction are summarized, and the recent research progress regarding precise tumor therapeutics is highlighted. Finally, the major challenges and an outlook in this rapidly developing field are discussed. This review is expected to inspire further development of novel mitochondrial dysfunction-based strategies for precise treatments of cancer and other human diseases. Agency for Science, Technology and Research (A*STAR) National Research Foundation (NRF) Submitted/Accepted version This work was supported by the China Scholarship Council (202006760059), and the National Natural Science Foundation of China (21778020). This work is also supported by the Singapore Agency for Science, Technology and Research (A*STAR) AME IRG Grant (A20E5c0081), and the Singapore National Research Foundation Investigatorship (NRF-NRFI2018-03). 2023-09-08T02:27:58Z 2023-09-08T02:27:58Z 2023 Journal Article Ma, Z., Han, H. & Zhao, Y. (2023). Mitochondrial dysfunction-targeted nanosystems for precise tumor therapeutics. Biomaterials, 293, 121947-. https://dx.doi.org/10.1016/j.biomaterials.2022.121947 0142-9612 https://hdl.handle.net/10356/170343 10.1016/j.biomaterials.2022.121947 36512861 2-s2.0-85143726655 293 121947 en A20E5c0081 NRF-NRFI2018-03 Biomaterials © 2022 Elsevier Ltd. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org/10.1016/j.biomaterials.2022.121947. application/pdf |
| spellingShingle | Science::Chemistry Cancer Therapeutics Mitochondria Targeting Ma, Zhaoyu Han, Heyou Zhao, Yanli Mitochondrial dysfunction-targeted nanosystems for precise tumor therapeutics |
| title | Mitochondrial dysfunction-targeted nanosystems for precise tumor therapeutics |
| title_full | Mitochondrial dysfunction-targeted nanosystems for precise tumor therapeutics |
| title_fullStr | Mitochondrial dysfunction-targeted nanosystems for precise tumor therapeutics |
| title_full_unstemmed | Mitochondrial dysfunction-targeted nanosystems for precise tumor therapeutics |
| title_short | Mitochondrial dysfunction-targeted nanosystems for precise tumor therapeutics |
| title_sort | mitochondrial dysfunction targeted nanosystems for precise tumor therapeutics |
| topic | Science::Chemistry Cancer Therapeutics Mitochondria Targeting |
| url | https://hdl.handle.net/10356/170343 |
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