Extended epiphenotypes: integrating epigenotypes into host behavioural manipulation by parasites
Biologists have long known that environmental context can create diverse phenotypes from identical genotypes. Thus, cells of the same foetus can grow into various organs depending on the molecular environment. Also, animals of the same genetic heritage can show different behaviours in different envi...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/170377 |
| _version_ | 1826117554162106368 |
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| author | Pavey, Chris Vyas, Ajai |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Pavey, Chris Vyas, Ajai |
| author_sort | Pavey, Chris |
| collection | NTU |
| description | Biologists have long known that environmental context can create diverse phenotypes from identical genotypes. Thus, cells of the same foetus can grow into various organs depending on the molecular environment. Also, animals of the same genetic heritage can show different behaviours in different environments. Conrad Hal Waddington conceptualized epigenotypes in the 1930s, whereby modifications of genetic material could generate alternative modules of development arising out of nonvariant genetic information. His concept paved the way for a neo-Darwinian synthesis by creating bidirectionality between the environment and genes. In a completely independent intellectual universe, Richard Dawkins introduced the idea of extended phenotype in the early 1980s. The hypothesis posits that the appropriate phenotype of genetic information is not limited to the organism but can ‘extend’ beyond the environment. Parasite manipulation of host behaviour presents a dramatic example of such extended phenotypes. In this perspective, we propose a synthesis between the earlier concept of epigenotypes and the later idea of extended phenotypes, namely a novel concept of extended epiphenotypes. |
| first_indexed | 2024-10-01T04:29:31Z |
| format | Journal Article |
| id | ntu-10356/170377 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:29:31Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1703772023-09-11T01:59:44Z Extended epiphenotypes: integrating epigenotypes into host behavioural manipulation by parasites Pavey, Chris Vyas, Ajai School of Biological Sciences Science::Biological sciences Behavioural Variation Conditional Behaviours Biologists have long known that environmental context can create diverse phenotypes from identical genotypes. Thus, cells of the same foetus can grow into various organs depending on the molecular environment. Also, animals of the same genetic heritage can show different behaviours in different environments. Conrad Hal Waddington conceptualized epigenotypes in the 1930s, whereby modifications of genetic material could generate alternative modules of development arising out of nonvariant genetic information. His concept paved the way for a neo-Darwinian synthesis by creating bidirectionality between the environment and genes. In a completely independent intellectual universe, Richard Dawkins introduced the idea of extended phenotype in the early 1980s. The hypothesis posits that the appropriate phenotype of genetic information is not limited to the organism but can ‘extend’ beyond the environment. Parasite manipulation of host behaviour presents a dramatic example of such extended phenotypes. In this perspective, we propose a synthesis between the earlier concept of epigenotypes and the later idea of extended phenotypes, namely a novel concept of extended epiphenotypes. This research was funded by Human Frontier Science Program, Grant Number: RGP0062/2018. 2023-09-11T01:59:44Z 2023-09-11T01:59:44Z 2023 Journal Article Pavey, C. & Vyas, A. (2023). Extended epiphenotypes: integrating epigenotypes into host behavioural manipulation by parasites. Functional Ecology, 37(4), 831-837. https://dx.doi.org/10.1111/1365-2435.14181 0269-8463 https://hdl.handle.net/10356/170377 10.1111/1365-2435.14181 2-s2.0-85139452282 4 37 831 837 en Functional Ecology © 2022 The Authors. All rights reserved. |
| spellingShingle | Science::Biological sciences Behavioural Variation Conditional Behaviours Pavey, Chris Vyas, Ajai Extended epiphenotypes: integrating epigenotypes into host behavioural manipulation by parasites |
| title | Extended epiphenotypes: integrating epigenotypes into host behavioural manipulation by parasites |
| title_full | Extended epiphenotypes: integrating epigenotypes into host behavioural manipulation by parasites |
| title_fullStr | Extended epiphenotypes: integrating epigenotypes into host behavioural manipulation by parasites |
| title_full_unstemmed | Extended epiphenotypes: integrating epigenotypes into host behavioural manipulation by parasites |
| title_short | Extended epiphenotypes: integrating epigenotypes into host behavioural manipulation by parasites |
| title_sort | extended epiphenotypes integrating epigenotypes into host behavioural manipulation by parasites |
| topic | Science::Biological sciences Behavioural Variation Conditional Behaviours |
| url | https://hdl.handle.net/10356/170377 |
| work_keys_str_mv | AT paveychris extendedepiphenotypesintegratingepigenotypesintohostbehaviouralmanipulationbyparasites AT vyasajai extendedepiphenotypesintegratingepigenotypesintohostbehaviouralmanipulationbyparasites |