Mo₂C‐derived polyoxometalate for NIR-II photoacoustic imaging‐guided chemodynamic/photothermal synergistic therapy
To overcome the current limitations of chemodynamic therapy (CDT), a Mo2C-derived polyoxometalate (POM) is readily synthesized as a new CDT agent. It permits synergistic chemodynamic and photothermal therapy operating in the second near-infrared (NIR-II) biological transparent window for deep tissue...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://hdl.handle.net/10356/170453 |
| _version_ | 1826113554405654528 |
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| author | Liu, Gongyuan Zhu, Jiawei Guo, Heng Sun, Aihui Chen, Peng Xi, Lei Huang, Wei Song, Xuejiao Dong, Xiaochen |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Liu, Gongyuan Zhu, Jiawei Guo, Heng Sun, Aihui Chen, Peng Xi, Lei Huang, Wei Song, Xuejiao Dong, Xiaochen |
| author_sort | Liu, Gongyuan |
| collection | NTU |
| description | To overcome the current limitations of chemodynamic therapy (CDT), a Mo2C-derived polyoxometalate (POM) is readily synthesized as a new CDT agent. It permits synergistic chemodynamic and photothermal therapy operating in the second near-infrared (NIR-II) biological transparent window for deep tissue penetration. POM aggregated in an acidic tumor micro-environment (TME) whereby enables specific tumor targeting. In addition to the strong ability to produce singlet oxygen (1O2) presumably via Russell mechanism, its excellent photothermal conversion enhances the CDT effect, offers additional tumor ablation modality, and permits NIR-II photoacoustic imaging. Benefitting from the reversible redox property of molybdenum, the theranostics based on POM can escape from the antioxidant defense system. Moreover, combining the specific responsiveness to TME and localized laser irradiation, side-effects shall be largely avoided. |
| first_indexed | 2024-10-01T03:25:07Z |
| format | Journal Article |
| id | ntu-10356/170453 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:25:07Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1704532023-09-12T06:44:19Z Mo₂C‐derived polyoxometalate for NIR-II photoacoustic imaging‐guided chemodynamic/photothermal synergistic therapy Liu, Gongyuan Zhu, Jiawei Guo, Heng Sun, Aihui Chen, Peng Xi, Lei Huang, Wei Song, Xuejiao Dong, Xiaochen School of Chemical and Biomedical Engineering Science::Chemistry Chemodynamische Therapie Photoakustische Bildgebung To overcome the current limitations of chemodynamic therapy (CDT), a Mo2C-derived polyoxometalate (POM) is readily synthesized as a new CDT agent. It permits synergistic chemodynamic and photothermal therapy operating in the second near-infrared (NIR-II) biological transparent window for deep tissue penetration. POM aggregated in an acidic tumor micro-environment (TME) whereby enables specific tumor targeting. In addition to the strong ability to produce singlet oxygen (1O2) presumably via Russell mechanism, its excellent photothermal conversion enhances the CDT effect, offers additional tumor ablation modality, and permits NIR-II photoacoustic imaging. Benefitting from the reversible redox property of molybdenum, the theranostics based on POM can escape from the antioxidant defense system. Moreover, combining the specific responsiveness to TME and localized laser irradiation, side-effects shall be largely avoided. The work was supported by the NNSF of China (61525402, 61775095, 51803091, 61935004), Jiangsu Provincial key research and development plan (BE2017741), Six talent peak innovation team in Jiangsu Province (TD-SWYY-009). 2023-09-12T06:44:19Z 2023-09-12T06:44:19Z 2019 Journal Article Liu, G., Zhu, J., Guo, H., Sun, A., Chen, P., Xi, L., Huang, W., Song, X. & Dong, X. (2019). Mo₂C‐derived polyoxometalate for NIR-II photoacoustic imaging‐guided chemodynamic/photothermal synergistic therapy. Angewandte Chemie, 131(51), 18814-18819. https://dx.doi.org/10.1002/ange.201910815 0044-8249 https://hdl.handle.net/10356/170453 10.1002/ange.201910815 51 131 18814 18819 en Angewandte Chemie © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved. |
| spellingShingle | Science::Chemistry Chemodynamische Therapie Photoakustische Bildgebung Liu, Gongyuan Zhu, Jiawei Guo, Heng Sun, Aihui Chen, Peng Xi, Lei Huang, Wei Song, Xuejiao Dong, Xiaochen Mo₂C‐derived polyoxometalate for NIR-II photoacoustic imaging‐guided chemodynamic/photothermal synergistic therapy |
| title | Mo₂C‐derived polyoxometalate for NIR-II photoacoustic imaging‐guided chemodynamic/photothermal synergistic therapy |
| title_full | Mo₂C‐derived polyoxometalate for NIR-II photoacoustic imaging‐guided chemodynamic/photothermal synergistic therapy |
| title_fullStr | Mo₂C‐derived polyoxometalate for NIR-II photoacoustic imaging‐guided chemodynamic/photothermal synergistic therapy |
| title_full_unstemmed | Mo₂C‐derived polyoxometalate for NIR-II photoacoustic imaging‐guided chemodynamic/photothermal synergistic therapy |
| title_short | Mo₂C‐derived polyoxometalate for NIR-II photoacoustic imaging‐guided chemodynamic/photothermal synergistic therapy |
| title_sort | mo₂c derived polyoxometalate for nir ii photoacoustic imaging guided chemodynamic photothermal synergistic therapy |
| topic | Science::Chemistry Chemodynamische Therapie Photoakustische Bildgebung |
| url | https://hdl.handle.net/10356/170453 |
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