Microbiology and the microbiome in bronchiectasis
The microbiology in bronchiectasis has been historically defined by culture-based analysis of the airway microbiome and to date has largely focused on the detection and eradication of specific bacterial pathogens. Although central to our current understanding of disease, microbial culture alone mask...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2023
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| Online Access: | https://hdl.handle.net/10356/170512 |
| _version_ | 1811687406890385408 |
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| author | Mac Aogáin, Micheál Chotirmall, Sanjay Haresh |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Mac Aogáin, Micheál Chotirmall, Sanjay Haresh |
| author_sort | Mac Aogáin, Micheál |
| collection | NTU |
| description | The microbiology in bronchiectasis has been historically defined by culture-based analysis of the airway microbiome and to date has largely focused on the detection and eradication of specific bacterial pathogens. Although central to our current understanding of disease, microbial culture alone masks the holistic complexity of the microbiome and does not account for potential microbial interactions that define specific clinical phenotypes such as frequent exacerbators. Advances in next-generation sequencing including their analytical technologies can further complement and build upon our current understanding of the microbiology and microbiome in bronchiectasis providing improved patient stratification with prognostic significance. |
| first_indexed | 2024-10-01T05:15:49Z |
| format | Journal Article |
| id | ntu-10356/170512 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:15:49Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | ntu-10356/1705122023-09-18T01:39:39Z Microbiology and the microbiome in bronchiectasis Mac Aogáin, Micheál Chotirmall, Sanjay Haresh Lee Kong Chian School of Medicine (LKCMedicine) Tan Tock Seng Hospital Science::Medicine Bronchiectasis Bacteriome The microbiology in bronchiectasis has been historically defined by culture-based analysis of the airway microbiome and to date has largely focused on the detection and eradication of specific bacterial pathogens. Although central to our current understanding of disease, microbial culture alone masks the holistic complexity of the microbiome and does not account for potential microbial interactions that define specific clinical phenotypes such as frequent exacerbators. Advances in next-generation sequencing including their analytical technologies can further complement and build upon our current understanding of the microbiology and microbiome in bronchiectasis providing improved patient stratification with prognostic significance. Ministry of Health (MOH) National Medical Research Council (NMRC) This research is funded by Singapore Ministry of Health’s National Medical Research Council under its Clinician-Scientist Individual Research Grant (MOH-000141) (S.H.C.) and Clinician Scientist Award (MOH-000710) (S.H.C.). S.H.C is on advisory boards for CSL Behring and Boehringer Ingelheim and has received personal fees from AZ, all outside of the submitted work. M.M.A. 2023-09-18T01:39:39Z 2023-09-18T01:39:39Z 2022 Journal Article Mac Aogáin, M. & Chotirmall, S. H. (2022). Microbiology and the microbiome in bronchiectasis. Clinics in Chest Medicine, 43(1), 23-34. https://dx.doi.org/10.1016/j.ccm.2021.11.002 0272-5231 https://hdl.handle.net/10356/170512 10.1016/j.ccm.2021.11.002 35236558 2-s2.0-85125246174 1 43 23 34 en MOH-000141 MOH-000710 Clinics in Chest Medicine © 2023. Elsevier Inc. All rights reserved. |
| spellingShingle | Science::Medicine Bronchiectasis Bacteriome Mac Aogáin, Micheál Chotirmall, Sanjay Haresh Microbiology and the microbiome in bronchiectasis |
| title | Microbiology and the microbiome in bronchiectasis |
| title_full | Microbiology and the microbiome in bronchiectasis |
| title_fullStr | Microbiology and the microbiome in bronchiectasis |
| title_full_unstemmed | Microbiology and the microbiome in bronchiectasis |
| title_short | Microbiology and the microbiome in bronchiectasis |
| title_sort | microbiology and the microbiome in bronchiectasis |
| topic | Science::Medicine Bronchiectasis Bacteriome |
| url | https://hdl.handle.net/10356/170512 |
| work_keys_str_mv | AT macaogainmicheal microbiologyandthemicrobiomeinbronchiectasis AT chotirmallsanjayharesh microbiologyandthemicrobiomeinbronchiectasis |